ENSG00000167693

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336868 ENSG00000167693 HEK293_OSMI2_2hA HEK293_TMG_2hB NXN protein_coding protein_coding 31.50176 57.52034 18.54102 3.241024 0.6788301 -1.632825 20.350089 31.835607 15.5980418 4.6511191 0.9109927 -1.0288048 0.67653333 0.54873333 0.84000000 0.29126667 0.0002429176 0.0002429176 FALSE TRUE
ENST00000571684 ENSG00000167693 HEK293_OSMI2_2hA HEK293_TMG_2hB NXN protein_coding protein_coding 31.50176 57.52034 18.54102 3.241024 0.6788301 -1.632825 1.467874 1.606569 0.8367302 0.3685736 0.4999851 -0.9329606 0.05614583 0.02766667 0.04400000 0.01633333 0.9918750886 0.0002429176 FALSE TRUE
ENST00000575801 ENSG00000167693 HEK293_OSMI2_2hA HEK293_TMG_2hB NXN protein_coding protein_coding 31.50176 57.52034 18.54102 3.241024 0.6788301 -1.632825 7.620512 21.737716 0.9537921 2.5945756 0.6450912 -4.4959981 0.18332500 0.38236667 0.05366667 -0.32870000 0.1035165902 0.0002429176 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167693 E001 1.1500158 0.0111432378 2.644814e-01 4.024483e-01 17 799310 799312 3 - 0.438 0.238 -1.258
ENSG00000167693 E002 1184.2189601 0.0023093028 2.064845e-06 1.601419e-05 17 799313 800387 1075 - 2.883 3.004 0.402
ENSG00000167693 E003 283.3605650 0.0002695157 5.554051e-01 6.842677e-01 17 800388 800480 93 - 2.362 2.356 -0.019
ENSG00000167693 E004 501.4666001 0.0001873679 8.013433e-02 1.597545e-01 17 800481 800767 287 - 2.624 2.600 -0.078
ENSG00000167693 E005 212.4777152 0.0002527001 9.595744e-01 9.786162e-01 17 800768 800787 20 - 2.225 2.235 0.036
ENSG00000167693 E006 622.0879081 0.0001332562 4.627339e-02 1.025365e-01 17 800788 801131 344 - 2.663 2.707 0.146
ENSG00000167693 E007 2.9484596 0.0055510859 5.813156e-01 7.058604e-01 17 802997 803095 99 - 0.592 0.504 -0.408
ENSG00000167693 E008 336.0064057 0.0001853868 7.091367e-01 8.066081e-01 17 803682 803806 125 - 2.429 2.430 0.002
ENSG00000167693 E009 1.8401748 0.1379260781 4.935495e-01 6.305610e-01 17 803807 803984 178 - 0.521 0.357 -0.865
ENSG00000167693 E010 343.6132274 0.0009389352 3.105770e-01 4.529894e-01 17 805068 805209 142 - 2.409 2.448 0.128
ENSG00000167693 E011 218.2091589 0.0002157827 2.877360e-02 6.955027e-02 17 805210 805247 38 - 2.182 2.257 0.250
ENSG00000167693 E012 0.3697384 0.0247485435 7.888849e-01 8.648686e-01 17 805248 805248 1 - 0.000 0.135 10.350
ENSG00000167693 E013 0.8803962 0.0136968632 8.622369e-01 9.151566e-01 17 819114 819438 325 - 0.199 0.238 0.329
ENSG00000167693 E014 316.4849411 0.0001635719 4.865357e-02 1.067753e-01 17 819439 819545 107 - 2.358 2.416 0.192
ENSG00000167693 E015 298.1984133 0.0001706006 7.083490e-01 8.060190e-01 17 822357 822457 101 - 2.381 2.381 0.000
ENSG00000167693 E016 167.7569049 0.0002043753 3.743463e-01 5.187724e-01 17 823632 823645 14 - 2.147 2.128 -0.067
ENSG00000167693 E017 217.6952297 0.0001997771 8.266595e-02 1.637219e-01 17 823646 823686 41 - 2.274 2.234 -0.134
ENSG00000167693 E018 247.2891686 0.0001940884 1.892032e-02 4.915723e-02 17 823687 823765 79 - 2.340 2.287 -0.177
ENSG00000167693 E019 0.3299976 0.0277554357 7.908121e-01   17 825566 825960 395 - 0.000 0.135 10.300
ENSG00000167693 E020 274.7577118 0.0001769176 1.107720e-07 1.116246e-06 17 825961 826078 118 - 2.438 2.317 -0.402
ENSG00000167693 E021 0.0000000       17 863887 864014 128 -      
ENSG00000167693 E022 0.5202097 0.0203675566 1.156687e-01 2.137788e-01 17 864015 864111 97 - 0.335 0.073 -2.670
ENSG00000167693 E023 0.0000000       17 896886 897014 129 -      
ENSG00000167693 E024 0.1817044 0.0390356472 1.000000e+00   17 905153 905242 90 - 0.000 0.073 9.152
ENSG00000167693 E025 0.0000000       17 907704 908034 331 -      
ENSG00000167693 E026 0.0000000       17 929663 929955 293 -      
ENSG00000167693 E027 0.0000000       17 929956 930431 476 -      
ENSG00000167693 E028 0.0000000       17 933345 933413 69 -      
ENSG00000167693 E029 11.4768500 0.0014815506 1.769133e-01 2.972345e-01 17 978299 978630 332 - 0.869 1.042 0.650
ENSG00000167693 E030 160.8667194 0.0007028735 5.021850e-06 3.573640e-05 17 979319 979393 75 - 2.223 2.081 -0.476
ENSG00000167693 E031 181.2570560 0.0114304714 3.722270e-04 1.666760e-03 17 979394 979639 246 - 2.311 2.120 -0.639
ENSG00000167693 E032 88.9941019 0.0149603697 1.040153e-01 1.966214e-01 17 979640 979776 137 - 1.936 1.837 -0.333