ENSG00000167778

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301463 ENSG00000167778 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRYD3 protein_coding protein_coding 14.99442 24.29899 10.52861 0.9390188 0.3137415 -1.205805 13.3715544 23.1101450 8.6704493 0.7153528 0.1377837 -1.4133088 0.87336250 0.95163333 0.82546667 -0.12616667 0.0004406891 8.334134e-07 FALSE TRUE
MSTRG.7340.3 ENSG00000167778 HEK293_OSMI2_2hA HEK293_TMG_2hB SPRYD3 protein_coding   14.99442 24.29899 10.52861 0.9390188 0.3137415 -1.205805 0.7542393 0.7037023 0.8416167 0.2141158 0.2892377 0.2548817 0.05863333 0.02846667 0.07853333 0.05006667 0.1178910327 8.334134e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167778 E001 56.0492597 0.0019254786 1.987890e-02 5.123250e-02 12 53064316 53064617 302 - 1.568 1.713 0.495
ENSG00000167778 E002 222.8355155 0.0045643864 1.267810e-03 4.869985e-03 12 53064618 53064950 333 - 2.158 2.303 0.487
ENSG00000167778 E003 255.6508051 0.0007069860 5.340975e-05 2.988104e-04 12 53064951 53065274 324 - 2.236 2.357 0.405
ENSG00000167778 E004 317.2630742 0.0013938346 1.648572e-02 4.381060e-02 12 53065275 53065660 386 - 2.367 2.440 0.243
ENSG00000167778 E005 112.1066871 0.0044801157 3.222294e-01 4.655369e-01 12 53065661 53065701 41 - 2.010 1.967 -0.145
ENSG00000167778 E006 239.8505857 0.0008841241 7.852165e-02 1.571175e-01 12 53065702 53065966 265 - 2.261 2.318 0.189
ENSG00000167778 E007 207.7713298 0.0005532722 7.168065e-01 8.123618e-01 12 53066314 53066486 173 - 2.248 2.243 -0.017
ENSG00000167778 E008 101.9433762 0.0002926315 7.571078e-03 2.269670e-02 12 53066573 53066601 29 - 2.010 1.912 -0.329
ENSG00000167778 E009 156.9897061 0.0003721428 2.120555e-02 5.402393e-02 12 53066602 53066692 91 - 2.175 2.108 -0.227
ENSG00000167778 E010 123.1437041 0.0003181950 3.732759e-01 5.177208e-01 12 53067648 53067705 58 - 2.037 2.010 -0.091
ENSG00000167778 E011 191.9433334 0.0010127357 2.608910e-01 3.984796e-01 12 53068155 53068290 136 - 2.230 2.200 -0.100
ENSG00000167778 E012 91.4051083 0.0003497596 3.046488e-01 4.466709e-01 12 53068291 53068304 14 - 1.918 1.880 -0.127
ENSG00000167778 E013 1.2835352 0.0133722219 3.345188e-02 7.868097e-02 12 53073160 53073285 126 - 0.571 0.200 -2.223
ENSG00000167778 E014 164.8524795 0.0002689257 6.596111e-01 7.683923e-01 12 53073286 53073471 186 - 2.129 2.148 0.065
ENSG00000167778 E015 155.1143243 0.0006763907 5.020975e-02 1.095257e-01 12 53074649 53074784 136 - 2.161 2.101 -0.201
ENSG00000167778 E016 6.0077710 0.0027255647 2.287798e-06 1.756785e-05 12 53074785 53075094 310 - 1.148 0.571 -2.264
ENSG00000167778 E017 127.2966564 0.0004919380 1.064802e-01 2.003591e-01 12 53075095 53075219 125 - 2.068 2.015 -0.178
ENSG00000167778 E018 101.3044744 0.0004401115 9.362288e-02 1.807899e-01 12 53075736 53075811 76 - 1.976 1.915 -0.208
ENSG00000167778 E019 138.1687479 0.0021269888 5.350316e-02 1.153860e-01 12 53077115 53077261 147 - 2.116 2.046 -0.236
ENSG00000167778 E020 0.4031496 0.0250385266 6.679410e-01 7.750697e-01 12 53078061 53078171 111 - 0.001 0.143 8.066
ENSG00000167778 E021 83.2737982 0.0027005564 5.017440e-02 1.094713e-01 12 53079311 53079404 94 - 1.912 1.822 -0.304