ENSG00000167523

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000457689 ENSG00000167523 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA33 protein_coding nonsense_mediated_decay 17.25249 29.17652 12.39931 0.900198 0.1466265 -1.233879 3.0715320 6.264063 2.0823522 0.7014130 0.23033979 -1.58427436 0.16746250 0.21450000 0.16836667 -0.04613333 5.430104e-01 4.600708e-18 FALSE TRUE
ENST00000565890 ENSG00000167523 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA33 protein_coding nonsense_mediated_decay 17.25249 29.17652 12.39931 0.900198 0.1466265 -1.233879 1.8763445 2.464087 0.7489169 0.3611758 0.07272398 -1.70488235 0.10613750 0.08486667 0.06030000 -0.02456667 4.498300e-01 4.600708e-18   FALSE
ENST00000568929 ENSG00000167523 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA33 protein_coding protein_coding 17.25249 29.17652 12.39931 0.900198 0.1466265 -1.233879 2.8729138 3.627341 1.6733557 0.5514800 0.45669621 -1.11154421 0.17632917 0.12560000 0.13430000 0.00870000 9.920097e-01 4.600708e-18   FALSE
ENST00000611218 ENSG00000167523 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA33 protein_coding protein_coding 17.25249 29.17652 12.39931 0.900198 0.1466265 -1.233879 1.6842447 1.541756 1.5288552 0.1281891 0.09468077 -0.01204448 0.11032083 0.05280000 0.12340000 0.07060000 3.687145e-05 4.600708e-18 FALSE FALSE
MSTRG.13280.10 ENSG00000167523 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA33 protein_coding   17.25249 29.17652 12.39931 0.900198 0.1466265 -1.233879 1.4050798 3.999622 1.2040517 0.5488632 0.37651087 -1.72363637 0.06897083 0.13656667 0.09763333 -0.03893333 6.189183e-01 4.600708e-18 TRUE TRUE
MSTRG.13280.24 ENSG00000167523 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA33 protein_coding   17.25249 29.17652 12.39931 0.900198 0.1466265 -1.233879 1.7286377 3.230024 1.9343599 0.2449811 0.34837945 -0.73670929 0.10068333 0.11056667 0.15583333 0.04526667 4.413272e-01 4.600708e-18   FALSE
MSTRG.13280.27 ENSG00000167523 HEK293_OSMI2_2hA HEK293_TMG_2hB SPATA33 protein_coding   17.25249 29.17652 12.39931 0.900198 0.1466265 -1.233879 0.7861007 3.014219 0.0000000 0.4745704 0.00000000 -8.24041870 0.03421250 0.10256667 0.00000000 -0.10256667 4.600708e-18 4.600708e-18   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167523 E001 0.1817044 0.0407995193 1.000000e+00   16 89657740 89657773 34 + 0.000 0.080 8.475
ENSG00000167523 E002 0.4031496 0.0256071673 5.921508e-01 0.7147620398 16 89657774 89657777 4 + 0.000 0.148 11.809
ENSG00000167523 E003 0.5514428 0.0197824746 3.468550e-01 0.4910008115 16 89657778 89657779 2 + 0.000 0.206 12.430
ENSG00000167523 E004 3.4290432 0.0061417722 1.204379e-01 0.2205931051 16 89657780 89657801 22 + 0.757 0.509 -1.079
ENSG00000167523 E005 14.3584469 0.0018004361 9.483228e-02 0.1826338435 16 89657802 89657828 27 + 1.236 1.069 -0.596
ENSG00000167523 E006 17.8689609 0.0016347352 3.426676e-02 0.0802707407 16 89657829 89657835 7 + 1.341 1.151 -0.669
ENSG00000167523 E007 4.7659617 0.0034433594 6.185027e-02 0.1297343595 16 89657836 89657837 2 + 0.892 0.627 -1.072
ENSG00000167523 E008 14.8452333 0.0099278368 3.581441e-02 0.0832221199 16 89657838 89657860 23 + 1.286 1.064 -0.793
ENSG00000167523 E009 15.8437337 0.0105477821 3.939426e-02 0.0899063389 16 89657861 89657866 6 + 1.309 1.093 -0.767
ENSG00000167523 E010 16.9906265 0.0161597606 1.209495e-01 0.2213012236 16 89657867 89657870 4 + 1.309 1.135 -0.616
ENSG00000167523 E011 28.0304926 0.0182056397 1.884354e-01 0.3117611688 16 89657871 89657948 78 + 1.490 1.354 -0.469
ENSG00000167523 E012 3.8978551 0.0150385977 9.129644e-01 0.9488832101 16 89657949 89658046 98 + 0.617 0.628 0.050
ENSG00000167523 E013 4.1684052 0.0042033315 9.249746e-01 0.9567567474 16 89658047 89658049 3 + 0.669 0.648 -0.090
ENSG00000167523 E014 64.7089289 0.0004437958 4.787278e-01 0.6171560430 16 89658050 89658101 52 + 1.731 1.758 0.090
ENSG00000167523 E015 124.4263230 0.0014692497 7.955138e-01 0.8694089691 16 89658102 89658209 108 + 2.045 2.027 -0.061
ENSG00000167523 E016 22.0042013 0.0085693914 1.090628e-03 0.0042720208 16 89658210 89658247 38 + 1.496 1.209 -0.999
ENSG00000167523 E017 118.6472946 0.0042098210 5.836927e-02 0.1238326479 16 89658248 89658421 174 + 2.078 1.984 -0.318
ENSG00000167523 E018 2.6561527 0.0082996899 6.803155e-01 0.7842299613 16 89658422 89658577 156 + 0.558 0.481 -0.368
ENSG00000167523 E019 25.3400275 0.0079098082 1.260463e-02 0.0349799935 16 89658578 89660539 1962 + 1.504 1.293 -0.730
ENSG00000167523 E020 61.7143726 0.0096392323 5.715813e-01 0.6978344172 16 89660540 89660827 288 + 1.767 1.725 -0.144
ENSG00000167523 E021 65.2848288 0.0338741455 4.079108e-01 0.5515053074 16 89660828 89661111 284 + 1.821 1.736 -0.288
ENSG00000167523 E022 39.3658226 0.0092617699 9.861535e-01 0.9953423375 16 89661112 89661300 189 + 1.551 1.545 -0.018
ENSG00000167523 E023 12.8913083 0.0014563043 2.279303e-01 0.3599593017 16 89661301 89661327 27 + 1.180 1.054 -0.454
ENSG00000167523 E024 18.6148815 0.0076794640 3.235188e-01 0.4668470180 16 89661328 89661412 85 + 1.309 1.212 -0.340
ENSG00000167523 E025 13.1619434 0.0024741924 6.792482e-01 0.7834915826 16 89661413 89661508 96 + 1.132 1.083 -0.176
ENSG00000167523 E026 0.6652806 0.0183390657 9.001106e-01 0.9402580273 16 89667993 89668044 52 + 0.183 0.206 0.213
ENSG00000167523 E027 10.1172127 0.0019080042 2.645113e-01 0.4024710345 16 89668171 89668382 212 + 1.079 0.949 -0.477
ENSG00000167523 E028 292.1530665 0.0002447605 7.598326e-05 0.0004090013 16 89669286 89669603 318 + 2.336 2.419 0.277
ENSG00000167523 E029 94.3561222 0.0003336486 1.539392e-02 0.0413846164 16 89669604 89669731 128 + 1.839 1.932 0.314
ENSG00000167523 E030 41.2204917 0.0006248936 5.989315e-01 0.7204313617 16 89669732 89669741 10 + 1.544 1.568 0.082
ENSG00000167523 E031 54.4125963 0.0004570002 4.366903e-01 0.5787314416 16 89669742 89669794 53 + 1.653 1.686 0.113
ENSG00000167523 E032 33.7120098 0.0005944551 1.293802e-01 0.2333173791 16 89669795 89669804 10 + 1.399 1.496 0.335
ENSG00000167523 E033 49.3209132 0.0004882488 2.810015e-01 0.4208707467 16 89669805 89669858 54 + 1.593 1.647 0.181
ENSG00000167523 E034 55.6500220 0.0048553589 8.647098e-02 0.1697599814 16 89669859 89669922 64 + 1.605 1.705 0.339
ENSG00000167523 E035 38.5015458 0.0006661888 2.682130e-02 0.0656207902 16 89669923 89669932 10 + 1.417 1.557 0.480
ENSG00000167523 E036 53.2178252 0.0005269643 9.212028e-02 0.1784266599 16 89669933 89669982 50 + 1.599 1.685 0.291
ENSG00000167523 E037 53.2587816 0.0004828867 5.077593e-01 0.6431980391 16 89669983 89670035 53 + 1.648 1.675 0.093
ENSG00000167523 E038 40.7751028 0.0300929426 7.686119e-01 0.8504532849 16 89670036 89670045 10 + 1.589 1.547 -0.140
ENSG00000167523 E039 70.9999291 0.0031315437 3.980873e-01 0.5418275571 16 89670046 89670109 64 + 1.764 1.800 0.121
ENSG00000167523 E040 96.7167319 0.0043061892 5.193617e-04 0.0022322645 16 89670110 89670298 189 + 1.783 1.959 0.591
ENSG00000167523 E041 137.8497566 0.0042651081 1.433516e-03 0.0054185025 16 89670299 89671272 974 + 2.181 2.035 -0.489