ENSG00000167904

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000434581 ENSG00000167904 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM68 protein_coding protein_coding 11.84462 3.401034 19.70525 0.463081 0.5334718 2.531031 5.2379608 1.8229384 8.4000878 0.316225713 0.20612053 2.197963 0.43077917 0.5313 0.42703333 -0.10426667 0.14681491 0.01849172 FALSE TRUE
ENST00000519780 ENSG00000167904 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM68 protein_coding protein_coding 11.84462 3.401034 19.70525 0.463081 0.5334718 2.531031 0.6230385 0.0000000 1.0913650 0.000000000 0.42275830 6.783149 0.03254167 0.0000 0.05460000 0.05460000 0.01849172 0.01849172 FALSE FALSE
ENST00000521229 ENSG00000167904 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM68 protein_coding protein_coding 11.84462 3.401034 19.70525 0.463081 0.5334718 2.531031 0.3661705 0.1773165 0.4470644 0.003179663 0.06613382 1.286919 0.05010417 0.0541 0.02273333 -0.03136667 0.13291425 0.01849172 FALSE TRUE
ENST00000522090 ENSG00000167904 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM68 protein_coding protein_coding 11.84462 3.401034 19.70525 0.463081 0.5334718 2.531031 0.7973798 0.0000000 1.0047980 0.000000000 1.00479797 6.665049 0.04578750 0.0000 0.05303333 0.05303333 1.00000000 0.01849172 FALSE FALSE
ENST00000522576 ENSG00000167904 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM68 protein_coding protein_coding 11.84462 3.401034 19.70525 0.463081 0.5334718 2.531031 2.6246682 1.1766561 3.8687553 0.264556921 0.66792718 1.708692 0.28830833 0.3454 0.19490000 -0.15050000 0.16357210 0.01849172 FALSE TRUE
MSTRG.31516.7 ENSG00000167904 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM68 protein_coding   11.84462 3.401034 19.70525 0.463081 0.5334718 2.531031 0.6278474 0.0000000 1.5842595 0.000000000 0.81473102 7.316743 0.03090833 0.0000 0.07860000 0.07860000 0.40817716 0.01849172 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167904 E001 0.5212538 0.0199547240 5.303347e-02 1.145418e-01 8 55696424 55696834 411 - 0.059 0.392 3.337
ENSG00000167904 E002 0.1451727 0.0434507916 1.000000e+00   8 55725116 55725259 144 - 0.059 0.000 -9.781
ENSG00000167904 E003 0.1482932 0.0411597534 7.766382e-02   8 55738744 55738757 14 - 0.000 0.238 12.369
ENSG00000167904 E004 85.6845959 0.0027626929 9.809679e-13 2.412272e-11 8 55738758 55739700 943 - 1.755 2.090 1.127
ENSG00000167904 E005 45.3119698 0.0004876530 1.034109e-04 5.378417e-04 8 55739701 55739790 90 - 1.515 1.747 0.791
ENSG00000167904 E006 38.0039381 0.0005781290 1.170185e-06 9.579052e-06 8 55739791 55739943 153 - 1.416 1.724 1.052
ENSG00000167904 E007 56.3422202 0.0032870706 4.816214e-01 6.198193e-01 8 55739944 55740171 228 - 1.666 1.623 -0.145
ENSG00000167904 E008 49.1745508 0.0006400981 1.964571e-01 3.217925e-01 8 55740172 55740218 47 - 1.612 1.531 -0.279
ENSG00000167904 E009 70.8735289 0.0005499310 7.091282e-03 2.146590e-02 8 55743481 55743620 140 - 1.780 1.630 -0.506
ENSG00000167904 E010 35.1027699 0.0030838073 3.954444e-02 9.018605e-02 8 55745061 55745077 17 - 1.487 1.317 -0.589
ENSG00000167904 E011 37.5882479 0.0071155846 5.905724e-02 1.250189e-01 8 55745078 55745091 14 - 1.513 1.347 -0.574
ENSG00000167904 E012 39.8444558 0.0047603678 2.264329e-03 8.043846e-03 8 55745092 55745121 30 - 1.550 1.285 -0.914
ENSG00000167904 E013 3.9599573 0.0040326796 4.685791e-01 6.079907e-01 8 55745122 55746047 926 - 0.636 0.504 -0.601
ENSG00000167904 E014 0.5827671 0.1619809665 6.265601e-01 7.425010e-01 8 55750887 55750963 77 - 0.198 0.000 -11.394
ENSG00000167904 E015 55.2104542 0.0006442473 2.351639e-03 8.312858e-03 8 55750964 55751050 87 - 1.679 1.481 -0.676
ENSG00000167904 E016 49.9198449 0.0004801470 8.339071e-04 3.380072e-03 8 55751051 55751157 107 - 1.643 1.413 -0.790
ENSG00000167904 E017 0.0000000       8 55751421 55751546 126 -      
ENSG00000167904 E018 23.3101525 0.0126411615 1.158405e-01 2.140098e-01 8 55756244 55756244 1 - 1.319 1.150 -0.596
ENSG00000167904 E019 45.9410469 0.0027343755 1.705872e-03 6.300883e-03 8 55756245 55756357 113 - 1.611 1.374 -0.813
ENSG00000167904 E020 33.3623957 0.0007238072 3.969810e-03 1.305771e-02 8 55756358 55756411 54 - 1.476 1.233 -0.847
ENSG00000167904 E021 11.1135889 0.0016771806 3.726896e-04 1.668201e-03 8 55760773 55762399 1627 - 0.884 1.269 1.399
ENSG00000167904 E022 21.8094573 0.0010023115 9.380721e-07 7.829542e-06 8 55762400 55762634 235 - 1.156 1.549 1.368
ENSG00000167904 E023 138.5081159 0.0002710530 2.953310e-01 4.364684e-01 8 55762635 55762953 319 - 2.036 2.077 0.138
ENSG00000167904 E024 70.0471956 0.0005522170 7.640164e-01 8.471905e-01 8 55762954 55763028 75 - 1.754 1.741 -0.042
ENSG00000167904 E025 1.7767927 0.0077478764 4.080603e-01 5.516523e-01 8 55763422 55763636 215 - 0.414 0.238 -1.123
ENSG00000167904 E026 1.3391983 0.0096765512 6.530068e-01 7.636006e-01 8 55763637 55763701 65 - 0.334 0.238 -0.664
ENSG00000167904 E027 57.6979949 0.0005081002 9.625634e-01 9.803764e-01 8 55763936 55763980 45 - 1.667 1.673 0.020
ENSG00000167904 E028 0.5933762 0.0224058994 5.736804e-01 6.996036e-01 8 55772976 55773226 251 - 0.198 0.000 -11.772
ENSG00000167904 E029 5.5915893 0.0051982219 9.422681e-01 9.677379e-01 8 55773227 55773268 42 - 0.739 0.731 -0.033
ENSG00000167904 E030 51.8449139 0.0031560033 4.382095e-02 9.805985e-02 8 55773269 55773407 139 - 1.649 1.511 -0.472