ENSG00000167468

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354171 ENSG00000167468 HEK293_OSMI2_2hA HEK293_TMG_2hB GPX4 protein_coding protein_coding 1014.011 1967.537 497.6443 88.83534 6.735161 -1.983182 96.95359 158.63784 50.56682 32.672106 7.840922 -1.6492797 0.08900417 0.07963333 0.1018000 0.02216667 6.981076e-01 7.367048e-15   FALSE
ENST00000587648 ENSG00000167468 HEK293_OSMI2_2hA HEK293_TMG_2hB GPX4 protein_coding protein_coding 1014.011 1967.537 497.6443 88.83534 6.735161 -1.983182 72.78119 64.06833 70.42421 7.942144 10.703471 0.1364396 0.09922083 0.03306667 0.1414000 0.10833333 9.972964e-07 7.367048e-15   FALSE
ENST00000611653 ENSG00000167468 HEK293_OSMI2_2hA HEK293_TMG_2hB GPX4 protein_coding protein_coding 1014.011 1967.537 497.6443 88.83534 6.735161 -1.983182 773.51375 1620.85003 332.36932 65.328895 2.530312 -2.2858570 0.73748333 0.82426667 0.6680333 -0.15623333 7.367048e-15 7.367048e-15   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167468 E001 0.3634088 3.789868e-01 1.000000e+00   19 1103960 1103963 4 + 0.000 0.116 8.173
ENSG00000167468 E002 1.4652501 3.184920e-02 7.064865e-01 8.046324e-01 19 1103964 1103993 30 + 0.230 0.315 0.609
ENSG00000167468 E003 10.0025753 2.251357e-02 3.573070e-05 2.084010e-04 19 1103994 1104007 14 + 1.298 0.789 -1.873
ENSG00000167468 E004 217.2205078 1.908975e-02 1.561861e-01 2.700514e-01 19 1104008 1104051 44 + 2.269 2.180 -0.298
ENSG00000167468 E005 511.1240471 8.596545e-03 5.032920e-02 1.097509e-01 19 1104052 1104066 15 + 2.633 2.551 -0.272
ENSG00000167468 E006 1773.0882499 3.564019e-03 6.755581e-02 1.392900e-01 19 1104067 1104072 6 + 3.141 3.098 -0.142
ENSG00000167468 E007 4956.7591970 2.112897e-03 7.478294e-01 8.352466e-01 19 1104073 1104127 55 + 3.544 3.552 0.028
ENSG00000167468 E008 40.5614673 2.309956e-02 1.119071e-01 2.083747e-01 19 1104415 1104673 259 + 1.588 1.450 -0.475
ENSG00000167468 E009 34.7164115 2.641606e-02 1.499288e-02 4.047188e-02 19 1104674 1104705 32 + 1.596 1.362 -0.805
ENSG00000167468 E010 25.7380209 1.736845e-02 2.961436e-09 4.022623e-08 19 1104706 1104742 37 + 1.686 1.140 -1.892
ENSG00000167468 E011 382.6523163 2.085742e-04 2.448988e-05 1.489130e-04 19 1104743 1104929 187 + 2.512 2.421 -0.304
ENSG00000167468 E012 45.5997374 7.269420e-03 5.183511e-03 1.642801e-02 19 1105152 1105155 4 + 1.680 1.485 -0.664
ENSG00000167468 E013 81.8093597 3.393476e-03 1.826121e-06 1.432993e-05 19 1105156 1105185 30 + 1.970 1.726 -0.822
ENSG00000167468 E014 7660.3447771 1.381403e-03 1.252246e-01 2.274523e-01 19 1105186 1105252 67 + 3.750 3.738 -0.040
ENSG00000167468 E015 5332.4832642 2.167303e-04 1.769312e-14 5.619294e-13 19 1105253 1105274 22 + 3.630 3.572 -0.193
ENSG00000167468 E016 4820.2730605 8.951909e-05 2.749574e-16 1.121659e-14 19 1105275 1105280 6 + 3.581 3.529 -0.175
ENSG00000167468 E017 42.4075585 3.204781e-03 2.428978e-05 1.478007e-04 19 1105281 1105365 85 + 1.716 1.442 -0.935
ENSG00000167468 E018 9920.6629746 1.333444e-04 6.562992e-07 5.670357e-06 19 1105366 1105453 88 + 3.869 3.848 -0.070
ENSG00000167468 E019 9744.4702812 1.220237e-04 1.509813e-04 7.514043e-04 19 1105454 1105510 57 + 3.855 3.842 -0.042
ENSG00000167468 E020 5683.3861560 2.492077e-04 3.949399e-04 1.755106e-03 19 1105658 1105664 7 + 3.627 3.606 -0.070
ENSG00000167468 E021 9280.9255389 4.820977e-05 1.975440e-05 1.226618e-04 19 1105665 1105725 61 + 3.832 3.820 -0.040
ENSG00000167468 E022 9694.5608023 3.587026e-04 4.542696e-03 1.466149e-02 19 1105726 1105809 84 + 3.807 3.849 0.137
ENSG00000167468 E023 29.5249084 7.886243e-03 2.629697e-07 2.462591e-06 19 1105810 1106180 371 + 1.660 1.255 -1.398
ENSG00000167468 E024 31.1069951 1.433651e-02 7.340337e-04 3.021806e-03 19 1106181 1106241 61 + 1.603 1.313 -1.000
ENSG00000167468 E025 5960.1202962 1.009409e-03 9.041929e-06 6.072195e-05 19 1106242 1106266 25 + 3.558 3.644 0.285
ENSG00000167468 E026 82.4182516 2.689422e-03 2.707150e-02 6.613642e-02 19 1106378 1106399 22 + 1.871 1.763 -0.367
ENSG00000167468 E027 7110.1534029 4.321798e-04 3.601519e-12 8.062117e-11 19 1106400 1106459 60 + 3.629 3.721 0.305
ENSG00000167468 E028 92.8369972 1.295565e-01 3.667454e-01 5.110860e-01 19 1106460 1106463 4 + 1.580 1.865 0.967
ENSG00000167468 E029 4144.6638152 2.976896e-04 6.551467e-08 6.897225e-07 19 1106540 1106546 7 + 3.409 3.483 0.245
ENSG00000167468 E030 5095.5636926 7.394922e-04 9.247562e-09 1.147598e-07 19 1106547 1106572 26 + 3.479 3.577 0.326
ENSG00000167468 E031 6450.2082810 5.837103e-04 1.488172e-10 2.549784e-09 19 1106573 1106853 281 + 3.583 3.679 0.320