ENSG00000167889

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301618 ENSG00000167889 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5B protein_coding protein_coding 1.685521 2.688053 1.492082 0.0417018 0.1019593 -0.844955 0.32640597 0.2119184 0.6287520 0.21191841 0.10932901 1.5252266 0.21465000 0.07956667 0.4189333 0.33936667 8.532332e-02 1.133452e-06 FALSE TRUE
ENST00000374998 ENSG00000167889 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5B protein_coding processed_transcript 1.685521 2.688053 1.492082 0.0417018 0.1019593 -0.844955 0.08455708 0.1650095 0.0000000 0.02722957 0.00000000 -4.1293612 0.03584167 0.06166667 0.0000000 -0.06166667 4.976498e-03 1.133452e-06 FALSE TRUE
ENST00000428789 ENSG00000167889 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5B protein_coding protein_coding 1.685521 2.688053 1.492082 0.0417018 0.1019593 -0.844955 0.29876033 0.7571754 0.0000000 0.18740388 0.00000000 -6.2614846 0.17369583 0.27986667 0.0000000 -0.27986667 1.133452e-06 1.133452e-06 FALSE TRUE
ENST00000565043 ENSG00000167889 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5B protein_coding nonsense_mediated_decay 1.685521 2.688053 1.492082 0.0417018 0.1019593 -0.844955 0.37278892 0.5832032 0.1727007 0.08022544 0.02101130 -1.6990439 0.21749167 0.21633333 0.1148333 -0.10150000 2.198758e-01 1.133452e-06 TRUE TRUE
ENST00000568598 ENSG00000167889 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5B protein_coding retained_intron 1.685521 2.688053 1.492082 0.0417018 0.1019593 -0.844955 0.10197998 0.3160520 0.0000000 0.31605197 0.00000000 -5.0270300 0.03618750 0.12010000 0.0000000 -0.12010000 8.639385e-01 1.133452e-06 FALSE TRUE
ENST00000569840 ENSG00000167889 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5B protein_coding protein_coding 1.685521 2.688053 1.492082 0.0417018 0.1019593 -0.844955 0.23522990 0.1592803 0.3708906 0.09088418 0.07240000 1.1699628 0.14425417 0.05856667 0.2570667 0.19850000 1.230653e-01 1.133452e-06 FALSE TRUE
MSTRG.15134.5 ENSG00000167889 HEK293_OSMI2_2hA HEK293_TMG_2hB MGAT5B protein_coding   1.685521 2.688053 1.492082 0.0417018 0.1019593 -0.844955 0.20802740 0.4194729 0.2921606 0.14126129 0.06493202 -0.5072515 0.13539167 0.15566667 0.1916000 0.03593333 7.961134e-01 1.133452e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167889 E001 1.2639554 0.011587372 3.974853e-02 9.055776e-02 17 76868404 76868455 52 + 0.532 0.184 -2.188
ENSG00000167889 E002 3.8125945 0.004295597 3.914037e-07 3.534668e-06 17 76868456 76868715 260 + 0.992 0.253 -3.477
ENSG00000167889 E003 1.5071731 0.009036057 7.971971e-04 3.249491e-03 17 76868716 76868823 108 + 0.664 0.102 -3.773
ENSG00000167889 E004 1.7630605 0.019470252 2.779773e-02 6.761417e-02 17 76868824 76868930 107 + 0.624 0.254 -2.015
ENSG00000167889 E005 9.9395279 0.040144433 3.235206e-01 4.668470e-01 17 76868931 76869097 167 + 1.101 0.975 -0.459
ENSG00000167889 E006 0.0000000       17 76872647 76872710 64 +      
ENSG00000167889 E007 0.0000000       17 76872711 76872850 140 +      
ENSG00000167889 E008 11.9105041 0.017954393 3.901198e-01 5.341377e-01 17 76872851 76872963 113 + 1.141 1.064 -0.278
ENSG00000167889 E009 10.4284859 0.004215603 7.375710e-01 8.276997e-01 17 76882151 76882298 148 + 1.042 1.022 -0.073
ENSG00000167889 E010 0.2955422 0.030586432 7.403397e-01   17 76882299 76882527 229 + 0.146 0.102 -0.606
ENSG00000167889 E011 16.1490308 0.001387058 1.228960e-02 3.422876e-02 17 76902555 76902670 116 + 1.026 1.272 0.880
ENSG00000167889 E012 15.5600649 0.002518179 6.224261e-02 1.304129e-01 17 76903303 76903376 74 + 1.058 1.247 0.677
ENSG00000167889 E013 17.3637055 0.001190720 1.537308e-02 4.133445e-02 17 76904252 76904422 171 + 1.073 1.302 0.814
ENSG00000167889 E014 19.3975196 0.001071562 4.970602e-01 6.336191e-01 17 76905169 76905333 165 + 1.232 1.302 0.247
ENSG00000167889 E015 19.8185398 0.001014776 4.819938e-01 6.201637e-01 17 76906018 76906187 170 + 1.242 1.313 0.250
ENSG00000167889 E016 0.1482932 0.043360188 7.377800e-01   17 76913669 76914098 430 + 0.000 0.102 9.384
ENSG00000167889 E017 0.4031496 0.024005999 3.539380e-01 4.982107e-01 17 76923850 76924423 574 + 0.000 0.184 10.404
ENSG00000167889 E018 14.8449589 0.001267977 1.359591e-01 2.424261e-01 17 76924966 76925097 132 + 1.242 1.128 -0.405
ENSG00000167889 E019 17.4671853 0.001732304 2.131808e-02 5.425991e-02 17 76926597 76926730 134 + 1.340 1.169 -0.601
ENSG00000167889 E020 12.8133138 0.001348611 1.557505e-01 2.694334e-01 17 76932645 76932775 131 + 1.189 1.073 -0.415
ENSG00000167889 E021 1.4727282 0.008942432 9.479561e-02 1.825725e-01 17 76933292 76933297 6 + 0.532 0.254 -1.602
ENSG00000167889 E022 17.1799859 0.001175380 1.575923e-01 2.719120e-01 17 76937988 76938143 156 + 1.298 1.198 -0.349
ENSG00000167889 E023 17.9058424 0.001359474 7.428546e-01 8.316765e-01 17 76940402 76940548 147 + 1.251 1.240 -0.039
ENSG00000167889 E024 19.4288098 0.001067632 1.589624e-01 2.737449e-01 17 76940732 76940848 117 + 1.340 1.247 -0.325
ENSG00000167889 E025 0.0000000       17 76943948 76944262 315 +      
ENSG00000167889 E026 0.0000000       17 76946250 76946375 126 +      
ENSG00000167889 E027 13.5212693 0.003251490 2.056854e-01 3.332776e-01 17 76946376 76946450 75 + 1.211 1.110 -0.360
ENSG00000167889 E028 24.5637140 0.007571321 5.593156e-01 6.874403e-01 17 76947830 76948086 257 + 1.399 1.372 -0.094
ENSG00000167889 E029 101.0197867 0.010663767 2.329098e-03 8.240403e-03 17 76948640 76950393 1754 + 1.869 2.041 0.579