ENSG00000167508

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000301012 ENSG00000167508 HEK293_OSMI2_2hA HEK293_TMG_2hB MVD protein_coding protein_coding 76.61743 148.8271 26.19245 6.708402 0.9317001 -2.505961 54.28589 115.5223 14.85414 2.982261 0.2905287 -2.958389 0.6542833 0.7775333 0.5688333 -0.2087 1.726621e-06 1.726621e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167508 E001 4.566267 0.0037115140 5.801900e-01 7.049781e-01 16 88651935 88651939 5 - 0.451 0.565 0.551
ENSG00000167508 E002 243.098337 0.0021309806 1.553564e-02 4.170347e-02 16 88651940 88652051 112 - 2.061 2.167 0.357
ENSG00000167508 E003 269.238768 0.0012795714 6.419277e-02 1.336828e-01 16 88652052 88652087 36 - 2.136 2.208 0.241
ENSG00000167508 E004 913.911389 0.0003320514 2.018660e-15 7.324842e-14 16 88652088 88652341 254 - 2.569 2.744 0.584
ENSG00000167508 E005 419.320419 0.0013479903 7.958046e-09 9.994882e-08 16 88652342 88652353 12 - 2.198 2.408 0.701
ENSG00000167508 E006 940.253361 0.0007659016 3.008018e-06 2.250010e-05 16 88652354 88652509 156 - 2.643 2.752 0.361
ENSG00000167508 E007 678.513095 0.0003464307 3.610959e-03 1.204142e-02 16 88652510 88652605 96 - 2.539 2.607 0.228
ENSG00000167508 E008 655.559202 0.0001207746 1.158954e-02 3.255930e-02 16 88653300 88653408 109 - 2.534 2.590 0.187
ENSG00000167508 E009 15.759541 0.0353811643 7.393685e-02 1.498103e-01 16 88653409 88653584 176 - 1.217 0.970 -0.895
ENSG00000167508 E010 794.884411 0.0001094143 4.060690e-02 9.213774e-02 16 88654692 88654807 116 - 2.707 2.665 -0.142
ENSG00000167508 E011 6.000089 0.0031227177 7.093252e-06 4.877837e-05 16 88654808 88654985 178 - 1.167 0.551 -2.422
ENSG00000167508 E012 836.620922 0.0001137839 7.384258e-05 3.985544e-04 16 88655199 88655384 186 - 2.760 2.683 -0.256
ENSG00000167508 E013 320.654024 0.0001614298 8.792490e-01 9.264295e-01 16 88655385 88655417 33 - 2.282 2.275 -0.024
ENSG00000167508 E014 229.974548 0.0001757818 3.280242e-01 4.714783e-01 16 88655656 88655656 1 - 2.100 2.136 0.119
ENSG00000167508 E015 244.731026 0.0001687626 6.240841e-01 7.405350e-01 16 88655657 88655662 6 - 2.145 2.161 0.053
ENSG00000167508 E016 429.786144 0.0020959342 8.396631e-01 8.998386e-01 16 88655663 88655730 68 - 2.410 2.403 -0.023
ENSG00000167508 E017 13.444591 0.0625630162 6.611821e-02 1.369110e-01 16 88655834 88656104 271 - 1.194 0.904 -1.059
ENSG00000167508 E018 297.440011 0.0020378964 7.056942e-01 8.040182e-01 16 88656105 88656120 16 - 2.259 2.244 -0.050
ENSG00000167508 E019 406.638244 0.0011884029 9.101714e-01 9.469014e-01 16 88656121 88656169 49 - 2.383 2.379 -0.014
ENSG00000167508 E020 561.476589 0.0001556892 6.957568e-01 7.962705e-01 16 88656170 88656260 91 - 2.512 2.519 0.025
ENSG00000167508 E021 424.571496 0.0001718732 5.373421e-01 6.689238e-01 16 88656261 88656304 44 - 2.382 2.397 0.050
ENSG00000167508 E022 28.262187 0.0560825431 1.940958e-01 3.189245e-01 16 88656305 88656561 257 - 1.410 1.218 -0.670
ENSG00000167508 E023 13.628955 0.0016733043 1.915575e-05 1.193514e-04 16 88656562 88656794 233 - 1.342 0.869 -1.714
ENSG00000167508 E024 6.984000 0.0211230459 1.115063e-03 4.354049e-03 16 88656795 88656857 63 - 1.109 0.619 -1.907
ENSG00000167508 E025 16.839118 0.0239186668 5.965610e-05 3.297351e-04 16 88656858 88657145 288 - 1.438 0.954 -1.727
ENSG00000167508 E026 19.907388 0.0009552614 7.961207e-03 2.367889e-02 16 88657146 88657247 102 - 1.342 1.068 -0.973
ENSG00000167508 E027 5.851779 0.0032173761 1.626920e-02 4.331906e-02 16 88657248 88657266 19 - 0.964 0.591 -1.499
ENSG00000167508 E028 738.147396 0.0008252855 2.299627e-02 5.774071e-02 16 88657436 88657582 147 - 2.585 2.641 0.184
ENSG00000167508 E029 32.300205 0.0009567015 1.192193e-09 1.741249e-08 16 88657583 88657734 152 - 1.685 1.219 -1.606
ENSG00000167508 E030 40.795710 0.0110486143 5.955680e-07 5.191578e-06 16 88657735 88657914 180 - 1.746 1.327 -1.433
ENSG00000167508 E031 409.872599 0.0029800081 1.039860e-01 1.965701e-01 16 88657915 88657943 29 - 2.324 2.386 0.209
ENSG00000167508 E032 699.984735 0.0011025000 1.120561e-01 2.085620e-01 16 88657944 88658029 86 - 2.651 2.608 -0.143
ENSG00000167508 E033 567.726394 0.0019614926 1.273564e-03 4.888916e-03 16 88658650 88658720 71 - 2.611 2.512 -0.332
ENSG00000167508 E034 4.053449 0.0040257761 1.915021e-02 4.966179e-02 16 88658721 88658783 63 - 0.868 0.473 -1.694
ENSG00000167508 E035 23.898539 0.0008451033 3.300443e-10 5.333610e-09 16 88658973 88659328 356 - 1.614 1.085 -1.847
ENSG00000167508 E036 72.667988 0.0010917147 2.146746e-05 1.321217e-04 16 88660520 88660637 118 - 1.858 1.605 -0.856
ENSG00000167508 E037 42.304865 0.0057658057 6.509060e-04 2.719062e-03 16 88660748 88660838 91 - 1.651 1.373 -0.953
ENSG00000167508 E038 10.596558 0.0016970168 1.817990e-03 6.657120e-03 16 88660839 88660841 3 - 1.193 0.802 -1.450
ENSG00000167508 E039 4.168232 0.0120676497 2.363778e-03 8.349381e-03 16 88660842 88660872 31 - 0.964 0.472 -2.062
ENSG00000167508 E040 8.870375 0.0030133720 1.370651e-07 1.356311e-06 16 88662102 88662114 13 - 1.304 0.663 -2.410
ENSG00000167508 E041 12.463890 0.0019466672 2.010453e-05 1.246275e-04 16 88662115 88662167 53 - 1.324 0.840 -1.760
ENSG00000167508 E042 12.725536 0.0255669614 1.265309e-07 1.260432e-06 16 88662712 88662781 70 - 1.453 0.797 -2.375
ENSG00000167508 E043 12.081550 0.0632916415 6.298045e-07 5.462121e-06 16 88662782 88662907 126 - 1.493 0.743 -2.733
ENSG00000167508 E044 11.314800 0.0620254871 1.750854e-05 1.100110e-04 16 88662961 88663010 50 - 1.410 0.750 -2.415
ENSG00000167508 E045 464.827836 0.0014960192 5.602063e-04 2.385574e-03 16 88663011 88663161 151 - 2.531 2.424 -0.357