ENSG00000167716

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409644 ENSG00000167716 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR81 protein_coding protein_coding 13.68542 22.06166 8.520472 1.834619 0.6537717 -1.371498 5.7138550 7.301241 4.6421170 1.0117967 0.23375918 -0.6522290 0.45117500 0.32880000 0.5470333 0.218233333 0.0001989997 0.0001989997 FALSE TRUE
ENST00000446363 ENSG00000167716 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR81 protein_coding protein_coding 13.68542 22.06166 8.520472 1.834619 0.6537717 -1.371498 0.5138501 1.697911 0.0000000 1.3307553 0.00000000 -7.4160886 0.02601667 0.08726667 0.0000000 -0.087266667 0.3352357945 0.0001989997 FALSE TRUE
ENST00000464528 ENSG00000167716 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR81 protein_coding retained_intron 13.68542 22.06166 8.520472 1.834619 0.6537717 -1.371498 1.4457113 2.155123 0.5398294 0.1852449 0.13691053 -1.9773929 0.10348333 0.09823333 0.0665000 -0.031733333 0.4769473152 0.0001989997 TRUE TRUE
ENST00000495411 ENSG00000167716 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR81 protein_coding retained_intron 13.68542 22.06166 8.520472 1.834619 0.6537717 -1.371498 1.4182211 1.496440 1.2738293 0.6163135 0.43258791 -0.2306895 0.11292917 0.06463333 0.1435000 0.078866667 0.4022556053 0.0001989997 FALSE TRUE
MSTRG.13373.17 ENSG00000167716 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR81 protein_coding   13.68542 22.06166 8.520472 1.834619 0.6537717 -1.371498 1.6988277 2.894096 1.0208378 0.6454276 0.09594198 -1.4942716 0.12245833 0.12800000 0.1196333 -0.008366667 0.9438099318 0.0001989997 TRUE TRUE
MSTRG.13373.19 ENSG00000167716 HEK293_OSMI2_2hA HEK293_TMG_2hB WDR81 protein_coding   13.68542 22.06166 8.520472 1.834619 0.6537717 -1.371498 0.5808703 1.479647 0.1057205 0.6445580 0.10572046 -3.6862542 0.03407083 0.06293333 0.0126000 -0.050333333 0.2468349555 0.0001989997 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167716 E001 0.1817044 0.0396862877 1.000000e+00   17 1716523 1716535 13 + 0.000 0.079 10.733
ENSG00000167716 E002 0.1817044 0.0396862877 1.000000e+00   17 1716536 1716546 11 + 0.000 0.079 10.728
ENSG00000167716 E003 0.5483223 0.0200115467 8.158694e-01 8.834501e-01 17 1716547 1716600 54 + 0.185 0.146 -0.413
ENSG00000167716 E004 0.7697675 0.0248797391 9.297061e-01 9.597220e-01 17 1716601 1716633 33 + 0.185 0.204 0.175
ENSG00000167716 E005 0.2214452 0.0373146599 1.000000e+00   17 1716634 1716714 81 + 0.000 0.079 10.731
ENSG00000167716 E006 0.8136886 0.1568015528 1.704889e-01 2.887904e-01 17 1724540 1724689 150 + 0.415 0.146 -1.998
ENSG00000167716 E007 0.0000000       17 1724690 1724703 14 +      
ENSG00000167716 E008 2.2667102 0.1163268802 7.244279e-03 2.185953e-02 17 1724704 1724748 45 + 0.801 0.256 -2.727
ENSG00000167716 E009 4.2908707 0.0043884432 7.671254e-07 6.533304e-06 17 1724749 1724786 38 + 1.066 0.379 -2.930
ENSG00000167716 E010 316.4455909 0.0053448351 7.170970e-11 1.296296e-09 17 1724787 1726798 2012 + 2.602 2.358 -0.815
ENSG00000167716 E011 91.0969817 0.0171240072 2.948120e-01 4.359179e-01 17 1726799 1726985 187 + 1.952 1.872 -0.271
ENSG00000167716 E012 163.6075324 0.0047023515 5.926977e-02 1.253864e-01 17 1726986 1727573 588 + 2.201 2.121 -0.267
ENSG00000167716 E013 144.5819791 0.0020419854 6.424606e-02 1.337762e-01 17 1727574 1727989 416 + 2.139 2.068 -0.239
ENSG00000167716 E014 103.2365836 0.0003232426 7.157978e-01 8.116288e-01 17 1727990 1728209 220 + 1.958 1.940 -0.061
ENSG00000167716 E015 94.8533968 0.0097575851 5.473195e-02 1.175282e-01 17 1728210 1728403 194 + 1.997 1.878 -0.399
ENSG00000167716 E016 47.2127614 0.0018332377 7.385624e-03 2.222056e-02 17 1728404 1728422 19 + 1.725 1.567 -0.536
ENSG00000167716 E017 114.2171910 0.0003680282 3.922067e-01 5.361502e-01 17 1728423 1728626 204 + 1.961 1.990 0.099
ENSG00000167716 E018 79.6217976 0.0049197663 4.884591e-01 6.260152e-01 17 1730380 1730460 81 + 1.797 1.838 0.138
ENSG00000167716 E019 51.8709699 0.0068056240 7.951474e-01 8.691440e-01 17 1730461 1730470 10 + 1.660 1.643 -0.058
ENSG00000167716 E020 56.0976752 0.0091394077 9.311859e-01 9.606577e-01 17 1730471 1730487 17 + 1.675 1.682 0.027
ENSG00000167716 E021 4.4878198 0.0037957630 9.519823e-01 9.739446e-01 17 1730488 1730754 267 + 0.674 0.680 0.025
ENSG00000167716 E022 127.3006086 0.0011862048 9.764378e-01 9.892626e-01 17 1730755 1730945 191 + 2.035 2.031 -0.012
ENSG00000167716 E023 94.9977933 0.0003443069 1.057738e-01 1.992744e-01 17 1731068 1731183 116 + 1.956 1.886 -0.233
ENSG00000167716 E024 79.2202868 0.0004700301 4.290206e-02 9.635987e-02 17 1731184 1731258 75 + 1.895 1.802 -0.313
ENSG00000167716 E025 102.5858072 0.0007982504 5.071552e-01 6.427507e-01 17 1732325 1732490 166 + 1.958 1.928 -0.101
ENSG00000167716 E026 71.6141580 0.0019750820 2.088034e-02 5.333599e-02 17 1732666 1732776 111 + 1.684 1.807 0.416
ENSG00000167716 E027 50.1093223 0.0004875392 1.246060e-02 3.464322e-02 17 1732777 1732831 55 + 1.517 1.663 0.499
ENSG00000167716 E028 15.0459868 0.0312397411 5.271025e-02 1.139762e-01 17 1732832 1732947 116 + 1.303 1.062 -0.860
ENSG00000167716 E029 11.0930604 0.0508340413 1.790249e-01 2.999162e-01 17 1732948 1732977 30 + 1.155 0.952 -0.741
ENSG00000167716 E030 29.5932231 0.0078822900 5.705215e-01 6.969717e-01 17 1733303 1733526 224 + 1.440 1.394 -0.159
ENSG00000167716 E031 100.9937199 0.0016658707 7.128199e-04 2.944521e-03 17 1733527 1733726 200 + 1.811 1.966 0.521
ENSG00000167716 E032 123.5284367 0.0022616079 7.710223e-02 1.548461e-01 17 1733727 1733951 225 + 1.966 2.040 0.248
ENSG00000167716 E033 148.4281027 0.0015966653 8.110775e-02 1.612762e-01 17 1733952 1734216 265 + 2.052 2.116 0.215
ENSG00000167716 E034 4.5372117 0.0054327479 6.993871e-01 7.991604e-01 17 1734217 1734230 14 + 0.622 0.681 0.250
ENSG00000167716 E035 102.0727445 0.0017694954 1.931758e-03 7.014196e-03 17 1735572 1735717 146 + 1.829 1.970 0.473
ENSG00000167716 E036 18.6045670 0.0010188516 5.693410e-01 6.959155e-01 17 1735718 1736038 321 + 1.186 1.234 0.169
ENSG00000167716 E037 96.4848828 0.0015152099 4.348559e-03 1.411862e-02 17 1736039 1736135 97 + 1.815 1.944 0.435
ENSG00000167716 E038 102.7331490 0.0003197697 4.677695e-03 1.503368e-02 17 1736136 1736218 83 + 1.849 1.963 0.385
ENSG00000167716 E039 603.6449710 0.0075970442 1.459601e-04 7.297384e-04 17 1737365 1738599 1235 + 2.589 2.742 0.509