ENSG00000167965

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397124 ENSG00000167965 HEK293_OSMI2_2hA HEK293_TMG_2hB MLST8 protein_coding protein_coding 144.0653 275.9738 86.0285 14.77009 1.920917 -1.681529 33.50794 64.22248 16.26890 6.3340085 0.32318377 -1.9802994 0.2169458 0.23296667 0.1892333 -0.04373333 3.319071e-01 2.294846e-19 FALSE TRUE
ENST00000565330 ENSG00000167965 HEK293_OSMI2_2hA HEK293_TMG_2hB MLST8 protein_coding retained_intron 144.0653 275.9738 86.0285 14.77009 1.920917 -1.681529 14.75129 22.16697 11.45194 0.5798319 0.05958254 -0.9522105 0.1149167 0.08056667 0.1332000 0.05263333 4.489822e-10 2.294846e-19 FALSE TRUE
ENST00000569417 ENSG00000167965 HEK293_OSMI2_2hA HEK293_TMG_2hB MLST8 protein_coding protein_coding 144.0653 275.9738 86.0285 14.77009 1.920917 -1.681529 61.84637 134.29610 31.34790 10.0417281 2.30572334 -2.0986238 0.4077542 0.48726667 0.3643000 -0.12296667 7.522246e-02 2.294846e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167965 E001 0.0000000       16 2204248 2204364 117 +      
ENSG00000167965 E002 0.0000000       16 2204589 2204595 7 +      
ENSG00000167965 E003 0.0000000       16 2204596 2204646 51 +      
ENSG00000167965 E004 0.0000000       16 2204647 2204682 36 +      
ENSG00000167965 E005 0.0000000       16 2204683 2204740 58 +      
ENSG00000167965 E006 0.0000000       16 2204741 2204858 118 +      
ENSG00000167965 E007 0.0000000       16 2204859 2204905 47 +      
ENSG00000167965 E008 0.0000000       16 2205153 2205176 24 +      
ENSG00000167965 E009 0.9921577 1.268836e-02 5.111878e-01 6.462878e-01 16 2205177 2205203 27 + 0.343 0.231 -0.778
ENSG00000167965 E010 2.2442814 6.800771e-02 9.789152e-01 9.908559e-01 16 2205204 2205224 21 + 0.448 0.463 0.074
ENSG00000167965 E011 4.7455074 8.089742e-02 4.319497e-01 5.744421e-01 16 2205225 2205256 32 + 0.532 0.722 0.827
ENSG00000167965 E012 9.7963506 9.359626e-02 9.952218e-01 1.000000e+00 16 2205257 2205419 163 + 0.916 0.959 0.165
ENSG00000167965 E013 30.0466526 8.726362e-04 4.889839e-01 6.264813e-01 16 2205420 2205449 30 + 1.320 1.400 0.277
ENSG00000167965 E014 35.8045105 9.489528e-03 1.611674e-01 2.766241e-01 16 2205450 2205453 4 + 1.332 1.485 0.528
ENSG00000167965 E015 36.8020659 1.091443e-02 1.735116e-01 2.927598e-01 16 2205454 2205455 2 + 1.344 1.496 0.525
ENSG00000167965 E016 39.4924574 6.767738e-03 5.964422e-02 1.260154e-01 16 2205456 2205456 1 + 1.344 1.530 0.640
ENSG00000167965 E017 54.5092689 4.989375e-03 2.544173e-01 3.910986e-01 16 2205457 2205464 8 + 1.548 1.655 0.364
ENSG00000167965 E018 147.4370531 2.204408e-03 1.055214e-01 1.989027e-01 16 2205465 2205470 6 + 2.097 2.056 -0.137
ENSG00000167965 E019 190.4054235 2.960707e-03 2.805404e-01 4.203946e-01 16 2205471 2205476 6 + 2.189 2.173 -0.055
ENSG00000167965 E020 218.1769452 1.325873e-03 1.767751e-01 2.970456e-01 16 2205477 2205480 4 + 2.249 2.230 -0.064
ENSG00000167965 E021 239.0781662 1.984410e-03 1.110882e-01 2.071390e-01 16 2205481 2205483 3 + 2.297 2.268 -0.095
ENSG00000167965 E022 272.3055361 7.333831e-04 1.423021e-02 3.875160e-02 16 2205484 2205486 3 + 2.365 2.321 -0.148
ENSG00000167965 E023 327.2196112 1.468249e-03 5.546800e-02 1.187896e-01 16 2205487 2205489 3 + 2.434 2.404 -0.099
ENSG00000167965 E024 334.2215341 1.637316e-03 3.985969e-02 9.077224e-02 16 2205490 2205493 4 + 2.447 2.413 -0.115
ENSG00000167965 E025 395.8968428 1.422497e-03 5.948223e-02 1.257406e-01 16 2205494 2205512 19 + 2.513 2.488 -0.083
ENSG00000167965 E026 26.8406600 6.825080e-03 1.920150e-03 6.977933e-03 16 2205513 2205730 218 + 1.518 1.287 -0.798
ENSG00000167965 E027 7.9763992 1.057215e-02 2.595429e-02 6.385466e-02 16 2205731 2205740 10 + 1.051 0.787 -0.999
ENSG00000167965 E028 53.9040673 1.933320e-02 8.756631e-01 9.241480e-01 16 2205741 2205768 28 + 1.623 1.642 0.064
ENSG00000167965 E029 265.9552155 4.663193e-03 4.191238e-01 5.623760e-01 16 2205769 2205875 107 + 2.271 2.336 0.217
ENSG00000167965 E030 96.8189434 2.766012e-04 7.796773e-01 8.583682e-01 16 2205876 2206028 153 + 1.876 1.888 0.042
ENSG00000167965 E031 52.8318881 6.104162e-04 6.883436e-01 7.905035e-01 16 2206029 2206030 2 + 1.629 1.630 0.003
ENSG00000167965 E032 658.9108458 1.460548e-03 2.308583e-01 3.635075e-01 16 2206031 2206060 30 + 2.717 2.716 -0.004
ENSG00000167965 E033 1294.8899395 1.162728e-03 4.093945e-01 5.530022e-01 16 2206061 2206214 154 + 2.998 3.012 0.044
ENSG00000167965 E034 474.5920596 1.291219e-03 2.366314e-01 3.702773e-01 16 2206358 2206360 3 + 2.575 2.572 -0.010
ENSG00000167965 E035 520.9078378 1.192331e-03 2.221627e-01 3.529936e-01 16 2206361 2206364 4 + 2.615 2.612 -0.008
ENSG00000167965 E036 856.3423731 8.850764e-04 2.778895e-01 4.175219e-01 16 2206365 2206409 45 + 2.824 2.830 0.021
ENSG00000167965 E037 104.5618721 2.713460e-04 1.754425e-08 2.068010e-07 16 2206410 2206478 69 + 2.069 1.872 -0.662
ENSG00000167965 E038 75.4510623 4.952891e-04 3.896840e-08 4.294617e-07 16 2206479 2206483 5 + 1.949 1.721 -0.771
ENSG00000167965 E039 108.3745712 2.919460e-04 5.332254e-09 6.922357e-08 16 2206484 2206496 13 + 2.087 1.885 -0.676
ENSG00000167965 E040 775.1813682 3.194172e-04 3.542447e-03 1.184695e-02 16 2206497 2206517 21 + 2.804 2.779 -0.081
ENSG00000167965 E041 929.1448280 7.919239e-05 1.386578e-02 3.792217e-02 16 2206518 2206554 37 + 2.871 2.861 -0.034
ENSG00000167965 E042 1477.3978989 1.021628e-04 4.392731e-03 1.424446e-02 16 2206555 2206659 105 + 3.070 3.062 -0.025
ENSG00000167965 E043 9.1992487 1.876430e-03 4.105887e-01 5.541885e-01 16 2206660 2206742 83 + 0.975 0.895 -0.299
ENSG00000167965 E044 26.6307463 3.289067e-03 1.757400e-07 1.703162e-06 16 2206743 2206929 187 + 1.604 1.236 -1.273
ENSG00000167965 E045 1208.2294729 1.169305e-03 7.054518e-01 8.038212e-01 16 2207035 2207110 76 + 2.962 2.983 0.071
ENSG00000167965 E046 113.7857754 2.805613e-04 4.692457e-02 1.036883e-01 16 2207111 2207192 82 + 1.999 1.945 -0.183
ENSG00000167965 E047 613.8912766 1.799197e-04 8.157274e-01 8.833771e-01 16 2207193 2207196 4 + 2.665 2.687 0.071
ENSG00000167965 E048 1745.6504599 1.495497e-04 3.926443e-01 5.365742e-01 16 2207197 2207345 149 + 3.124 3.141 0.056
ENSG00000167965 E049 12.6368564 1.612704e-03 2.089002e-04 1.002013e-03 16 2207346 2207547 202 + 1.294 0.950 -1.240
ENSG00000167965 E050 9.6256915 1.822322e-03 1.213695e-07 1.213420e-06 16 2207586 2207826 241 + 1.307 0.772 -1.971
ENSG00000167965 E051 2.9681568 5.234064e-02 5.929363e-03 1.842291e-02 16 2207827 2207856 30 + 0.846 0.383 -2.088
ENSG00000167965 E052 17.5867986 3.351559e-03 1.296401e-08 1.565224e-07 16 2207857 2208024 168 + 1.493 1.022 -1.662
ENSG00000167965 E053 11.5067530 1.536661e-03 2.897837e-08 3.271281e-07 16 2208025 2208209 185 + 1.367 0.844 -1.900
ENSG00000167965 E054 1725.7966291 1.361776e-04 9.534202e-01 9.748636e-01 16 2208210 2208334 125 + 3.111 3.138 0.090
ENSG00000167965 E055 23.4877897 1.394742e-03 1.555408e-02 4.174528e-02 16 2208335 2208449 115 + 1.420 1.248 -0.599
ENSG00000167965 E056 2192.9588416 1.245565e-03 1.156481e-01 2.137616e-01 16 2208450 2208613 164 + 3.192 3.250 0.192
ENSG00000167965 E057 40.2787075 9.797486e-04 1.012130e-01 1.923296e-01 16 2208614 2208758 145 + 1.400 1.543 0.492
ENSG00000167965 E058 3466.5303099 4.614366e-03 4.061348e-06 2.949174e-05 16 2208759 2209453 695 + 3.298 3.466 0.558