ENSG00000167674

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000592417 ENSG00000167674 HEK293_OSMI2_2hA HEK293_TMG_2hB HDGFL2 protein_coding protein_coding 117.5716 207.4839 67.14867 4.874473 2.412664 -1.627424 13.06941 24.35378 5.822198 0.8226145 0.5818429 -2.0626261 0.1056792 0.1176000 0.08696667 -0.03063333 0.1835742510 0.0001366875 FALSE TRUE
ENST00000616600 ENSG00000167674 HEK293_OSMI2_2hA HEK293_TMG_2hB HDGFL2 protein_coding protein_coding 117.5716 207.4839 67.14867 4.874473 2.412664 -1.627424 71.13050 122.96141 44.178203 4.6400918 2.8827737 -1.4765898 0.6039917 0.5923667 0.65706667 0.06470000 0.3066988163 0.0001366875 FALSE TRUE
ENST00000621835 ENSG00000167674 HEK293_OSMI2_2hA HEK293_TMG_2hB HDGFL2 protein_coding protein_coding 117.5716 207.4839 67.14867 4.874473 2.412664 -1.627424 10.99144 25.81613 0.753158 2.1676008 0.7531580 -5.0807058 0.0848750 0.1250000 0.01083333 -0.11416667 0.0374151834 0.0001366875 FALSE TRUE
MSTRG.16220.3 ENSG00000167674 HEK293_OSMI2_2hA HEK293_TMG_2hB HDGFL2 protein_coding   117.5716 207.4839 67.14867 4.874473 2.412664 -1.627424 14.18210 19.87714 13.370313 2.7239672 0.4214224 -0.5717239 0.1324833 0.0954000 0.20000000 0.10460000 0.0001366875 0.0001366875 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167674 E001 0.5483223 0.0210663436 6.332705e-01 7.480069e-01 19 4472231 4472232 2 + 0.209 0.128 -0.849
ENSG00000167674 E002 1.0589801 0.0984419962 5.516238e-01 6.810448e-01 19 4472233 4472237 5 + 0.349 0.228 -0.836
ENSG00000167674 E003 2.4993413 0.0059955772 3.618296e-02 8.393747e-02 19 4472238 4472245 8 + 0.726 0.375 -1.658
ENSG00000167674 E004 2.7948835 0.0055775788 2.363148e-02 5.905049e-02 19 4472246 4472247 2 + 0.774 0.405 -1.681
ENSG00000167674 E005 3.2355984 0.0049124614 6.477455e-03 1.986490e-02 19 4472248 4472251 4 + 0.856 0.433 -1.852
ENSG00000167674 E006 4.2299341 0.0036604080 4.621376e-04 2.014802e-03 19 4472252 4472254 3 + 0.985 0.485 -2.073
ENSG00000167674 E007 4.3771831 0.0037104610 1.804179e-04 8.797846e-04 19 4472255 4472255 1 + 1.012 0.485 -2.173
ENSG00000167674 E008 78.1091447 0.0184415810 2.868226e-02 6.937108e-02 19 4472256 4472296 41 + 1.924 1.750 -0.585
ENSG00000167674 E009 118.7956803 0.0098182734 1.038801e-02 2.971497e-02 19 4472297 4472305 9 + 2.091 1.934 -0.528
ENSG00000167674 E010 142.5320695 0.0091719364 1.004450e-02 2.887208e-02 19 4472306 4472307 2 + 2.165 2.015 -0.504
ENSG00000167674 E011 542.5091716 0.0028020905 1.638087e-04 8.083842e-04 19 4472308 4472422 115 + 2.721 2.601 -0.400
ENSG00000167674 E012 1.6930250 0.0110179681 4.044890e-01 5.481974e-01 19 4474892 4474911 20 + 0.209 0.375 1.151
ENSG00000167674 E013 4.3395150 0.0038648372 1.416268e-01 2.502636e-01 19 4474912 4475030 119 + 0.817 0.592 -0.934
ENSG00000167674 E014 6.5120638 0.0041833859 2.764784e-01 4.159416e-01 19 4475031 4475274 244 + 0.892 0.737 -0.608
ENSG00000167674 E015 694.5392261 0.0030222369 6.922001e-05 3.762847e-04 19 4475275 4475348 74 + 2.832 2.707 -0.415
ENSG00000167674 E016 489.1682537 0.0026024341 8.680091e-05 4.600798e-04 19 4475349 4475351 3 + 2.679 2.555 -0.414
ENSG00000167674 E017 1067.0814086 0.0005688989 1.423307e-07 1.404162e-06 19 4475445 4475583 139 + 2.993 2.900 -0.308
ENSG00000167674 E018 13.2654149 0.0013659922 3.829357e-03 1.266317e-02 19 4486383 4486385 3 + 1.277 0.988 -1.037
ENSG00000167674 E019 434.5679580 0.0006042043 2.405819e-03 8.479382e-03 19 4488676 4488679 4 + 2.591 2.516 -0.249
ENSG00000167674 E020 1366.5221858 0.0003631797 7.356072e-06 5.038271e-05 19 4488680 4488876 197 + 3.081 3.013 -0.226
ENSG00000167674 E021 1048.3655012 0.0002936138 3.676266e-03 1.222907e-02 19 4491566 4491682 117 + 2.951 2.903 -0.160
ENSG00000167674 E022 791.3299208 0.0024874300 2.744133e-01 4.135605e-01 19 4491764 4491835 72 + 2.819 2.783 -0.120
ENSG00000167674 E023 333.4472646 0.0063373046 8.717953e-01 9.215429e-01 19 4493703 4493705 3 + 2.427 2.412 -0.047
ENSG00000167674 E024 1040.9030606 0.0010527600 1.908077e-01 3.147625e-01 19 4493706 4493862 157 + 2.933 2.902 -0.100
ENSG00000167674 E025 719.0547122 0.0018183622 8.963861e-02 1.745694e-01 19 4493982 4494057 76 + 2.786 2.739 -0.156
ENSG00000167674 E026 625.7931399 0.0025433544 1.576625e-02 4.220709e-02 19 4494166 4494222 57 + 2.747 2.673 -0.248
ENSG00000167674 E027 563.0347492 0.0077448689 9.017560e-02 1.753917e-01 19 4494223 4494309 87 + 2.705 2.626 -0.263
ENSG00000167674 E028 883.1142796 0.0046359529 2.303007e-02 5.781306e-02 19 4494310 4494475 166 + 2.902 2.821 -0.270
ENSG00000167674 E029 670.4403857 0.0006711566 7.848572e-03 2.340230e-02 19 4496302 4496332 31 + 2.763 2.705 -0.194
ENSG00000167674 E030 983.4230877 0.0003216863 8.437195e-01 9.027050e-01 19 4496333 4496405 73 + 2.883 2.883 -0.002
ENSG00000167674 E031 9.0238845 0.0019316913 6.953509e-01 7.959775e-01 19 4496919 4497150 232 + 0.856 0.905 0.185
ENSG00000167674 E032 18.7147636 0.0010733143 5.143853e-01 6.491002e-01 19 4497151 4497957 807 + 1.146 1.206 0.215
ENSG00000167674 E033 1067.8515595 0.0006504371 5.748613e-01 7.005929e-01 19 4497958 4498031 74 + 2.914 2.922 0.025
ENSG00000167674 E034 937.1731783 0.0017194676 9.134604e-02 1.772353e-01 19 4498306 4498361 56 + 2.831 2.871 0.134
ENSG00000167674 E035 786.9963323 0.0018828307 1.754994e-01 2.953158e-01 19 4498362 4498376 15 + 2.760 2.795 0.115
ENSG00000167674 E036 1421.8487825 0.0013295691 9.641456e-03 2.788491e-02 19 4498814 4498915 102 + 3.001 3.054 0.176
ENSG00000167674 E037 1011.8076099 0.0014458539 3.419931e-03 1.149648e-02 19 4499491 4499529 39 + 2.843 2.909 0.220
ENSG00000167674 E038 1143.9159785 0.0014510718 7.845896e-03 2.339616e-02 19 4499530 4499588 59 + 2.902 2.961 0.195
ENSG00000167674 E039 794.9296608 0.0018408878 1.367154e-01 2.435042e-01 19 4499589 4499604 16 + 2.762 2.799 0.126
ENSG00000167674 E040 854.1707006 0.0011825971 7.009514e-03 2.124860e-02 19 4499605 4499625 21 + 2.775 2.834 0.196
ENSG00000167674 E041 763.5260206 0.0015814732 4.625558e-03 1.489011e-02 19 4499626 4499628 3 + 2.718 2.787 0.232
ENSG00000167674 E042 1226.3374809 0.0014683804 9.304504e-05 4.893427e-04 19 4499629 4499704 76 + 2.910 2.995 0.284
ENSG00000167674 E043 1368.8022343 0.0008778452 5.182640e-08 5.571015e-07 19 4501191 4501317 127 + 2.946 3.045 0.330
ENSG00000167674 E044 160.3108651 0.0013978490 1.854956e-02 4.834003e-02 19 4501318 4501461 144 + 2.021 2.113 0.310
ENSG00000167674 E045 179.0467850 0.0002159582 1.455549e-01 2.556194e-01 19 4501462 4501668 207 + 2.110 2.156 0.152
ENSG00000167674 E046 197.2844560 0.0089880318 5.119360e-02 1.112785e-01 19 4501669 4501910 242 + 2.100 2.208 0.361
ENSG00000167674 E047 466.4936533 0.0002198550 4.430319e-05 2.528349e-04 19 4501911 4501913 3 + 2.490 2.577 0.290
ENSG00000167674 E048 1195.6156516 0.0001855201 2.169539e-17 1.013095e-15 19 4501914 4502208 295 + 2.868 2.990 0.404
ENSG00000167674 E049 0.0000000       19 4527350 4527466 117 +