ENSG00000167525

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301039 ENSG00000167525 HEK293_OSMI2_2hA HEK293_TMG_2hB PROCA1 protein_coding protein_coding 1.487642 2.324281 0.7654877 0.3582865 0.0574546 -1.589803 0.51271063 0.96642114 0.42001057 0.05538318 0.07896297 -1.183131 0.32690417 0.43253333 0.54610000 0.11356667 6.551924e-01 5.008476e-06 FALSE TRUE
ENST00000415329 ENSG00000167525 HEK293_OSMI2_2hA HEK293_TMG_2hB PROCA1 protein_coding protein_coding 1.487642 2.324281 0.7654877 0.3582865 0.0574546 -1.589803 0.04294842 0.34358736 0.00000000 0.34358736 0.00000000 -5.143995 0.01444583 0.11556667 0.00000000 -0.11556667 9.427228e-01 5.008476e-06 FALSE FALSE
ENST00000422880 ENSG00000167525 HEK293_OSMI2_2hA HEK293_TMG_2hB PROCA1 protein_coding processed_transcript 1.487642 2.324281 0.7654877 0.3582865 0.0574546 -1.589803 0.02291546 0.10689052 0.00000000 0.08213566 0.00000000 -3.547086 0.01752500 0.05736667 0.00000000 -0.05736667 7.276953e-01 5.008476e-06 FALSE FALSE
ENST00000495203 ENSG00000167525 HEK293_OSMI2_2hA HEK293_TMG_2hB PROCA1 protein_coding retained_intron 1.487642 2.324281 0.7654877 0.3582865 0.0574546 -1.589803 0.32858329 0.30285826 0.10847155 0.02987172 0.03570460 -1.400968 0.23037083 0.13390000 0.14786667 0.01396667 9.159734e-01 5.008476e-06 FALSE FALSE
ENST00000579650 ENSG00000167525 HEK293_OSMI2_2hA HEK293_TMG_2hB PROCA1 protein_coding processed_transcript 1.487642 2.324281 0.7654877 0.3582865 0.0574546 -1.589803 0.11475099 0.02353821 0.21369406 0.02353821 0.03610116 2.737649 0.09290417 0.01040000 0.27543333 0.26503333 5.008476e-06 5.008476e-06   FALSE
ENST00000674362 ENSG00000167525 HEK293_OSMI2_2hA HEK293_TMG_2hB PROCA1 protein_coding processed_transcript 1.487642 2.324281 0.7654877 0.3582865 0.0574546 -1.589803 0.37376554 0.54787716 0.02331148 0.21684453 0.02331148 -4.065856 0.24083750 0.23563333 0.03056667 -0.20506667 1.270826e-01 5.008476e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167525 E001 2.6558620 0.022482576 0.0939913852 0.181366544 17 28703197 28703280 84 - 0.208 0.553 2.071
ENSG00000167525 E002 9.1844017 0.093818171 0.9727718962 0.987015964 17 28703281 28703515 235 - 0.922 0.921 -0.004
ENSG00000167525 E003 11.1960710 0.001763514 0.4608683031 0.600854156 17 28703516 28703624 109 - 0.922 1.007 0.317
ENSG00000167525 E004 12.4880097 0.001554033 0.3853485801 0.529536978 17 28703625 28703713 89 - 0.953 1.049 0.356
ENSG00000167525 E005 21.0901430 0.028332096 0.5291068586 0.661940877 17 28703714 28703915 202 - 1.179 1.253 0.262
ENSG00000167525 E006 8.6355591 0.036016158 0.6797062288 0.783806067 17 28703916 28704007 92 - 0.922 0.872 -0.188
ENSG00000167525 E007 6.8933406 0.003433817 0.8112059697 0.880205646 17 28704008 28704080 73 - 0.771 0.804 0.129
ENSG00000167525 E008 4.9746040 0.004015180 0.7879772836 0.864193566 17 28704081 28704083 3 - 0.723 0.681 -0.174
ENSG00000167525 E009 9.5104809 0.002083962 0.4702189990 0.609425672 17 28704084 28704212 129 - 0.853 0.943 0.344
ENSG00000167525 E010 10.2781837 0.001876590 0.1990991230 0.325097020 17 28704307 28704435 129 - 0.814 0.976 0.620
ENSG00000167525 E011 2.7760295 0.014320257 0.2935549407 0.434630166 17 28704436 28704530 95 - 0.347 0.554 1.073
ENSG00000167525 E012 3.6994904 0.005606769 0.5610199833 0.688927186 17 28704531 28704616 86 - 0.670 0.576 -0.412
ENSG00000167525 E013 9.4884732 0.002146932 0.7831023131 0.860765540 17 28704708 28704843 136 - 0.953 0.917 -0.134
ENSG00000167525 E014 7.6191285 0.002495420 0.6431673261 0.755770777 17 28704844 28705832 989 - 0.889 0.826 -0.240
ENSG00000167525 E015 5.8520051 0.004080737 0.8971659800 0.938329943 17 28705833 28706676 844 - 0.723 0.740 0.069
ENSG00000167525 E016 0.6966155 0.017267182 0.8915526531 0.934747277 17 28706677 28706679 3 - 0.208 0.181 -0.240
ENSG00000167525 E017 1.3964532 0.011139584 0.3296189248 0.473139462 17 28706680 28706763 84 - 0.453 0.271 -1.087
ENSG00000167525 E018 0.9212829 0.019796846 0.3756940169 0.520099852 17 28706764 28706773 10 - 0.347 0.182 -1.237
ENSG00000167525 E019 4.9361240 0.003835958 0.1259758063 0.228537735 17 28706774 28707449 676 - 0.853 0.632 -0.899
ENSG00000167525 E020 2.4573206 0.038760289 0.8512796161 0.907781990 17 28707838 28707883 46 - 0.453 0.486 0.164
ENSG00000167525 E021 2.6120583 0.014545714 0.4056581352 0.549318214 17 28709872 28710104 233 - 0.609 0.462 -0.692
ENSG00000167525 E022 3.8183786 0.040640636 0.0006644999 0.002768706 17 28710871 28711569 699 - 0.981 0.436 -2.312
ENSG00000167525 E023 1.6834877 0.057935010 0.8620377505 0.915073432 17 28711570 28711582 13 - 0.347 0.376 0.171
ENSG00000167525 E024 5.9458960 0.087050350 0.8748612998 0.923588752 17 28711583 28711888 306 - 0.723 0.749 0.104