ENSG00000167566

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335999 ENSG00000167566 HEK293_OSMI2_2hA HEK293_TMG_2hB NCKAP5L protein_coding protein_coding 13.74721 20.21884 9.635639 1.65709 0.07885082 -1.068465 9.001914 12.807237 6.769057 1.2227141 0.14587017 -0.9189287 0.6537375 0.6319333 0.7025333 0.0706000 1.599514e-01 4.585165e-05 FALSE TRUE
ENST00000433948 ENSG00000167566 HEK293_OSMI2_2hA HEK293_TMG_2hB NCKAP5L protein_coding protein_coding 13.74721 20.21884 9.635639 1.65709 0.07885082 -1.068465 3.555179 6.588261 1.686679 0.3949791 0.07111491 -1.9593725 0.2446167 0.3283333 0.1749667 -0.1533667 4.585165e-05 4.585165e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167566 E001 0.8449086 0.0136968632 6.286788e-01 7.441740e-01 12 49791146 49791151 6 - 0.174 0.269 0.801
ENSG00000167566 E002 522.6060110 0.0054459205 5.008485e-07 4.429290e-06 12 49791152 49792051 900 - 2.511 2.709 0.660
ENSG00000167566 E003 67.6776263 0.0003619107 2.696376e-03 9.363058e-03 12 49792052 49792445 394 - 1.652 1.817 0.559
ENSG00000167566 E004 169.9486114 0.0019962418 2.987493e-05 1.778666e-04 12 49792446 49792588 143 - 2.043 2.217 0.582
ENSG00000167566 E005 199.5350761 0.0010291090 8.525032e-07 7.186907e-06 12 49792678 49792986 309 - 2.111 2.286 0.585
ENSG00000167566 E006 120.5043946 0.0002653118 2.170236e-04 1.036778e-03 12 49793352 49793433 82 - 1.910 2.063 0.515
ENSG00000167566 E007 152.7325376 0.0002311474 5.046100e-08 5.436890e-07 12 49793734 49793896 163 - 1.971 2.172 0.671
ENSG00000167566 E008 1040.4627124 0.0009683512 6.113335e-01 7.304424e-01 12 49794765 49797394 2630 - 2.952 2.964 0.040
ENSG00000167566 E009 89.0099705 0.0024488991 1.972402e-03 7.140152e-03 12 49798350 49798463 114 - 1.982 1.857 -0.420
ENSG00000167566 E010 104.7517192 0.0031802693 6.158132e-05 3.392578e-04 12 49801848 49801967 120 - 2.078 1.917 -0.539
ENSG00000167566 E011 12.1853430 0.0015577179 1.733605e-10 2.936573e-09 12 49802268 49802723 456 - 1.409 0.819 -2.138
ENSG00000167566 E012 4.0330050 0.0043198773 1.034148e-04 5.378471e-04 12 49802724 49802754 31 - 0.972 0.435 -2.282
ENSG00000167566 E013 11.5824386 0.0053076679 3.445496e-06 2.545982e-05 12 49802755 49802957 203 - 1.326 0.873 -1.644
ENSG00000167566 E014 67.5103433 0.0103084703 1.710535e-02 4.517590e-02 12 49802958 49802996 39 - 1.874 1.740 -0.455
ENSG00000167566 E015 3.5540826 0.2083985503 1.288140e-01 2.325021e-01 12 49802997 49803096 100 - 0.807 0.526 -1.198
ENSG00000167566 E016 81.3371347 0.0082709857 1.376205e-03 5.228790e-03 12 49803097 49803165 69 - 1.976 1.808 -0.565
ENSG00000167566 E017 106.7119315 0.0039430774 1.534307e-05 9.769432e-05 12 49803922 49804050 129 - 2.101 1.920 -0.605
ENSG00000167566 E018 65.1589326 0.0011486044 6.900582e-09 8.764965e-08 12 49804051 49804080 30 - 1.938 1.682 -0.863
ENSG00000167566 E019 21.4823758 0.0010544710 2.687892e-07 2.511655e-06 12 49804081 49805719 1639 - 1.538 1.169 -1.283
ENSG00000167566 E020 1.3232892 0.0148223635 6.006144e-02 1.267061e-01 12 49805938 49805979 42 - 0.539 0.216 -1.930
ENSG00000167566 E021 81.3487309 0.0003811984 7.139007e-10 1.089466e-08 12 49805980 49806041 62 - 2.017 1.781 -0.793
ENSG00000167566 E022 2.1243799 0.4008807500 2.971051e-01 4.384117e-01 12 49816906 49816984 79 - 0.691 0.323 -1.823
ENSG00000167566 E023 66.8833546 0.0018428394 3.665882e-07 3.331848e-06 12 49828322 49828750 429 - 1.933 1.703 -0.774