ENSG00000167645

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000329420 ENSG00000167645 HEK293_OSMI2_2hA HEK293_TMG_2hB YIF1B protein_coding protein_coding 120.9345 206.0868 75.70444 8.696877 2.657963 -1.444681 23.47387 38.20977 17.491550 1.1842842 1.5323781 -1.1268363 0.19910417 0.1857333 0.23036667 0.044633333 1.500431e-01 4.292363e-08 FALSE TRUE
ENST00000589247 ENSG00000167645 HEK293_OSMI2_2hA HEK293_TMG_2hB YIF1B protein_coding protein_coding 120.9345 206.0868 75.70444 8.696877 2.657963 -1.444681 12.17816 20.17647 10.691953 1.4586188 0.9496762 -0.9155142 0.10567917 0.0980000 0.14093333 0.042933333 3.888005e-02 4.292363e-08 FALSE FALSE
ENST00000591784 ENSG00000167645 HEK293_OSMI2_2hA HEK293_TMG_2hB YIF1B protein_coding protein_coding 120.9345 206.0868 75.70444 8.696877 2.657963 -1.444681 16.53974 21.75098 11.850543 0.7252285 0.8953880 -0.8755732 0.14660417 0.1057000 0.15726667 0.051566667 3.155878e-02 4.292363e-08 FALSE TRUE
ENST00000592694 ENSG00000167645 HEK293_OSMI2_2hA HEK293_TMG_2hB YIF1B protein_coding protein_coding 120.9345 206.0868 75.70444 8.696877 2.657963 -1.444681 53.19973 99.98311 25.323970 4.2542336 1.6628155 -1.9807556 0.42075000 0.4854333 0.33386667 -0.151566667 4.292363e-08 4.292363e-08 FALSE TRUE
MSTRG.17090.10 ENSG00000167645 HEK293_OSMI2_2hA HEK293_TMG_2hB YIF1B protein_coding   120.9345 206.0868 75.70444 8.696877 2.657963 -1.444681 7.83546 14.05511 4.780734 1.8425219 0.3375220 -1.5538023 0.06170417 0.0677000 0.06356667 -0.004133333 9.139705e-01 4.292363e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167645 E001 22.672525 2.858504e-02 1.735011e-01 2.927463e-01 19 38303558 38305103 1546 - 1.399 1.238 -0.564
ENSG00000167645 E002 2.385389 6.585636e-03 6.250390e-01 7.412307e-01 19 38305104 38305113 10 - 0.533 0.440 -0.457
ENSG00000167645 E003 3.960235 5.831722e-03 5.241972e-01 6.578186e-01 19 38305114 38305114 1 - 0.533 0.637 0.468
ENSG00000167645 E004 4.996298 3.360138e-03 2.229292e-01 3.538695e-01 19 38305115 38305115 1 - 0.533 0.732 0.864
ENSG00000167645 E005 65.059975 4.230145e-03 2.799636e-02 6.800475e-02 19 38305116 38305197 82 - 1.611 1.746 0.460
ENSG00000167645 E006 497.437888 3.090046e-04 8.041260e-15 2.683446e-13 19 38305198 38305351 154 - 2.454 2.620 0.554
ENSG00000167645 E007 338.706677 1.912028e-04 1.854987e-08 2.176659e-07 19 38305352 38305361 10 - 2.313 2.449 0.455
ENSG00000167645 E008 847.934780 1.167373e-04 3.719241e-10 5.962588e-09 19 38305362 38305507 146 - 2.750 2.841 0.303
ENSG00000167645 E009 2.174538 6.680583e-03 5.973703e-01 7.191540e-01 19 38306697 38306761 65 - 0.344 0.441 0.544
ENSG00000167645 E010 5.952026 3.778371e-03 6.966456e-01 7.969314e-01 19 38306762 38306881 120 - 0.808 0.746 -0.249
ENSG00000167645 E011 17.803715 1.425334e-03 2.907888e-01 4.315905e-01 19 38306882 38306913 32 - 1.252 1.146 -0.376
ENSG00000167645 E012 45.898516 9.109475e-03 7.032478e-01 8.019562e-01 19 38306914 38306990 77 - 1.598 1.562 -0.121
ENSG00000167645 E013 6.245119 3.134964e-03 2.420516e-03 8.523568e-03 19 38306991 38307427 437 - 1.051 0.655 -1.544
ENSG00000167645 E014 752.847568 3.328999e-04 3.028453e-04 1.391100e-03 19 38307428 38307470 43 - 2.727 2.784 0.191
ENSG00000167645 E015 920.940845 9.220096e-05 1.263587e-01 2.290766e-01 19 38307471 38307521 51 - 2.849 2.863 0.048
ENSG00000167645 E016 29.801777 6.673232e-04 8.439079e-02 1.664333e-01 19 38307522 38307596 75 - 1.493 1.361 -0.458
ENSG00000167645 E017 1455.839725 3.594580e-04 4.249393e-01 5.678897e-01 19 38307597 38307752 156 - 3.057 3.062 0.014
ENSG00000167645 E018 2.760440 6.109288e-03 9.754429e-02 1.867425e-01 19 38307753 38307774 22 - 0.718 0.440 -1.266
ENSG00000167645 E019 683.885937 3.077735e-04 3.870709e-01 5.312225e-01 19 38308792 38308810 19 - 2.726 2.735 0.028
ENSG00000167645 E020 807.496045 5.199212e-04 2.102229e-01 3.388128e-01 19 38308811 38308849 39 - 2.828 2.799 -0.097
ENSG00000167645 E021 3.747385 7.339235e-03 5.572065e-01 6.856754e-01 19 38308850 38308978 129 - 0.664 0.561 -0.454
ENSG00000167645 E022 1085.580125 1.250111e-03 9.024655e-02 1.755098e-01 19 38308979 38309057 79 - 2.965 2.925 -0.133
ENSG00000167645 E023 8.869279 1.940525e-03 1.964221e-01 3.217546e-01 19 38309058 38309223 166 - 1.027 0.865 -0.609
ENSG00000167645 E024 1202.801623 1.019286e-04 8.393780e-04 3.399556e-03 19 38309224 38309328 105 - 3.015 2.967 -0.161
ENSG00000167645 E025 8.589601 4.756818e-03 7.370980e-01 8.273649e-01 19 38309329 38309404 76 - 0.847 0.886 0.150
ENSG00000167645 E026 1490.466228 5.876718e-04 2.660001e-06 2.014508e-05 19 38309405 38309643 239 - 3.128 3.055 -0.245
ENSG00000167645 E027 2.306950 6.436122e-02 1.771419e-01 2.975141e-01 19 38309644 38309923 280 - 0.205 0.493 1.809
ENSG00000167645 E028 17.171771 1.048582e-03 3.138903e-01 4.565299e-01 19 38315425 38315716 292 - 1.238 1.135 -0.364
ENSG00000167645 E029 111.823123 3.651202e-04 1.096806e-03 4.293408e-03 19 38315717 38315722 6 - 2.054 1.918 -0.454
ENSG00000167645 E030 170.822099 2.462451e-03 2.452241e-03 8.620704e-03 19 38315723 38315746 24 - 2.230 2.105 -0.420
ENSG00000167645 E031 187.653236 2.265570e-03 1.367002e-05 8.798620e-05 19 38315747 38315859 113 - 2.301 2.133 -0.561
ENSG00000167645 E032 73.978847 9.990089e-03 9.780866e-01 9.904352e-01 19 38315860 38315868 9 - 1.770 1.769 -0.004
ENSG00000167645 E033 352.992087 4.175268e-03 7.475246e-01 8.350017e-01 19 38315869 38315992 124 - 2.438 2.446 0.027
ENSG00000167645 E034 0.000000       19 38317152 38317273 122 -