ENSG00000167680

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586582 ENSG00000167680 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA6B protein_coding protein_coding 2.542364 4.231516 1.35603 0.3736549 0.04686086 -1.634591 1.2677108 2.604476 0.3496831 0.2002480 0.19730661 -2.8617236 0.44812500 0.61680000 0.2530667 -0.3637333 0.29064545 0.04384016 FALSE TRUE
ENST00000586965 ENSG00000167680 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA6B protein_coding protein_coding 2.542364 4.231516 1.35603 0.3736549 0.04686086 -1.634591 0.9393713 1.221944 0.6554777 0.2191278 0.08311282 -0.8884740 0.41356667 0.28466667 0.4803333 0.1956667 0.04384016 0.04384016 FALSE TRUE
ENST00000676793 ENSG00000167680 HEK293_OSMI2_2hA HEK293_TMG_2hB SEMA6B protein_coding protein_coding 2.542364 4.231516 1.35603 0.3736549 0.04686086 -1.634591 0.2295478 0.167455 0.2572192 0.1054685 0.25721920 0.5905701 0.09641667 0.03803333 0.2015000 0.1634667 0.95566463 0.04384016 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167680 E001 31.4852941 0.0137621041 0.0049167667 0.0156984360 19 4542593 4542913 321 - 1.115 1.422 1.078
ENSG00000167680 E002 41.5111048 0.0062142430 0.0387062814 0.0886405428 19 4542914 4543096 183 - 1.350 1.527 0.609
ENSG00000167680 E003 66.6328970 0.0006194650 0.8330291865 0.8953805655 19 4543097 4544416 1320 - 1.685 1.701 0.052
ENSG00000167680 E004 23.4502898 0.0009145572 0.5458871836 0.6761558783 19 4544417 4544529 113 - 1.214 1.273 0.208
ENSG00000167680 E005 0.8407440 0.0159823523 0.0458300163 0.1017205682 19 4545790 4546215 426 - 0.478 0.120 -2.658
ENSG00000167680 E006 22.8059978 0.0099134147 0.1413175632 0.2498425973 19 4546216 4546274 59 - 1.115 1.276 0.572
ENSG00000167680 E007 20.7714117 0.0012945160 0.8466395337 0.9046796734 19 4546392 4546469 78 - 1.196 1.218 0.080
ENSG00000167680 E008 26.3645117 0.0007413622 0.2132784149 0.3424003718 19 4548027 4548173 147 - 1.387 1.291 -0.334
ENSG00000167680 E009 39.7959328 0.0007427340 0.9757440495 0.9888770880 19 4548263 4548445 183 - 1.473 1.475 0.008
ENSG00000167680 E010 33.2804865 0.0006263139 0.5470467256 0.6771361248 19 4550123 4550272 150 - 1.363 1.413 0.175
ENSG00000167680 E011 32.2484732 0.0006779708 0.2391040994 0.3730588717 19 4550799 4550930 132 - 1.309 1.408 0.343
ENSG00000167680 E012 31.5237824 0.0007464976 0.5699310004 0.6964524401 19 4552422 4552639 218 - 1.337 1.386 0.171
ENSG00000167680 E013 0.2965864 0.2768183834 1.0000000000   19 4554156 4554263 108 - 0.001 0.117 7.672
ENSG00000167680 E014 15.8178649 0.0023355425 0.3436850667 0.4877457130 19 4554388 4554476 89 - 1.177 1.083 -0.337
ENSG00000167680 E015 26.6343400 0.0007770466 0.0001755463 0.0008592359 19 4554976 4555095 120 - 1.528 1.254 -0.948
ENSG00000167680 E016 24.6916263 0.0009649688 0.0015565947 0.0058185947 19 4555474 4555564 91 - 1.473 1.231 -0.843
ENSG00000167680 E017 24.5684048 0.0009341520 0.3305052571 0.4740912353 19 4555988 4556089 102 - 1.337 1.259 -0.273
ENSG00000167680 E018 20.3268955 0.0015824384 0.5870101400 0.7104082662 19 4556951 4557013 63 - 1.231 1.184 -0.166
ENSG00000167680 E019 18.7055200 0.0153177150 0.4078026121 0.5514011723 19 4557163 4557223 61 - 1.068 1.176 0.390
ENSG00000167680 E020 17.3727859 0.0238554810 0.7377623658 0.8278458285 19 4558026 4558149 124 - 1.157 1.128 -0.103
ENSG00000167680 E021 7.8259239 0.0362919153 0.7740716042 0.8543138960 19 4558337 4558489 153 - 0.846 0.813 -0.129
ENSG00000167680 E022 0.0000000       19 4559530 4559684 155 -      
ENSG00000167680 E023 0.8878848 0.1330926606 0.3306462054 0.4742503268 19 4581463 4581776 314 - 0.369 0.171 -1.476