ENSG00000167703

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301335 ENSG00000167703 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC43A2 protein_coding protein_coding 8.840781 13.45101 6.577838 1.021094 0.261425 -1.03091 0.6488162 0.8804993 0.5418747 0.06501634 0.02149278 -0.6902737 0.07535833 0.06596667 0.08253333 0.01656667 5.785239e-01 1.041295e-19 FALSE TRUE
ENST00000571650 ENSG00000167703 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC43A2 protein_coding protein_coding 8.840781 13.45101 6.577838 1.021094 0.261425 -1.03091 4.5925201 7.8126775 3.1785534 0.30417022 0.33740570 -1.2947604 0.50183750 0.58516667 0.48296667 -0.10220000 3.736419e-01 1.041295e-19 FALSE TRUE
MSTRG.13365.11 ENSG00000167703 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC43A2 protein_coding   8.840781 13.45101 6.577838 1.021094 0.261425 -1.03091 0.1584684 0.1935525 0.4550628 0.19355253 0.45506276 1.1920243 0.02265833 0.01360000 0.06856667 0.05496667 9.545260e-01 1.041295e-19 TRUE TRUE
MSTRG.13365.3 ENSG00000167703 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC43A2 protein_coding   8.840781 13.45101 6.577838 1.021094 0.261425 -1.03091 0.9962425 1.7290937 0.0000000 0.12235174 0.00000000 -7.4421919 0.11373333 0.12873333 0.00000000 -0.12873333 1.041295e-19 1.041295e-19 FALSE TRUE
MSTRG.13365.5 ENSG00000167703 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC43A2 protein_coding   8.840781 13.45101 6.577838 1.021094 0.261425 -1.03091 1.2746382 2.2340014 1.5177844 0.57304957 0.47210756 -0.5546326 0.13957917 0.16246667 0.23543333 0.07296667 7.906625e-01 1.041295e-19 FALSE TRUE
MSTRG.13365.8 ENSG00000167703 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC43A2 protein_coding   8.840781 13.45101 6.577838 1.021094 0.261425 -1.03091 0.5384435 0.1575190 0.6584999 0.15751896 0.65849993 1.9966030 0.07001250 0.01073333 0.09410000 0.08336667 9.557911e-01 1.041295e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167703 E001 86.6166957 0.0003632132 2.553783e-02 6.299154e-02 17 1569268 1574371 5104 - 1.948 1.863 -0.285
ENSG00000167703 E002 259.2014608 0.0018299217 3.457355e-04 1.562913e-03 17 1574372 1575291 920 - 2.271 2.386 0.384
ENSG00000167703 E003 60.3659317 0.0108750779 1.442337e-01 2.537648e-01 17 1575292 1575372 81 - 1.647 1.761 0.385
ENSG00000167703 E004 43.8729784 0.0152554441 8.188306e-02 1.625145e-01 17 1575373 1575400 28 - 1.476 1.636 0.546
ENSG00000167703 E005 62.5508642 0.0017025989 9.060561e-02 1.760834e-01 17 1575401 1575481 81 - 1.675 1.772 0.328
ENSG00000167703 E006 47.2668120 0.0007458762 4.324985e-01 5.749378e-01 17 1575482 1575500 19 - 1.590 1.640 0.172
ENSG00000167703 E007 47.9173123 0.0005230987 7.671236e-02 1.542315e-01 17 1575501 1575514 14 - 1.549 1.657 0.368
ENSG00000167703 E008 128.0129843 0.0004444596 1.325874e-03 5.061962e-03 17 1575515 1575765 251 - 1.958 2.080 0.410
ENSG00000167703 E009 46.6882668 0.0005835666 2.061228e-01 3.338378e-01 17 1576597 1576602 6 - 1.555 1.634 0.271
ENSG00000167703 E010 93.6079476 0.0029775440 8.851410e-01 9.305674e-01 17 1576603 1576720 118 - 1.907 1.921 0.045
ENSG00000167703 E011 52.0293209 0.0016040935 8.072532e-01 8.775662e-01 17 1578250 1578253 4 - 1.652 1.671 0.066
ENSG00000167703 E012 76.3517235 0.0006338465 5.155922e-01 6.502419e-01 17 1578254 1578323 70 - 1.805 1.840 0.119
ENSG00000167703 E013 0.6255398 0.0192473140 8.504821e-01 9.072398e-01 17 1578324 1578705 382 - 0.176 0.214 0.351
ENSG00000167703 E014 99.1279432 0.0005056321 8.367108e-01 8.978682e-01 17 1583204 1583336 133 - 1.941 1.938 -0.009
ENSG00000167703 E015 0.9964241 0.0128121884 8.443858e-01 9.031576e-01 17 1583337 1583698 362 - 0.300 0.267 -0.231
ENSG00000167703 E016 2.6258646 0.0058235141 9.243449e-02 1.789187e-01 17 1585239 1585912 674 - 0.698 0.431 -1.231
ENSG00000167703 E017 82.3856316 0.0050721191 7.620377e-01 8.457451e-01 17 1585913 1586051 139 - 1.841 1.866 0.084
ENSG00000167703 E018 0.0000000       17 1586949 1586960 12 -      
ENSG00000167703 E019 47.6249682 0.0077016710 7.991272e-01 8.718642e-01 17 1590802 1590849 48 - 1.606 1.630 0.082
ENSG00000167703 E020 50.7124203 0.0016900037 4.886769e-01 6.262066e-01 17 1590850 1590906 57 - 1.617 1.662 0.154
ENSG00000167703 E021 46.1939651 0.0007669906 7.301746e-02 1.483632e-01 17 1590907 1590948 42 - 1.524 1.637 0.385
ENSG00000167703 E022 96.7771852 0.0003092371 4.693220e-01 6.085838e-01 17 1591269 1591439 171 - 1.905 1.939 0.115
ENSG00000167703 E023 60.5357814 0.0021913296 7.471686e-01 8.347384e-01 17 1591440 1591471 32 - 1.711 1.735 0.082
ENSG00000167703 E024 63.8653362 0.0007157108 7.807309e-01 8.591160e-01 17 1591566 1591621 56 - 1.758 1.750 -0.027
ENSG00000167703 E025 72.5925283 0.0003985730 1.278330e-03 4.904926e-03 17 1591622 1591699 78 - 1.902 1.766 -0.457
ENSG00000167703 E026 83.3378164 0.0004178112 5.505584e-06 3.881713e-05 17 1593187 1593279 93 - 1.990 1.811 -0.601
ENSG00000167703 E027 0.0000000       17 1603105 1603207 103 -      
ENSG00000167703 E028 0.0000000       17 1604740 1605085 346 -      
ENSG00000167703 E029 0.0000000       17 1605193 1605276 84 -      
ENSG00000167703 E030 63.2876911 0.0004571346 1.272762e-06 1.033656e-05 17 1613195 1613271 77 - 1.899 1.683 -0.730
ENSG00000167703 E031 46.9201966 0.0005222484 1.059523e-01 1.995461e-01 17 1614979 1615034 56 - 1.680 1.596 -0.285
ENSG00000167703 E032 0.0000000       17 1616366 1616561 196 -      
ENSG00000167703 E033 49.1505322 0.0016371497 7.455481e-01 8.335607e-01 17 1616562 1616630 69 - 1.652 1.639 -0.045
ENSG00000167703 E034 48.3365881 0.0005246692 8.502268e-02 1.674407e-01 17 1616631 1616716 86 - 1.698 1.610 -0.298
ENSG00000167703 E035 39.5774477 0.0012949741 6.175039e-02 1.295722e-01 17 1616717 1616769 53 - 1.627 1.520 -0.367
ENSG00000167703 E036 0.0000000       17 1625836 1625940 105 -      
ENSG00000167703 E037 47.4200724 0.0006397811 1.383022e-04 6.961114e-04 17 1627715 1627920 206 - 1.762 1.565 -0.670
ENSG00000167703 E038 1.0716524 0.0116501643 8.466536e-01 9.046847e-01 17 1628081 1628113 33 - 0.300 0.267 -0.229
ENSG00000167703 E039 2.7969980 0.2654428499 6.197706e-01 7.370937e-01 17 1628114 1628341 228 - 0.602 0.519 -0.381
ENSG00000167703 E040 9.7625821 0.0378001029 1.356076e-02 3.721582e-02 17 1628794 1628886 93 - 1.190 0.870 -1.174