ENSG00000167670

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301280 ENSG00000167670 HEK293_OSMI2_2hA HEK293_TMG_2hB CHAF1A protein_coding protein_coding 60.64634 81.71819 50.17255 1.190195 2.231591 -0.7036479 46.937719 57.6401225 41.9346639 4.1940367 0.84371271 -0.4588364 0.78252500 0.70476667 0.837766667 0.13300000 1.067859e-01 1.102579e-12 FALSE  
ENST00000585854 ENSG00000167670 HEK293_OSMI2_2hA HEK293_TMG_2hB CHAF1A protein_coding protein_coding 60.64634 81.71819 50.17255 1.190195 2.231591 -0.7036479 1.982547 0.9128532 3.3836266 0.2910369 1.78490742 1.8786548 0.03716667 0.01106667 0.064800000 0.05373333 7.513172e-01 1.102579e-12 FALSE  
MSTRG.16212.1 ENSG00000167670 HEK293_OSMI2_2hA HEK293_TMG_2hB CHAF1A protein_coding   60.64634 81.71819 50.17255 1.190195 2.231591 -0.7036479 3.080783 6.7327145 1.5535562 0.8897369 0.08170942 -2.1084985 0.04495417 0.08213333 0.031033333 -0.05110000 9.785004e-06 1.102579e-12 FALSE  
MSTRG.16212.15 ENSG00000167670 HEK293_OSMI2_2hA HEK293_TMG_2hB CHAF1A protein_coding   60.64634 81.71819 50.17255 1.190195 2.231591 -0.7036479 2.336149 7.8367763 0.3227705 2.2111103 0.06785832 -4.5595006 0.03219583 0.09616667 0.006533333 -0.08963333 2.426572e-07 1.102579e-12 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167670 E001 4.2868318 4.048316e-03 3.427786e-05 2.009356e-04 19 4402637 4402639 3 + 1.004 0.420 -2.482
ENSG00000167670 E002 63.7192458 3.184779e-02 3.888885e-04 1.731748e-03 19 4402640 4402701 62 + 1.981 1.635 -1.167
ENSG00000167670 E003 82.6654995 3.371708e-02 9.290574e-04 3.715896e-03 19 4402702 4402716 15 + 2.080 1.759 -1.079
ENSG00000167670 E004 171.6288685 8.586659e-03 3.726283e-07 3.381877e-06 19 4402717 4402814 98 + 2.370 2.095 -0.919
ENSG00000167670 E005 168.1413429 9.003582e-03 5.356393e-06 3.786390e-05 19 4405912 4405962 51 + 2.349 2.097 -0.843
ENSG00000167670 E006 1.4006073 1.512805e-02 2.006808e-01 3.270510e-01 19 4408878 4408902 25 + 0.515 0.285 -1.292
ENSG00000167670 E007 1107.9376513 8.893757e-04 2.422101e-20 1.611165e-18 19 4408903 4409444 542 + 3.114 2.949 -0.550
ENSG00000167670 E008 840.1910016 3.557109e-04 2.298024e-11 4.512840e-10 19 4409445 4409759 315 + 2.959 2.850 -0.362
ENSG00000167670 E009 5.9314959 2.776906e-03 6.072423e-03 1.880147e-02 19 4410412 4410523 112 + 1.024 0.674 -1.360
ENSG00000167670 E010 224.2784080 1.402720e-03 4.702083e-04 2.046113e-03 19 4418020 4418028 9 + 2.389 2.274 -0.385
ENSG00000167670 E011 336.4351423 4.568899e-04 2.783410e-07 2.592854e-06 19 4418029 4418076 48 + 2.570 2.448 -0.408
ENSG00000167670 E012 0.8512514 1.369686e-02 4.886277e-01 6.261732e-01 19 4418077 4418132 56 + 0.163 0.286 1.031
ENSG00000167670 E013 669.1817773 2.159622e-04 7.581717e-04 3.108752e-03 19 4422566 4422795 230 + 2.828 2.767 -0.203
ENSG00000167670 E014 324.2604130 1.850329e-04 1.437546e-02 3.907915e-02 19 4423335 4423395 61 + 2.441 2.486 0.150
ENSG00000167670 E015 366.0722195 1.426701e-04 6.461351e-04 2.702231e-03 19 4423806 4423874 69 + 2.482 2.543 0.204
ENSG00000167670 E016 595.2358943 1.581986e-03 1.224002e-01 2.233709e-01 19 4428664 4428890 227 + 2.715 2.743 0.096
ENSG00000167670 E017 0.9921577 1.264822e-02 9.614906e-01 9.797464e-01 19 4429038 4429437 400 + 0.281 0.286 0.032
ENSG00000167670 E018 663.0470805 7.979867e-04 7.727419e-01 8.533061e-01 19 4429438 4429606 169 + 2.791 2.777 -0.046
ENSG00000167670 E019 299.5538184 8.178445e-03 8.953869e-01 9.371836e-01 19 4429708 4429710 3 + 2.440 2.438 -0.007
ENSG00000167670 E020 575.5539569 1.805441e-03 9.686935e-01 9.843946e-01 19 4429711 4429788 78 + 2.727 2.720 -0.025
ENSG00000167670 E021 688.0494418 1.761254e-04 5.271773e-01 6.603117e-01 19 4430549 4430641 93 + 2.798 2.799 0.004
ENSG00000167670 E022 0.3729606 3.064731e-02 6.372688e-01 7.511972e-01 19 4431055 4431114 60 + 0.163 0.091 -0.965
ENSG00000167670 E023 375.3518191 1.768847e-04 1.802731e-01 3.015167e-01 19 4431952 4431954 3 + 2.523 2.542 0.062
ENSG00000167670 E024 902.8145004 9.588684e-05 1.185610e-08 1.441842e-07 19 4431955 4432207 253 + 2.869 2.935 0.220
ENSG00000167670 E025 1158.9865353 3.588073e-04 4.860504e-14 1.444631e-12 19 4433070 4433539 470 + 2.955 3.052 0.322
ENSG00000167670 E026 12.7670372 1.411354e-03 6.480793e-01 7.596533e-01 19 4439921 4440021 101 + 1.138 1.085 -0.190
ENSG00000167670 E027 339.8978402 1.166783e-03 1.418963e-02 3.865497e-02 19 4442245 4442253 9 + 2.453 2.510 0.192
ENSG00000167670 E028 607.9638473 1.298518e-03 3.827123e-07 3.462988e-06 19 4442254 4442341 88 + 2.665 2.776 0.368
ENSG00000167670 E029 265.3719350 7.664682e-04 2.803789e-13 7.483368e-12 19 4442925 4442926 2 + 2.240 2.437 0.656
ENSG00000167670 E030 866.3889028 1.198809e-03 7.969204e-18 3.964658e-16 19 4442927 4443397 471 + 2.771 2.944 0.575
ENSG00000167670 E031 24.0860823 1.268212e-02 2.710261e-05 1.629434e-04 19 4444544 4445018 475 + 1.588 1.214 -1.297