ENSG00000167393

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000390665 ENSG00000167393 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R3B protein_coding protein_coding 31.21679 43.94363 21.59158 3.902193 0.4831771 -1.024845 4.828330 5.511393 4.619432 0.4299129 0.3749002 -0.25419683 0.15576250 0.12653333 0.21360000 0.08706667 4.430966e-03 3.700691e-14 FALSE TRUE
ENST00000468169 ENSG00000167393 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R3B protein_coding retained_intron 31.21679 43.94363 21.59158 3.902193 0.4831771 -1.024845 4.907000 4.536801 4.285890 0.4684897 0.7773161 -0.08189467 0.17178750 0.10360000 0.19976667 0.09616667 1.190493e-01 3.700691e-14 FALSE TRUE
ENST00000496630 ENSG00000167393 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R3B protein_coding retained_intron 31.21679 43.94363 21.59158 3.902193 0.4831771 -1.024845 1.871692 1.876939 1.473354 0.4748666 1.0091687 -0.34718469 0.06439167 0.04243333 0.06666667 0.02423333 9.548068e-01 3.700691e-14 FALSE FALSE
MSTRG.33834.7 ENSG00000167393 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R3B protein_coding   31.21679 43.94363 21.59158 3.902193 0.4831771 -1.024845 14.504629 27.334924 6.754540 2.6335916 0.3833597 -2.01520939 0.42989167 0.62143333 0.31370000 -0.30773333 3.700691e-14 3.700691e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167393 E001 15.2443880 0.0012067003 9.247939e-01 9.566421e-01 X 328046 328085 40 - 1.158 1.145 -0.046
ENSG00000167393 E002 8.6107423 0.0042215822 2.548198e-03 8.907126e-03 X 333550 333595 46 - 1.158 0.816 -1.270
ENSG00000167393 E003 21.9431314 0.0026505681 5.322607e-05 2.978707e-04 X 333596 333932 337 - 1.511 1.194 -1.103
ENSG00000167393 E004 24.6335232 0.0008059387 1.393258e-03 5.284906e-03 X 333933 334234 302 - 1.511 1.276 -0.811
ENSG00000167393 E005 8.5360735 0.0022122733 4.817671e-01 6.199604e-01 X 334235 334236 2 - 0.989 0.903 -0.323
ENSG00000167393 E006 8.2405313 0.0027192652 5.574471e-01 6.858512e-01 X 334237 334238 2 - 0.965 0.891 -0.279
ENSG00000167393 E007 9.9378968 0.0017894178 8.607036e-01 9.141519e-01 X 334239 334240 2 - 0.989 0.966 -0.087
ENSG00000167393 E008 221.7214702 0.0002139075 5.796808e-06 4.066459e-05 X 334241 334517 277 - 2.181 2.305 0.415
ENSG00000167393 E009 141.5704519 0.0002702808 1.778339e-10 3.006165e-09 X 334518 338603 4086 - 2.230 2.025 -0.685
ENSG00000167393 E010 125.4060817 0.0002670477 4.867697e-06 3.475823e-05 X 338604 338612 9 - 1.899 2.069 0.572
ENSG00000167393 E011 252.6989312 0.0002187216 3.413323e-07 3.122224e-06 X 338613 338710 98 - 2.234 2.365 0.438
ENSG00000167393 E012 16.0254789 0.0429244662 1.035683e-01 1.959367e-01 X 338711 338777 67 - 1.325 1.101 -0.792
ENSG00000167393 E013 294.6603835 0.0002505334 1.472817e-04 7.354069e-04 X 338778 338896 119 - 2.336 2.424 0.295
ENSG00000167393 E014 316.5011219 0.0003980770 2.745315e-01 4.136971e-01 X 340765 340940 176 - 2.417 2.440 0.076
ENSG00000167393 E015 270.4203767 0.0007995313 4.593822e-01 5.995491e-01 X 341307 341396 90 - 2.385 2.363 -0.074
ENSG00000167393 E016 18.9834471 0.0011103571 8.658424e-07 7.289630e-06 X 341397 341882 486 - 1.497 1.105 -1.373
ENSG00000167393 E017 187.9616896 0.0002589394 5.106678e-01 6.458631e-01 X 341883 341910 28 - 2.226 2.203 -0.076
ENSG00000167393 E018 173.1394476 0.0028942582 5.910140e-01 7.138220e-01 X 341911 341931 21 - 2.190 2.168 -0.072
ENSG00000167393 E019 5.5670244 0.0121203060 8.954380e-02 1.744260e-01 X 341932 342237 306 - 0.914 0.674 -0.953
ENSG00000167393 E020 13.9599329 0.0012479657 2.105564e-01 3.392031e-01 X 344896 345515 620 - 1.011 1.139 0.462
ENSG00000167393 E021 327.4107523 0.0001988813 6.353002e-01 7.496324e-01 X 345516 345672 157 - 2.442 2.448 0.023
ENSG00000167393 E022 200.5959923 0.0010627644 4.465440e-01 5.880346e-01 X 346174 346260 87 - 2.219 2.241 0.072
ENSG00000167393 E023 10.3224908 0.0016924313 1.126960e-02 3.180669e-02 X 346261 346514 254 - 1.173 0.903 -0.989
ENSG00000167393 E024 4.5297271 0.0036292397 1.886918e-01 3.120923e-01 X 346637 346700 64 - 0.824 0.633 -0.782
ENSG00000167393 E025 139.9538470 0.0002781948 7.978558e-01 8.710038e-01 X 346701 346719 19 - 2.079 2.084 0.016
ENSG00000167393 E026 165.7642407 0.0002294877 8.480203e-01 9.056439e-01 X 346720 346775 56 - 2.154 2.156 0.007
ENSG00000167393 E027 204.9628132 0.0006345635 8.583119e-01 9.125729e-01 X 347234 347336 103 - 2.244 2.246 0.007
ENSG00000167393 E028 130.6726647 0.0010966290 2.577888e-01 3.949610e-01 X 347590 347610 21 - 2.019 2.059 0.135
ENSG00000167393 E029 172.0983607 0.0002033220 4.747675e-01 6.135787e-01 X 347611 347693 83 - 2.157 2.175 0.060
ENSG00000167393 E030 0.2998086 0.0297367776 5.066717e-01   X 347694 347838 145 - 0.180 0.081 -1.326
ENSG00000167393 E031 222.0480392 0.0003209421 1.183387e-01 2.175579e-01 X 361405 361590 186 - 2.316 2.270 -0.152
ENSG00000167393 E032 2.0878613 0.1617054044 3.403823e-02 7.983262e-02 X 362255 362332 78 - 0.749 0.263 -2.468
ENSG00000167393 E033 8.4669436 0.0222204789 3.559320e-01 5.003018e-01 X 373532 374044 513 - 0.823 0.954 0.497
ENSG00000167393 E034 0.9588613 0.0209695853 5.974572e-02 1.261882e-01 X 385042 385091 50 - 0.486 0.150 -2.322
ENSG00000167393 E035 107.7878546 0.0037486190 4.123795e-10 6.561187e-09 X 386368 386955 588 - 2.166 1.882 -0.954
ENSG00000167393 E036 11.8051688 0.0067990362 2.118592e-01 3.406907e-01 X 387106 387183 78 - 1.142 1.003 -0.503