ENSG00000167615

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376514 ENSG00000167615 HEK293_OSMI2_2hA HEK293_TMG_2hB LENG8 protein_coding protein_coding 82.37861 72.51684 73.57025 8.344784 2.680003 0.02080368 17.021395 12.002523 14.061946 1.4397819 0.5584152 0.2282826 0.1979958 0.16560000 0.1911000 0.02550000 1.915298e-01 7.877234e-10 FALSE TRUE
ENST00000421200 ENSG00000167615 HEK293_OSMI2_2hA HEK293_TMG_2hB LENG8 protein_coding protein_coding 82.37861 72.51684 73.57025 8.344784 2.680003 0.02080368 27.313282 31.686506 19.907016 3.4955362 0.5538011 -0.6703223 0.3264292 0.43866667 0.2709333 -0.16773333 4.973093e-07 7.877234e-10 FALSE FALSE
ENST00000439657 ENSG00000167615 HEK293_OSMI2_2hA HEK293_TMG_2hB LENG8 protein_coding protein_coding 82.37861 72.51684 73.57025 8.344784 2.680003 0.02080368 8.286231 1.947847 11.771619 0.9749588 1.3097451 2.5891978 0.1081125 0.02473333 0.1595667 0.13483333 2.323407e-01 7.877234e-10 FALSE TRUE
MSTRG.17688.14 ENSG00000167615 HEK293_OSMI2_2hA HEK293_TMG_2hB LENG8 protein_coding   82.37861 72.51684 73.57025 8.344784 2.680003 0.02080368 8.203699 2.614000 9.627293 0.4908661 0.4780744 1.8768601 0.0997750 0.03673333 0.1308667 0.09413333 4.753783e-06 7.877234e-10 TRUE TRUE
MSTRG.17688.7 ENSG00000167615 HEK293_OSMI2_2hA HEK293_TMG_2hB LENG8 protein_coding   82.37861 72.51684 73.57025 8.344784 2.680003 0.02080368 7.919605 11.880468 6.146357 1.6794872 0.7016658 -0.9496567 0.1035542 0.16353333 0.0844000 -0.07913333 1.297551e-02 7.877234e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167615 E001 1.4371390 0.0093654680 7.289723e-01 8.213002e-01 19 54448492 54448738 247 + 0.361 0.420 0.329
ENSG00000167615 E002 0.4417591 0.2016716488 6.198418e-01 7.371355e-01 19 54448739 54448784 46 + 0.122 0.215 0.978
ENSG00000167615 E003 0.2934659 0.0298871273 9.939106e-01   19 54448785 54448787 3 + 0.122 0.122 0.005
ENSG00000167615 E004 0.4815130 0.0209323442 5.595907e-01 6.876802e-01 19 54448788 54448886 99 + 0.122 0.218 1.005
ENSG00000167615 E005 5.1447831 0.0031346125 6.415464e-02 1.336196e-01 19 54448887 54449189 303 + 0.628 0.877 1.009
ENSG00000167615 E006 7.9671945 0.0020493763 3.470408e-01 4.912124e-01 19 54449190 54449198 9 + 1.004 0.895 -0.407
ENSG00000167615 E007 28.0681504 0.0024703163 1.194905e-04 6.115592e-04 19 54449199 54449215 17 + 1.583 1.314 -0.928
ENSG00000167615 E008 31.8776349 0.0008710078 2.275807e-06 1.748570e-05 19 54449216 54449216 1 + 1.648 1.347 -1.035
ENSG00000167615 E009 67.8932930 0.0051853168 3.535170e-05 2.064575e-04 19 54449217 54449223 7 + 1.941 1.711 -0.777
ENSG00000167615 E010 88.2338456 0.0117750571 1.725354e-03 6.362546e-03 19 54449224 54449227 4 + 2.042 1.841 -0.673
ENSG00000167615 E011 201.1393815 0.0047030707 1.290786e-05 8.355904e-05 19 54449228 54449306 79 + 2.387 2.209 -0.593
ENSG00000167615 E012 66.1339783 0.0060323919 3.520953e-03 1.178735e-02 19 54449307 54449310 4 + 1.902 1.736 -0.563
ENSG00000167615 E013 3.5303093 0.0153058955 8.134790e-01 8.817387e-01 19 54449612 54449744 133 + 0.628 0.663 0.149
ENSG00000167615 E014 240.7193588 0.0015879849 1.931425e-07 1.856149e-06 19 54451290 54451382 93 + 2.453 2.299 -0.516
ENSG00000167615 E015 1.7391137 0.0144289082 3.406564e-02 7.988852e-02 19 54451992 54452092 101 + 0.593 0.218 -2.160
ENSG00000167615 E016 324.6336824 0.0032033325 3.358864e-03 1.131771e-02 19 54452093 54452267 175 + 2.556 2.462 -0.314
ENSG00000167615 E017 219.7616496 0.0025553592 1.109663e-01 2.069646e-01 19 54452651 54452752 102 + 2.364 2.312 -0.173
ENSG00000167615 E018 146.4134341 0.0042264195 1.545110e-02 4.151535e-02 19 54453546 54453656 111 + 2.216 2.113 -0.345
ENSG00000167615 E019 398.9532039 0.0039665197 1.692744e-01 2.872443e-01 19 54454430 54454682 253 + 2.622 2.577 -0.150
ENSG00000167615 E020 358.8473517 0.0009324901 6.343301e-02 1.324092e-01 19 54454951 54455092 142 + 2.575 2.530 -0.150
ENSG00000167615 E021 383.3219931 0.0005813382 1.621496e-01 2.779189e-01 19 54455364 54455567 204 + 2.595 2.564 -0.104
ENSG00000167615 E022 418.6352556 0.0014198507 6.343688e-03 1.951786e-02 19 54455967 54456245 279 + 2.577 2.646 0.229
ENSG00000167615 E023 334.9055701 0.0006797565 1.771932e-05 1.111952e-04 19 54456325 54456465 141 + 2.462 2.559 0.325
ENSG00000167615 E024 460.0312668 0.0002460329 4.774205e-04 2.073543e-03 19 54456636 54456921 286 + 2.621 2.681 0.201
ENSG00000167615 E025 337.4742945 0.0001554439 5.762940e-01 7.017700e-01 19 54457747 54457848 102 + 2.517 2.525 0.028
ENSG00000167615 E026 314.2682510 0.0001468734 1.051281e-02 3.000873e-02 19 54457934 54458002 69 + 2.463 2.513 0.166
ENSG00000167615 E027 462.7789856 0.0001323863 9.457050e-04 3.773876e-03 19 54458103 54458232 130 + 2.628 2.682 0.179
ENSG00000167615 E028 424.5771532 0.0001211060 2.540452e-03 8.884742e-03 19 54458314 54458414 101 + 2.593 2.644 0.168
ENSG00000167615 E029 424.2638756 0.0001468344 9.378649e-06 6.274967e-05 19 54458415 54458521 107 + 2.577 2.654 0.255
ENSG00000167615 E030 128.8369541 0.0002427458 1.387919e-12 3.321591e-11 19 54458522 54458567 46 + 2.216 1.988 -0.764
ENSG00000167615 E031 760.6941123 0.0007154790 4.165298e-25 4.598503e-23 19 54458568 54459352 785 + 2.966 2.785 -0.600
ENSG00000167615 E032 111.8374088 0.0096291543 1.291083e-01 2.329386e-01 19 54459353 54459408 56 + 2.098 2.008 -0.302
ENSG00000167615 E033 91.3982045 0.0014663152 1.246232e-04 6.349537e-04 19 54459409 54459464 56 + 2.043 1.883 -0.536
ENSG00000167615 E034 73.9695691 0.0110819558 2.734831e-02 6.670257e-02 19 54459465 54459481 17 + 1.948 1.803 -0.486
ENSG00000167615 E035 120.5916197 0.0025964100 4.724002e-05 2.677801e-04 19 54459482 54459537 56 + 2.166 1.999 -0.556
ENSG00000167615 E036 98.8190636 0.0012034496 6.117292e-10 9.442700e-09 19 54459538 54459576 39 + 2.111 1.867 -0.822
ENSG00000167615 E037 139.0765709 0.0007327571 8.464081e-23 7.345373e-21 19 54459577 54459632 56 + 2.286 1.959 -1.094
ENSG00000167615 E038 136.9643958 0.0002202739 1.527705e-12 3.631812e-11 19 54459633 54459649 17 + 2.240 2.019 -0.738
ENSG00000167615 E039 768.0892067 0.0009202259 2.144007e-06 1.656507e-05 19 54459650 54460543 894 + 2.926 2.839 -0.291
ENSG00000167615 E040 59.7868168 0.0022267583 1.164032e-02 3.267676e-02 19 54460544 54460765 222 + 1.699 1.827 0.434
ENSG00000167615 E041 572.2620256 0.0001077506 1.473600e-52 1.037803e-49 19 54460766 54461225 460 + 2.606 2.842 0.784
ENSG00000167615 E042 471.8552243 0.0002069631 3.337543e-43 1.398866e-40 19 54461226 54461551 326 + 2.518 2.761 0.810
ENSG00000167615 E043 329.8882479 0.0072924671 6.700379e-08 7.038352e-07 19 54461552 54461692 141 + 2.360 2.614 0.846
ENSG00000167615 E044 225.6403450 0.0120412824 6.579893e-06 4.558737e-05 19 54461693 54461802 110 + 2.185 2.456 0.903
ENSG00000167615 E045 168.6744767 0.0200904528 3.341886e-06 2.477151e-05 19 54461803 54463949 2147 + 1.998 2.356 1.198