ENSG00000167657

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301264 ENSG00000167657 HEK293_OSMI2_2hA HEK293_TMG_2hB DAPK3 protein_coding protein_coding 64.95582 111.5589 38.37155 10.49154 1.481811 -1.53945 4.463580 14.676357 0.000000 2.2253084 0.0000000 -10.5202609 0.05535833 0.13786667 0.00000000 -0.137866667 1.557470e-18 1.55747e-18 FALSE TRUE
ENST00000595279 ENSG00000167657 HEK293_OSMI2_2hA HEK293_TMG_2hB DAPK3 protein_coding retained_intron 64.95582 111.5589 38.37155 10.49154 1.481811 -1.53945 3.876993 5.612985 2.043285 0.2831602 0.1392169 -1.4534022 0.05937917 0.05093333 0.05346667 0.002533333 9.289642e-01 1.55747e-18 FALSE TRUE
ENST00000596311 ENSG00000167657 HEK293_OSMI2_2hA HEK293_TMG_2hB DAPK3 protein_coding protein_coding 64.95582 111.5589 38.37155 10.49154 1.481811 -1.53945 10.438720 15.675519 9.825792 4.7510504 1.9821033 -0.6733201 0.18598333 0.13503333 0.25493333 0.119900000 1.768613e-01 1.55747e-18 FALSE FALSE
MSTRG.16187.2 ENSG00000167657 HEK293_OSMI2_2hA HEK293_TMG_2hB DAPK3 protein_coding   64.95582 111.5589 38.37155 10.49154 1.481811 -1.53945 40.113296 66.793405 21.773649 6.9810028 1.0065142 -1.6166760 0.59697500 0.59770000 0.56900000 -0.028700000 8.052193e-01 1.55747e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167657 E001 1.8004460 9.872448e-03 7.996708e-01 8.722300e-01 19 3958453 3958453 1 - 0.353 0.401 0.273
ENSG00000167657 E002 5.7452384 2.938506e-03 6.176815e-02 1.295980e-01 19 3958454 3958457 4 - 0.460 0.783 1.427
ENSG00000167657 E003 8.6486716 1.953298e-03 1.887139e-01 3.121183e-01 19 3958458 3958463 6 - 0.732 0.917 0.724
ENSG00000167657 E004 158.0481022 9.373748e-03 8.066475e-04 3.282433e-03 19 3958464 3958646 183 - 1.917 2.121 0.686
ENSG00000167657 E005 357.2158771 1.270040e-02 2.823097e-02 6.847103e-02 19 3958647 3958722 76 - 2.330 2.464 0.447
ENSG00000167657 E006 1645.2235109 7.689325e-05 3.217559e-22 2.622878e-20 19 3958723 3959637 915 - 3.014 3.117 0.341
ENSG00000167657 E007 25.1864241 7.226383e-03 3.204985e-01 4.636409e-01 19 3959639 3960058 420 - 1.384 1.294 -0.313
ENSG00000167657 E008 419.6745228 1.492651e-04 1.111860e-01 2.072907e-01 19 3960059 3960104 46 - 2.482 2.514 0.107
ENSG00000167657 E009 717.8536727 1.045780e-04 2.882204e-01 4.287795e-01 19 3961009 3961161 153 - 2.728 2.743 0.049
ENSG00000167657 E010 68.5243069 3.821457e-04 2.274285e-03 8.072403e-03 19 3961162 3961413 252 - 1.849 1.694 -0.524
ENSG00000167657 E011 71.9280712 3.870400e-04 1.247613e-05 8.109120e-05 19 3961414 3961840 427 - 1.910 1.699 -0.714
ENSG00000167657 E012 368.8241061 2.828571e-04 1.873873e-01 3.104473e-01 19 3963643 3963669 27 - 2.479 2.445 -0.112
ENSG00000167657 E013 492.9741399 1.711478e-04 5.145285e-04 2.213701e-03 19 3963871 3963919 49 - 2.635 2.564 -0.236
ENSG00000167657 E014 636.7116354 1.180586e-04 2.348185e-02 5.874479e-02 19 3964244 3964321 78 - 2.723 2.681 -0.139
ENSG00000167657 E015 368.7434797 1.524046e-04 2.724320e-02 6.648386e-02 19 3964322 3964322 1 - 2.495 2.442 -0.177
ENSG00000167657 E016 558.5545112 1.251721e-04 4.159480e-02 9.399091e-02 19 3964323 3964373 51 - 2.665 2.624 -0.135
ENSG00000167657 E017 1174.5506417 1.688802e-03 4.483502e-02 9.989839e-02 19 3964631 3964991 361 - 2.988 2.948 -0.133
ENSG00000167657 E018 488.1161702 4.524809e-03 6.819009e-02 1.403687e-01 19 3969674 3969829 156 - 2.627 2.563 -0.214
ENSG00000167657 E019 1.6972939 8.515251e-03 4.854513e-02 1.065867e-01 19 3969830 3969938 109 - 0.617 0.266 -1.893
ENSG00000167657 E020 0.1817044 3.933649e-02 1.000000e+00   19 3970594 3970624 31 - 0.001 0.068 6.767
ENSG00000167657 E021 17.4900307 1.032891e-03 2.273792e-02 5.720929e-02 19 3970921 3971021 101 - 1.324 1.113 -0.745
ENSG00000167657 E022 179.0980903 8.097200e-03 8.620951e-03 2.533960e-02 19 3971022 3971123 102 - 2.250 2.112 -0.461