ENSG00000167962

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000561787 ENSG00000167962 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF598 protein_coding retained_intron 70.17621 100.6302 49.15523 8.19966 1.086096 -1.033497 11.628852 15.541789 8.717925 2.8650339 0.8409396 -0.8333699 0.16562500 0.15166667 0.17690000 0.025233333 6.861655e-01 1.33576e-12 FALSE FALSE
ENST00000562103 ENSG00000167962 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF598 protein_coding protein_coding 70.17621 100.6302 49.15523 8.19966 1.086096 -1.033497 20.190063 16.021076 25.866423 4.8760103 1.1445577 0.6907669 0.30585833 0.15320000 0.52570000 0.372500000 7.799346e-05 1.33576e-12 FALSE TRUE
ENST00000562988 ENSG00000167962 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF598 protein_coding retained_intron 70.17621 100.6302 49.15523 8.19966 1.086096 -1.033497 5.190766 6.943059 3.920536 0.7877154 0.4585847 -0.8229217 0.07593750 0.07123333 0.08020000 0.008966667 8.528524e-01 1.33576e-12 FALSE TRUE
ENST00000567008 ENSG00000167962 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF598 protein_coding retained_intron 70.17621 100.6302 49.15523 8.19966 1.086096 -1.033497 6.690768 12.548056 3.687129 0.1832969 0.5783947 -1.7641359 0.09210833 0.12680000 0.07520000 -0.051600000 1.238780e-01 1.33576e-12 FALSE FALSE
ENST00000652647 ENSG00000167962 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF598 protein_coding processed_transcript 70.17621 100.6302 49.15523 8.19966 1.086096 -1.033497 21.596879 42.630290 2.966213 1.6862820 0.5179158 -3.8406675 0.28929167 0.42963333 0.06066667 -0.368966667 1.794671e-12 1.33576e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167962 E001 1.399472 0.0096765512 2.683353e-02 6.564731e-02 16 1997654 1997654 1 - 0.001 0.445 10.488
ENSG00000167962 E002 1144.638655 0.0028843136 2.649216e-04 1.236843e-03 16 1997655 1998152 498 - 2.930 3.040 0.366
ENSG00000167962 E003 1161.490602 0.0006116505 8.661562e-11 1.545547e-09 16 1998153 1998423 271 - 2.932 3.046 0.376
ENSG00000167962 E004 481.368308 0.0001211765 1.491386e-03 5.608486e-03 16 1998424 1998479 56 - 2.585 2.650 0.218
ENSG00000167962 E005 397.231452 0.0001529856 8.012165e-02 1.597416e-01 16 1998480 1998502 23 - 2.519 2.561 0.142
ENSG00000167962 E006 336.365130 0.0007320265 4.579381e-02 1.016561e-01 16 1998503 1998521 19 - 2.435 2.493 0.194
ENSG00000167962 E007 520.879826 0.0005468567 1.320218e-01 2.369241e-01 16 1998522 1998585 64 - 2.641 2.679 0.128
ENSG00000167962 E008 71.988422 0.0012563785 1.625120e-05 1.028853e-04 16 1998586 1998701 116 - 1.944 1.755 -0.637
ENSG00000167962 E009 598.843396 0.0006442890 2.535150e-01 3.900438e-01 16 1998702 1998852 151 - 2.707 2.738 0.104
ENSG00000167962 E010 7.311780 0.0372839302 4.671772e-04 2.034418e-03 16 1998853 1998964 112 - 1.155 0.666 -1.871
ENSG00000167962 E011 369.076679 0.0001571579 1.599870e-05 1.014631e-04 16 1998965 1999121 157 - 2.443 2.543 0.331
ENSG00000167962 E012 9.741752 0.0504759871 1.718415e-02 4.534987e-02 16 1999122 1999195 74 - 1.196 0.854 -1.258
ENSG00000167962 E013 129.342596 0.0009995197 1.646333e-03 6.108719e-03 16 1999496 1999499 4 - 1.966 2.095 0.433
ENSG00000167962 E014 705.264254 0.0002590537 1.620365e-03 6.026293e-03 16 1999500 1999893 394 - 2.753 2.813 0.198
ENSG00000167962 E015 460.304016 0.0026344760 6.642792e-01 7.721211e-01 16 1999894 2000009 116 - 2.595 2.621 0.088
ENSG00000167962 E016 767.453290 0.0002376585 9.713149e-01 9.860869e-01 16 2000010 2000256 247 - 2.828 2.836 0.026
ENSG00000167962 E017 18.618568 0.0174356134 1.208997e-09 1.763751e-08 16 2000257 2000390 134 - 1.586 0.986 -2.112
ENSG00000167962 E018 181.856668 0.0002415753 4.205959e-01 5.637994e-01 16 2000391 2000408 18 - 2.225 2.209 -0.054
ENSG00000167962 E019 407.875446 0.0007329805 9.999796e-01 1.000000e+00 16 2000409 2000481 73 - 2.557 2.565 0.028
ENSG00000167962 E020 686.811009 0.0004124709 9.753708e-01 9.886449e-01 16 2001004 2001191 188 - 2.781 2.789 0.026
ENSG00000167962 E021 237.957658 0.0021198591 1.397547e-01 2.476880e-01 16 2001583 2001591 9 - 2.355 2.316 -0.130
ENSG00000167962 E022 565.841325 0.0019604817 1.609076e-01 2.763061e-01 16 2001592 2001700 109 - 2.723 2.697 -0.087
ENSG00000167962 E023 31.696305 0.0024904954 3.885588e-11 7.346030e-10 16 2001701 2001744 44 - 1.722 1.297 -1.460
ENSG00000167962 E024 727.568192 0.0006660471 6.025568e-07 5.246465e-06 16 2002206 2002423 218 - 2.868 2.788 -0.267
ENSG00000167962 E025 28.924394 0.0007098573 7.393740e-05 3.990175e-04 16 2002424 2002520 97 - 1.596 1.342 -0.872
ENSG00000167962 E026 607.364377 0.0001285863 6.997125e-24 6.859832e-22 16 2002521 2002732 212 - 2.834 2.686 -0.494
ENSG00000167962 E027 20.237963 0.0009153579 1.390375e-17 6.700645e-16 16 2002733 2002990 258 - 1.631 0.987 -2.261
ENSG00000167962 E028 315.128297 0.0001891100 3.246672e-07 2.982603e-06 16 2002991 2003116 126 - 2.521 2.417 -0.346
ENSG00000167962 E029 122.782803 0.0002594760 1.512685e-02 4.077482e-02 16 2003117 2003120 4 - 2.095 2.018 -0.257
ENSG00000167962 E030 16.316355 0.0025747560 4.544066e-14 1.355898e-12 16 2003121 2003615 495 - 1.540 0.899 -2.281
ENSG00000167962 E031 253.323573 0.0002097659 5.349547e-03 1.688248e-02 16 2003616 2003728 113 - 2.396 2.335 -0.203
ENSG00000167962 E032 173.949240 0.0038436699 1.687587e-04 8.298721e-04 16 2009524 2009821 298 - 2.290 2.147 -0.477