ENSG00000167721

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301364 ENSG00000167721 HEK293_OSMI2_2hA HEK293_TMG_2hB TSR1 protein_coding protein_coding 50.93716 40.70193 69.01007 4.726211 0.62917 0.7615643 44.8942 38.16744 59.27125 4.417672 1.243526 0.6348555 0.8832417 0.9377333 0.8587 -0.07903333 2.532363e-07 2.476585e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167721 E001 1994.25945 0.0032323809 4.716101e-02 1.041149e-01 17 2322396 2324374 1979 - 3.281 3.321 0.132
ENSG00000167721 E002 649.46064 0.0015950784 4.971684e-13 1.280760e-11 17 2324504 2324578 75 - 2.731 2.892 0.534
ENSG00000167721 E003 302.55830 0.0001592408 5.711557e-12 1.236897e-10 17 2324689 2324690 2 - 2.416 2.554 0.460
ENSG00000167721 E004 625.27903 0.0003378752 6.543671e-14 1.908666e-12 17 2324691 2324829 139 - 2.742 2.858 0.386
ENSG00000167721 E005 574.41530 0.0003450964 1.335311e-07 1.324107e-06 17 2325304 2325420 117 - 2.724 2.807 0.277
ENSG00000167721 E006 553.01497 0.0001224409 8.505827e-10 1.276460e-08 17 2329343 2329475 133 - 2.703 2.793 0.299
ENSG00000167721 E007 482.31465 0.0002103788 4.532648e-05 2.580839e-04 17 2330515 2330625 111 - 2.657 2.722 0.214
ENSG00000167721 E008 618.92917 0.0001706003 3.907199e-02 8.933012e-02 17 2330947 2331109 163 - 2.785 2.811 0.085
ENSG00000167721 E009 774.91854 0.0007069768 1.608625e-01 2.762412e-01 17 2332169 2332359 191 - 2.909 2.877 -0.107
ENSG00000167721 E010 797.92025 0.0005315108 1.777910e-02 4.666063e-02 17 2332961 2333124 164 - 2.928 2.881 -0.155
ENSG00000167721 E011 11.04696 0.0069509251 4.594251e-07 4.092763e-06 17 2333390 2333556 167 - 0.726 1.279 2.059
ENSG00000167721 E012 644.83816 0.0013448779 3.658674e-01 5.101796e-01 17 2333557 2333716 160 - 2.828 2.795 -0.109
ENSG00000167721 E013 774.02082 0.0013758777 6.042649e-06 4.223122e-05 17 2334472 2334784 313 - 2.941 2.831 -0.364
ENSG00000167721 E014 458.96967 0.0015159121 1.147304e-10 2.004918e-09 17 2334785 2334896 112 - 2.740 2.569 -0.568
ENSG00000167721 E015 347.37703 0.0021706518 2.801643e-08 3.172711e-07 17 2335260 2335307 48 - 2.621 2.445 -0.585
ENSG00000167721 E016 389.33496 0.0014450152 3.202360e-08 3.585140e-07 17 2335308 2335394 87 - 2.661 2.510 -0.504
ENSG00000167721 E017 271.03299 0.0013013207 1.192429e-07 1.194490e-06 17 2335511 2335564 54 - 2.506 2.351 -0.518
ENSG00000167721 E018 418.33052 0.0062841512 1.218422e-03 4.702682e-03 17 2335565 2335730 166 - 2.691 2.538 -0.510
ENSG00000167721 E019 293.72163 0.0089079991 3.843261e-03 1.270161e-02 17 2336037 2336140 104 - 2.542 2.378 -0.545
ENSG00000167721 E020 27.79350 0.0006999436 6.978214e-12 1.491596e-10 17 2336141 2336330 190 - 1.637 1.142 -1.721
ENSG00000167721 E021 201.88421 0.0055447089 1.331956e-02 3.666434e-02 17 2336331 2336657 327 - 2.365 2.238 -0.422