ENSG00000167881

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307877 ENSG00000167881 HEK293_OSMI2_2hA HEK293_TMG_2hB SRP68 protein_coding protein_coding 94.12726 110.8157 96.56139 10.8253 2.266352 -0.1986244 45.259735 62.526724 42.35294 5.345430 0.7277061 -0.561901 0.4730083 0.5656333 0.4393333 -0.1263000 2.474404e-04 5.111852e-06 FALSE TRUE
ENST00000539137 ENSG00000167881 HEK293_OSMI2_2hA HEK293_TMG_2hB SRP68 protein_coding protein_coding 94.12726 110.8157 96.56139 10.8253 2.266352 -0.1986244 18.603504 30.125221 14.41349 1.619030 1.2622317 -1.063030 0.1936583 0.2746333 0.1493333 -0.1253000 1.019616e-04 5.111852e-06 FALSE TRUE
ENST00000592704 ENSG00000167881 HEK293_OSMI2_2hA HEK293_TMG_2hB SRP68 protein_coding nonsense_mediated_decay 94.12726 110.8157 96.56139 10.8253 2.266352 -0.1986244 12.161084 1.838472 16.70712 1.838472 2.2138798 3.176921 0.1332042 0.0201000 0.1725667 0.1524667 4.875493e-02 5.111852e-06 FALSE TRUE
MSTRG.15110.7 ENSG00000167881 HEK293_OSMI2_2hA HEK293_TMG_2hB SRP68 protein_coding   94.12726 110.8157 96.56139 10.8253 2.266352 -0.1986244 9.826205 5.318619 16.56446 1.237442 1.7688929 1.637128 0.1084417 0.0478000 0.1709667 0.1231667 5.111852e-06 5.111852e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167881 E001 0.6664265 1.655553e-02 7.202732e-01 8.149208e-01 17 76038775 76038784 10 - 0.248 0.191 -0.480
ENSG00000167881 E002 168.4041685 5.664675e-04 1.155847e-09 1.693124e-08 17 76038785 76039103 319 - 2.085 2.287 0.675
ENSG00000167881 E003 81.7002802 2.615554e-03 9.084066e-05 4.790261e-04 17 76039104 76039105 2 - 1.774 1.977 0.685
ENSG00000167881 E004 1025.7384202 2.716370e-03 1.279597e-09 1.859303e-08 17 76039106 76039441 336 - 2.879 3.057 0.591
ENSG00000167881 E005 596.4745414 2.747474e-03 1.668635e-09 2.372011e-08 17 76039442 76039506 65 - 2.636 2.826 0.635
ENSG00000167881 E006 517.9351952 4.207993e-03 2.121508e-05 1.307673e-04 17 76039507 76039550 44 - 2.594 2.757 0.541
ENSG00000167881 E007 1812.0173540 1.396234e-03 1.143030e-04 5.876035e-04 17 76039551 76039933 383 - 3.192 3.274 0.273
ENSG00000167881 E008 755.5594570 2.057157e-03 5.250024e-02 1.136103e-01 17 76040419 76040474 56 - 2.828 2.888 0.198
ENSG00000167881 E009 16.4329864 1.122010e-02 4.829046e-01 6.210193e-01 17 76040475 76040902 428 - 1.263 1.201 -0.217
ENSG00000167881 E010 707.6444610 2.285034e-04 1.804506e-06 1.417617e-05 17 76040903 76040978 76 - 2.786 2.871 0.284
ENSG00000167881 E011 26.5726212 6.685486e-03 1.770390e-01 2.973940e-01 17 76040979 76041628 650 - 1.486 1.395 -0.312
ENSG00000167881 E012 17.6187507 1.015416e-03 8.676139e-01 9.188511e-01 17 76043375 76043828 454 - 1.244 1.270 0.093
ENSG00000167881 E013 858.7643352 2.148803e-04 5.150138e-07 4.544167e-06 17 76043829 76043958 130 - 2.871 2.953 0.273
ENSG00000167881 E014 6.4840806 9.082465e-03 9.243039e-01 9.563208e-01 17 76044754 76045291 538 - 0.854 0.850 -0.017
ENSG00000167881 E015 666.1303066 1.487088e-04 7.925005e-02 1.583157e-01 17 76045292 76045386 95 - 2.791 2.830 0.130
ENSG00000167881 E016 939.7048710 1.709075e-04 8.326348e-01 8.951371e-01 17 76046038 76046194 157 - 2.954 2.970 0.051
ENSG00000167881 E017 720.3646898 1.271462e-04 4.299933e-02 9.654057e-02 17 76047906 76047970 65 - 2.858 2.843 -0.052
ENSG00000167881 E018 2.4839156 6.441270e-03 8.783493e-02 1.718394e-01 17 76047971 76049647 1677 - 0.685 0.423 -1.219
ENSG00000167881 E019 873.0239210 8.584024e-05 9.189182e-07 7.687049e-06 17 76050428 76050526 99 - 2.961 2.913 -0.161
ENSG00000167881 E020 0.9859167 4.537147e-02 2.350988e-01 3.684604e-01 17 76053449 76053656 208 - 0.404 0.191 -1.474
ENSG00000167881 E021 2.4462616 1.471741e-01 8.922221e-01 9.351421e-01 17 76057397 76057402 6 - 0.521 0.538 0.081
ENSG00000167881 E022 974.4820800 1.375211e-04 1.113954e-04 5.741363e-04 17 76057403 76057543 141 - 3.001 2.965 -0.119
ENSG00000167881 E023 697.1637177 1.202033e-04 1.249986e-05 8.122871e-05 17 76060308 76060390 83 - 2.864 2.814 -0.164
ENSG00000167881 E024 1.9833729 7.870960e-03 2.370946e-01 3.708214e-01 17 76060391 76060742 352 - 0.567 0.376 -0.965
ENSG00000167881 E025 496.5397262 1.456596e-04 1.503422e-03 5.646907e-03 17 76061110 76061149 40 - 2.711 2.670 -0.135
ENSG00000167881 E026 439.5197923 1.228471e-03 1.035756e-02 2.964450e-02 17 76061150 76061174 25 - 2.664 2.610 -0.179
ENSG00000167881 E027 500.9702392 1.799985e-03 4.006896e-02 9.115732e-02 17 76061175 76061219 45 - 2.716 2.669 -0.158
ENSG00000167881 E028 1.2470141 1.164719e-02 4.956267e-01 6.324037e-01 17 76061220 76061491 272 - 0.248 0.376 0.843
ENSG00000167881 E029 577.2894753 2.173094e-03 2.760491e-02 6.722282e-02 17 76061492 76061574 83 - 2.782 2.727 -0.182
ENSG00000167881 E030 2.4074501 1.561634e-01 2.122554e-01 3.411862e-01 17 76061575 76061653 79 - 0.334 0.623 1.465
ENSG00000167881 E031 575.2123003 1.300753e-03 2.764796e-06 2.086073e-05 17 76063976 76064037 62 - 2.807 2.708 -0.328
ENSG00000167881 E032 777.3091341 1.561911e-03 1.070245e-05 7.065408e-05 17 76064038 76064171 134 - 2.934 2.841 -0.310
ENSG00000167881 E033 623.6700938 1.642648e-03 4.228913e-05 2.423703e-04 17 76067217 76067312 96 - 2.838 2.747 -0.302
ENSG00000167881 E034 358.7060881 1.395333e-03 1.619685e-03 6.024001e-03 17 76067313 76067330 18 - 2.588 2.515 -0.242
ENSG00000167881 E035 295.2709272 1.948829e-04 1.140536e-06 9.356161e-06 17 76070378 76070383 6 - 2.516 2.425 -0.305
ENSG00000167881 E036 429.3650626 2.391426e-03 5.069981e-04 2.186466e-03 17 76070384 76070436 53 - 2.678 2.584 -0.313
ENSG00000167881 E037 288.6877241 3.351649e-03 2.547659e-02 6.286176e-02 17 76070437 76070444 8 - 2.492 2.421 -0.238
ENSG00000167881 E038 353.2441095 5.896685e-03 7.598414e-02 1.530856e-01 17 76072308 76072344 37 - 2.578 2.508 -0.232
ENSG00000167881 E039 332.5655353 9.269132e-03 5.456618e-02 1.172307e-01 17 76072345 76072517 173 - 2.566 2.471 -0.314