ENSG00000167699

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301329 ENSG00000167699 HEK293_OSMI2_2hA HEK293_TMG_2hB GLOD4 protein_coding protein_coding 71.02343 60.43178 94.92953 9.591929 2.856775 0.6514628 57.735541 55.336283 67.69129 9.869368 2.047861 0.2906969 0.82968333 0.91096667 0.7131000 -0.1978667 5.045391e-05 5.045391e-05 FALSE TRUE
ENST00000576419 ENSG00000167699 HEK293_OSMI2_2hA HEK293_TMG_2hB GLOD4 protein_coding protein_coding 71.02343 60.43178 94.92953 9.591929 2.856775 0.6514628 5.938279 1.240168 16.32317 1.240168 1.092788 3.7076107 0.06714583 0.02263333 0.1715667 0.1489333 5.779513e-02 5.045391e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167699 E001 4.1525146 0.0086165020 4.676152e-01 6.071166e-01 17 757097 757321 225 - 0.665 0.771 0.438
ENSG00000167699 E002 3.8016260 0.0084525447 6.521474e-03 1.997855e-02 17 759323 759329 7 - 0.449 0.863 1.796
ENSG00000167699 E003 46.6639747 0.0004707177 7.386936e-07 6.314276e-06 17 759330 759451 122 - 1.538 1.797 0.881
ENSG00000167699 E004 975.9557784 0.0006839280 6.825461e-11 1.239041e-09 17 759452 760021 570 - 2.941 3.042 0.336
ENSG00000167699 E005 393.4948063 0.0001309820 1.763371e-04 8.625268e-04 17 760022 760063 42 - 2.568 2.638 0.235
ENSG00000167699 E006 319.3404593 0.0001592030 2.043718e-01 3.316227e-01 17 760064 760072 9 - 2.499 2.528 0.095
ENSG00000167699 E007 366.2224543 0.0001357021 5.049924e-01 6.408329e-01 17 760073 760097 25 - 2.565 2.581 0.052
ENSG00000167699 E008 336.2961792 0.0001337674 6.456045e-01 7.576900e-01 17 760098 760110 13 - 2.531 2.543 0.040
ENSG00000167699 E009 539.9234057 0.0001630461 8.724620e-01 9.219755e-01 17 760111 760187 77 - 2.742 2.743 0.003
ENSG00000167699 E010 494.7730134 0.0004412396 7.661372e-01 8.487158e-01 17 760188 760238 51 - 2.700 2.709 0.029
ENSG00000167699 E011 591.2391234 0.0004364190 9.085810e-01 9.459052e-01 17 769869 769955 87 - 2.779 2.783 0.013
ENSG00000167699 E012 577.5460269 0.0002166128 6.186065e-01 7.361958e-01 17 770044 770157 114 - 2.774 2.769 -0.016
ENSG00000167699 E013 7.1677309 0.0802611597 4.267609e-01 5.695687e-01 17 770158 770224 67 - 0.977 0.855 -0.460
ENSG00000167699 E014 8.1000609 0.0021301426 6.371884e-01 7.511165e-01 17 770225 770420 196 - 0.989 0.940 -0.182
ENSG00000167699 E015 239.2230172 0.0025881155 5.111200e-01 6.462269e-01 17 770421 770428 8 - 2.398 2.379 -0.062
ENSG00000167699 E016 401.4274468 0.0009873882 3.810595e-01 5.253472e-01 17 770429 770507 79 - 2.602 2.622 0.067
ENSG00000167699 E017 16.7474733 0.0111589154 2.295481e-04 1.090123e-03 17 770508 771324 817 - 1.401 1.034 -1.301
ENSG00000167699 E018 492.3976793 0.0012096158 9.115181e-01 9.478362e-01 17 771325 771450 126 - 2.700 2.697 -0.010
ENSG00000167699 E019 239.0299073 0.0006066802 4.033032e-01 5.470756e-01 17 771451 771461 11 - 2.376 2.397 0.069
ENSG00000167699 E020 591.4039808 0.0004841603 1.377260e-01 2.449105e-01 17 775775 775919 145 - 2.793 2.765 -0.091
ENSG00000167699 E021 324.4492279 0.0001856329 1.188785e-03 4.603485e-03 17 776868 776880 13 - 2.551 2.489 -0.207
ENSG00000167699 E022 627.1014893 0.0005683563 2.807800e-03 9.697890e-03 17 776881 776988 108 - 2.831 2.775 -0.186
ENSG00000167699 E023 29.3973749 0.0025753246 1.855601e-04 9.015647e-04 17 776989 777692 704 - 1.595 1.337 -0.888
ENSG00000167699 E024 11.0339698 0.0015210749 4.347611e-03 1.411603e-02 17 778302 778422 121 - 1.207 0.923 -1.034
ENSG00000167699 E025 14.7353085 0.0089889001 1.913253e-04 9.267469e-04 17 778423 778621 199 - 1.351 0.974 -1.350
ENSG00000167699 E026 9.7456031 0.0345598689 1.425883e-02 3.881391e-02 17 778622 778640 19 - 1.173 0.821 -1.305
ENSG00000167699 E027 9.8822550 0.0042229284 5.608909e-03 1.757598e-02 17 778641 778661 21 - 1.164 0.864 -1.105
ENSG00000167699 E028 9.2888021 0.0074282059 1.869219e-01 3.098633e-01 17 778662 778694 33 - 1.085 0.940 -0.536
ENSG00000167699 E029 423.1748813 0.0011961473 3.195313e-03 1.084202e-02 17 778695 778744 50 - 2.668 2.594 -0.248
ENSG00000167699 E030 3.8738120 0.0065708288 8.972842e-01 9.384022e-01 17 778745 778789 45 - 0.692 0.716 0.099
ENSG00000167699 E031 0.9535497 0.1968135911 8.319456e-01 8.946957e-01 17 778790 778810 21 - 0.279 0.311 0.211
ENSG00000167699 E032 1.9824425 0.1358779712 5.686726e-01 6.952914e-01 17 780618 780683 66 - 0.533 0.386 -0.751
ENSG00000167699 E033 3.4677559 0.0053395453 3.504285e-01 4.945995e-01 17 780684 780738 55 - 0.718 0.581 -0.590
ENSG00000167699 E034 4.1727904 0.0038137510 6.801525e-01 7.841213e-01 17 781863 781923 61 - 0.742 0.687 -0.230
ENSG00000167699 E035 4.3911152 0.0048838015 5.697077e-01 6.962334e-01 17 781924 782043 120 - 0.766 0.687 -0.322
ENSG00000167699 E036 6.3140215 0.0028349150 5.116099e-01 6.465927e-01 17 782044 782165 122 - 0.900 0.821 -0.306
ENSG00000167699 E037 416.3532589 0.0017354160 6.504981e-03 1.993480e-02 17 782166 782294 129 - 2.662 2.584 -0.259