ENSG00000167535

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301050 ENSG00000167535 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNB3 protein_coding protein_coding 5.535778 8.685505 3.493301 1.025481 0.3916011 -1.311555 1.2970003 2.07443970 0.9552921 0.39167202 0.07942297 -1.110622 0.23633333 0.241366667 0.28306667 0.04170000 8.234039e-01 3.972727e-09 FALSE TRUE
ENST00000536187 ENSG00000167535 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNB3 protein_coding protein_coding 5.535778 8.685505 3.493301 1.025481 0.3916011 -1.311555 1.1315413 1.89542986 0.6506198 0.46455570 0.32666386 -1.528224 0.20540833 0.214466667 0.17863333 -0.03583333 8.349254e-01 3.972727e-09 FALSE TRUE
ENST00000547230 ENSG00000167535 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNB3 protein_coding protein_coding 5.535778 8.685505 3.493301 1.025481 0.3916011 -1.311555 0.8683698 2.45913767 0.0000000 0.45519980 0.00000000 -7.947863 0.13970417 0.292766667 0.00000000 -0.29276667 3.972727e-09 3.972727e-09 FALSE TRUE
ENST00000550483 ENSG00000167535 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNB3 protein_coding nonsense_mediated_decay 5.535778 8.685505 3.493301 1.025481 0.3916011 -1.311555 0.2871194 0.50546024 0.1895714 0.13097024 0.04374892 -1.368956 0.05678333 0.056433333 0.05303333 -0.00340000 1.000000e+00 3.972727e-09   FALSE
ENST00000551544 ENSG00000167535 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNB3 protein_coding nonsense_mediated_decay 5.535778 8.685505 3.493301 1.025481 0.3916011 -1.311555 0.2327790 0.03012869 0.3457794 0.03012869 0.17318584 3.148277 0.04390833 0.003466667 0.09716667 0.09370000 2.349237e-01 3.972727e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167535 E001 0.0000000       12 48813794 48813843 50 +      
ENSG00000167535 E002 0.0000000       12 48814432 48814450 19 +      
ENSG00000167535 E003 0.0000000       12 48814451 48814479 29 +      
ENSG00000167535 E004 0.3686942 0.0269403108 0.485766271 0.623580345 12 48814480 48814553 74 + 0.181 0.081 -1.332
ENSG00000167535 E005 2.7398041 0.0056078261 0.001781962 0.006542389 12 48814893 48815586 694 + 0.825 0.348 -2.209
ENSG00000167535 E006 0.6621601 0.0175550852 0.353172760 0.497414882 12 48815587 48815590 4 + 0.308 0.149 -1.335
ENSG00000167535 E007 2.3896404 0.0062731357 0.293226124 0.434268902 12 48815591 48815599 9 + 0.308 0.513 1.126
ENSG00000167535 E008 2.3896404 0.0062731357 0.293226124 0.434268902 12 48815600 48815601 2 + 0.308 0.513 1.126
ENSG00000167535 E009 3.6000342 0.0046178494 0.177683281 0.298216078 12 48815602 48815611 10 + 0.407 0.652 1.169
ENSG00000167535 E010 9.9292622 0.0017543860 0.803718947 0.875099965 12 48815612 48815728 117 + 0.942 0.983 0.151
ENSG00000167535 E011 4.0545804 0.0041573530 0.856135269 0.911060021 12 48816873 48816928 56 + 0.613 0.652 0.168
ENSG00000167535 E012 4.0180488 0.0040842041 0.780378462 0.858857871 12 48816929 48816995 67 + 0.665 0.632 -0.142
ENSG00000167535 E013 2.9046427 0.0513784624 0.052147708 0.112982923 12 48816996 48817260 265 + 0.752 0.425 -1.486
ENSG00000167535 E014 1.0298102 0.1387092766 0.085795339 0.168664268 12 48817261 48817312 52 + 0.486 0.152 -2.306
ENSG00000167535 E015 1.8339338 0.0106051686 0.068017998 0.140079017 12 48817370 48817514 145 + 0.613 0.307 -1.596
ENSG00000167535 E016 0.5212538 0.0212586465 0.824620070 0.889531298 12 48817866 48817963 98 + 0.181 0.149 -0.335
ENSG00000167535 E017 0.3030308 0.4321008101 0.097271609   12 48818386 48818405 20 + 0.310 0.000 -11.163
ENSG00000167535 E018 0.6319842 0.0246871637 0.053761290 0.115835079 12 48818406 48818483 78 + 0.407 0.081 -2.920
ENSG00000167535 E019 0.8836184 0.0158385794 0.561685723 0.689436353 12 48818484 48818495 12 + 0.308 0.208 -0.748
ENSG00000167535 E020 1.1802048 0.0113095609 0.964065542 0.981338009 12 48818496 48818503 8 + 0.308 0.306 -0.014
ENSG00000167535 E021 4.0699320 0.0466069689 0.131788621 0.236613269 12 48818504 48818522 19 + 0.407 0.709 1.408
ENSG00000167535 E022 5.6659733 0.0334733062 0.455555719 0.596081530 12 48818523 48818558 36 + 0.665 0.801 0.556
ENSG00000167535 E023 7.5126177 0.0912964205 0.788453598 0.864582570 12 48818559 48818786 228 + 0.826 0.889 0.243
ENSG00000167535 E024 1.5156027 0.1593702261 0.150146706 0.261867587 12 48818787 48818792 6 + 0.555 0.263 -1.640
ENSG00000167535 E025 5.8510638 0.0795904766 0.390427828 0.534393329 12 48818793 48818908 116 + 0.858 0.735 -0.485
ENSG00000167535 E026 7.9440281 0.0082103448 0.463560523 0.603342260 12 48818909 48818974 66 + 0.790 0.903 0.438
ENSG00000167535 E027 1.0822641 0.1910214180 0.008951606 0.026158893 12 48819636 48819777 142 + 0.614 0.081 -3.923
ENSG00000167535 E028 1.2262909 0.0280505599 0.007493969 0.022496512 12 48819778 48819942 165 + 0.613 0.149 -2.923
ENSG00000167535 E029 2.3780043 0.0665255655 0.026068857 0.064085263 12 48819943 48820557 615 + 0.751 0.348 -1.918
ENSG00000167535 E030 0.9127647 0.0699271175 0.064330858 0.133917413 12 48820558 48820688 131 + 0.486 0.149 -2.338
ENSG00000167535 E031 2.7345056 0.0056866530 0.008304644 0.024556562 12 48820689 48821489 801 + 0.790 0.386 -1.850
ENSG00000167535 E032 28.6634151 0.0010051727 0.019919854 0.051321282 12 48823344 48823445 102 + 1.505 1.357 -0.512
ENSG00000167535 E033 21.6720179 0.0010876653 0.001539024 0.005763149 12 48823446 48823466 21 + 1.445 1.214 -0.805
ENSG00000167535 E034 34.0338080 0.0007457974 0.038942189 0.089080645 12 48823681 48823778 98 + 1.558 1.439 -0.410
ENSG00000167535 E035 20.3537838 0.0009593043 0.516072240 0.650652071 12 48823779 48823803 25 + 1.292 1.251 -0.147
ENSG00000167535 E036 0.5149111 0.0213758908 0.825081527 0.889814249 12 48823804 48823984 181 + 0.181 0.149 -0.335
ENSG00000167535 E037 13.7406170 0.0013078867 0.357369926 0.501776235 12 48824258 48824260 3 + 1.160 1.082 -0.280
ENSG00000167535 E038 32.7450612 0.0006937477 0.605006469 0.725435676 12 48824261 48824373 113 + 1.476 1.454 -0.076
ENSG00000167535 E039 30.0280984 0.0006854416 0.596177591 0.718153851 12 48824669 48824733 65 + 1.385 1.435 0.174
ENSG00000167535 E040 3.6222730 0.0114635532 0.930658638 0.960365014 12 48824734 48824948 215 + 0.613 0.610 -0.013
ENSG00000167535 E041 16.5041137 0.0045701942 0.780415937 0.858889136 12 48824949 48824968 20 + 1.190 1.175 -0.053
ENSG00000167535 E042 3.6105336 0.0045018686 0.192159841 0.316466627 12 48824969 48825114 146 + 0.752 0.564 -0.805
ENSG00000167535 E043 3.5729708 0.0049828897 0.030349100 0.072657181 12 48825115 48825162 48 + 0.825 0.512 -1.335
ENSG00000167535 E044 34.5944837 0.0006868996 0.958609145 0.978062283 12 48825163 48825243 81 + 1.469 1.485 0.055
ENSG00000167535 E045 33.6663173 0.0006791010 0.526167788 0.659431001 12 48825434 48825492 59 + 1.429 1.485 0.192
ENSG00000167535 E046 43.3272046 0.0005712700 0.335117257 0.478882071 12 48825660 48825769 110 + 1.519 1.590 0.243
ENSG00000167535 E047 4.4762683 0.0267279636 0.293151966 0.434189623 12 48826245 48826366 122 + 0.790 0.633 -0.647
ENSG00000167535 E048 29.2122207 0.0028781104 0.849264058 0.906420403 12 48826367 48826419 53 + 1.403 1.403 0.000
ENSG00000167535 E049 38.0256606 0.0005850780 0.722335424 0.816473826 12 48826420 48826518 99 + 1.491 1.526 0.121
ENSG00000167535 E050 43.0559237 0.0005465657 0.376027186 0.520408967 12 48826759 48826854 96 + 1.519 1.586 0.228
ENSG00000167535 E051 53.5376953 0.0101632881 0.307465437 0.449697399 12 48826974 48827123 150 + 1.588 1.687 0.336
ENSG00000167535 E052 197.7415626 0.0065785287 0.022623452 0.056967437 12 48827585 48828661 1077 + 2.145 2.258 0.378
ENSG00000167535 E053 40.4497555 0.0182534755 0.062825840 0.131414437 12 48828662 48828941 280 + 1.411 1.595 0.629