ENSG00000167632

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000438773 ENSG00000167632 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC9 protein_coding protein_coding 7.026083 10.58813 4.495819 0.6001635 0.05660021 -1.233948 0.7709446 1.1660487 0.4044627 0.06530941 0.09232817 -1.504634 0.10776250 0.1101333 0.08996667 -0.02016667 7.190782e-01 3.451137e-08 FALSE TRUE
ENST00000520857 ENSG00000167632 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC9 protein_coding protein_coding 7.026083 10.58813 4.495819 0.6001635 0.05660021 -1.233948 0.1216205 0.9729639 0.0000000 0.97296392 0.00000000 -6.619067 0.01285417 0.1028333 0.00000000 -0.10283333 9.208247e-01 3.451137e-08 FALSE TRUE
MSTRG.32137.3 ENSG00000167632 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC9 protein_coding   7.026083 10.58813 4.495819 0.6001635 0.05660021 -1.233948 0.3204557 0.0000000 0.6438058 0.00000000 0.22459931 6.030790 0.06626667 0.0000000 0.14346667 0.14346667 3.451137e-08 3.451137e-08 TRUE TRUE
MSTRG.32137.4 ENSG00000167632 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC9 protein_coding   7.026083 10.58813 4.495819 0.6001635 0.05660021 -1.233948 5.5920874 8.1570333 3.4030547 1.60063855 0.30104780 -1.258749 0.78162083 0.7579333 0.75653333 -0.00140000 9.475836e-01 3.451137e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167632 E001 12.3723705 0.0093002826 1.360046e-01 2.424821e-01 8 139727725 139728445 721 - 0.886 1.075 0.700
ENSG00000167632 E002 5.4980214 0.0517747780 9.460196e-01 9.701063e-01 8 139728446 139728472 27 - 0.737 0.734 -0.015
ENSG00000167632 E003 50.0900610 0.0120643839 9.956489e-01 1.000000e+00 8 139728473 139730344 1872 - 1.626 1.626 -0.001
ENSG00000167632 E004 97.6974420 0.0064781269 2.611894e-04 1.221418e-03 8 139730345 139730657 313 - 1.732 1.954 0.746
ENSG00000167632 E005 103.5182473 0.0057285718 2.252880e-04 1.071611e-03 8 139730658 139730818 161 - 1.763 1.976 0.720
ENSG00000167632 E006 63.6155676 0.0049196028 4.542541e-02 1.009752e-01 8 139730819 139730891 73 - 1.626 1.755 0.438
ENSG00000167632 E007 60.2402996 0.0191140692 9.589778e-03 2.775774e-02 8 139730892 139730995 104 - 1.508 1.747 0.814
ENSG00000167632 E008 32.5615309 0.0371022476 4.028869e-02 9.156816e-02 8 139730996 139731005 10 - 1.234 1.492 0.895
ENSG00000167632 E009 35.3274415 0.0252047456 3.597801e-02 8.353874e-02 8 139731006 139731022 17 - 1.288 1.521 0.807
ENSG00000167632 E010 34.0249450 0.0058961657 2.521888e-03 8.828247e-03 8 139731023 139731043 21 - 1.249 1.509 0.904
ENSG00000167632 E011 86.1319529 0.0099098172 4.010494e-03 1.317226e-02 8 139731044 139731228 185 - 1.695 1.894 0.674
ENSG00000167632 E012 59.5792688 0.0184891804 1.060371e-01 1.996650e-01 8 139731979 139732092 114 - 1.590 1.729 0.470
ENSG00000167632 E013 48.3002238 0.0004750834 3.514584e-01 4.956913e-01 8 139732093 139732161 69 - 1.565 1.621 0.193
ENSG00000167632 E014 43.1666434 0.0005621327 3.522522e-01 4.965225e-01 8 139732162 139732202 41 - 1.516 1.576 0.204
ENSG00000167632 E015 0.1515154 0.0433915121 1.585986e-01   8 139806133 139806233 101 - 0.193 0.000 -13.317
ENSG00000167632 E016 0.0000000       8 139881088 139881295 208 -      
ENSG00000167632 E017 56.6185458 0.0097371712 8.224124e-02 1.630427e-01 8 139885879 139885969 91 - 1.572 1.705 0.454
ENSG00000167632 E018 0.7426990 0.0309909550 1.000000e+00 1.000000e+00 8 139904432 139904910 479 - 0.193 0.196 0.033
ENSG00000167632 E019 0.1472490 0.0431939975 1.588139e-01   8 139908617 139908758 142 - 0.193 0.000 -13.317
ENSG00000167632 E020 88.9460207 0.0025484523 3.677772e-02 8.504434e-02 8 139910147 139910300 154 - 1.787 1.895 0.364
ENSG00000167632 E021 46.7114514 0.0017638084 5.830431e-01 7.072427e-01 8 139988726 139988739 14 - 1.571 1.607 0.122
ENSG00000167632 E022 71.7660009 0.0004095201 3.845501e-01 5.286859e-01 8 139988740 139988822 83 - 1.746 1.789 0.147
ENSG00000167632 E023 42.3886911 0.0005270009 2.571023e-01 3.941444e-01 8 139988823 139988836 14 - 1.493 1.567 0.253
ENSG00000167632 E024 0.0000000       8 140008467 140008591 125 -      
ENSG00000167632 E025 93.5588814 0.0003044826 6.969559e-01 7.972093e-01 8 140023937 140024079 143 - 1.876 1.894 0.059
ENSG00000167632 E026 0.3697384 0.0249840593 6.991550e-01 7.989722e-01 8 140081989 140082153 165 - 0.000 0.140 10.932
ENSG00000167632 E027 0.0000000       8 140215910 140216054 145 -      
ENSG00000167632 E028 79.8134998 0.0003874528 6.040167e-01 7.246707e-01 8 140221459 140221583 125 - 1.807 1.831 0.084
ENSG00000167632 E029 0.0000000       8 140238341 140238493 153 -      
ENSG00000167632 E030 0.1482932 0.0421078137 1.000000e+00   8 140252571 140252776 206 - 0.000 0.075 9.928
ENSG00000167632 E031 82.4634470 0.0003747942 5.744311e-02 1.222497e-01 8 140252777 140252929 153 - 1.763 1.853 0.304
ENSG00000167632 E032 0.0000000       8 140262607 140262731 125 -      
ENSG00000167632 E033 78.8301697 0.0051286982 4.115790e-01 5.551254e-01 8 140275658 140275821 164 - 1.775 1.827 0.174
ENSG00000167632 E034 53.6194765 0.0016024469 9.153989e-01 9.504685e-01 8 140283889 140283986 98 - 1.654 1.649 -0.016
ENSG00000167632 E035 36.3066988 0.0021947989 6.296127e-01 7.449582e-01 8 140283987 140284021 35 - 1.508 1.476 -0.111
ENSG00000167632 E036 68.4799089 0.0101512497 8.851035e-01 9.305590e-01 8 140287608 140287734 127 - 1.741 1.758 0.058
ENSG00000167632 E037 63.5271499 0.0025237028 1.925736e-01 3.169911e-01 8 140290993 140291078 86 - 1.775 1.706 -0.234
ENSG00000167632 E038 0.1451727 0.0431592503 1.589005e-01   8 140291079 140291251 173 - 0.193 0.000 -13.317
ENSG00000167632 E039 81.4118068 0.0004893980 2.207924e-01 3.513815e-01 8 140300469 140300614 146 - 1.870 1.816 -0.182
ENSG00000167632 E040 0.0000000       8 140302685 140302835 151 -      
ENSG00000167632 E041 67.6164252 0.0007310892 2.149886e-03 7.689930e-03 8 140311248 140311374 127 - 1.860 1.714 -0.493
ENSG00000167632 E042 59.5427458 0.0085323482 4.899898e-03 1.565091e-02 8 140360050 140360193 144 - 1.832 1.654 -0.603
ENSG00000167632 E043 60.9053933 0.0135751124 2.786838e-02 6.775555e-02 8 140370964 140371180 217 - 1.828 1.670 -0.537
ENSG00000167632 E044 51.5660544 0.0044103146 8.676591e-03 2.547522e-02 8 140397620 140397745 126 - 1.754 1.597 -0.535
ENSG00000167632 E045 0.1817044 0.0398131293 1.000000e+00   8 140405293 140405576 284 - 0.000 0.076 9.932
ENSG00000167632 E046 53.6071733 0.0045163973 2.855419e-05 1.707115e-04 8 140405577 140405698 122 - 1.832 1.588 -0.829
ENSG00000167632 E047 9.5960607 0.0018202977 3.011284e-02 7.218416e-02 8 140426615 140426641 27 - 1.123 0.883 -0.885
ENSG00000167632 E048 35.3839718 0.0055993948 6.402296e-07 5.542893e-06 8 140435112 140435240 129 - 1.719 1.377 -1.168
ENSG00000167632 E049 35.3103619 0.0236033160 7.056187e-03 2.137094e-02 8 140439052 140439197 146 - 1.660 1.413 -0.844
ENSG00000167632 E050 131.3523911 0.0023219367 2.639369e-12 6.048391e-11 8 140450790 140451383 594 - 2.228 1.962 -0.891
ENSG00000167632 E051 34.8282722 0.0437202373 6.175871e-02 1.295825e-01 8 140457639 140457744 106 - 1.615 1.418 -0.673
ENSG00000167632 E052 0.2214452 0.0391382085 1.000000e+00   8 140458281 140458579 299 - 0.000 0.076 9.935