ENSG00000167380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300823 ENSG00000167380 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF226 protein_coding protein_coding 4.644775 3.329456 6.839698 0.5380467 0.1393919 1.036427 1.52718045 1.5330634 3.0105708 0.7606964 0.43341003 0.9690239 0.30902083 0.42053333 0.4385000 0.01796667 9.820567e-01 1.789572e-05    
ENST00000337433 ENSG00000167380 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF226 protein_coding protein_coding 4.644775 3.329456 6.839698 0.5380467 0.1393919 1.036427 0.28273626 0.0000000 0.0000000 0.0000000 0.00000000 0.0000000 0.08047500 0.00000000 0.0000000 0.00000000   1.789572e-05 FALSE  
ENST00000413984 ENSG00000167380 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF226 protein_coding protein_coding 4.644775 3.329456 6.839698 0.5380467 0.1393919 1.036427 0.28359561 0.1436805 0.0000000 0.1436805 0.00000000 -3.9418622 0.06596250 0.05676667 0.0000000 -0.05676667 6.916599e-01 1.789572e-05    
ENST00000585560 ENSG00000167380 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF226 protein_coding protein_coding 4.644775 3.329456 6.839698 0.5380467 0.1393919 1.036427 0.15773654 0.0000000 0.4479495 0.0000000 0.04939757 5.5171165 0.02762083 0.00000000 0.0656000 0.06560000 1.789572e-05 1.789572e-05    
ENST00000590578 ENSG00000167380 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF226 protein_coding protein_coding 4.644775 3.329456 6.839698 0.5380467 0.1393919 1.036427 0.83688226 0.2799077 1.9521459 0.2008933 0.03586668 2.7587667 0.16985417 0.08493333 0.2854333 0.20050000 1.311407e-01 1.789572e-05 FALSE  
MSTRG.17278.18 ENSG00000167380 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF226 protein_coding   4.644775 3.329456 6.839698 0.5380467 0.1393919 1.036427 0.09111198 0.3280337 0.0000000 0.3280337 0.00000000 -5.0790954 0.02323333 0.10570000 0.0000000 -0.10570000 7.102952e-01 1.789572e-05    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167380 E001 0.1472490 0.0428552265 0.836272698   19 44165073 44165083 11 + 0.098 0.000 -8.741
ENSG00000167380 E002 0.3686942 0.0273996656 0.686757317 0.78920332 19 44165084 44165096 13 + 0.098 0.152 0.717
ENSG00000167380 E003 0.9651910 0.0131629568 0.862140069 0.91511888 19 44165097 44165099 3 + 0.305 0.263 -0.286
ENSG00000167380 E004 1.7036261 0.0079882645 0.181836880 0.30352931 19 44165100 44165100 1 + 0.517 0.263 -1.456
ENSG00000167380 E005 1.7036261 0.0079882645 0.181836880 0.30352931 19 44165101 44165102 2 + 0.517 0.263 -1.456
ENSG00000167380 E006 1.7036261 0.0079882645 0.181836880 0.30352931 19 44165103 44165103 1 + 0.517 0.263 -1.456
ENSG00000167380 E007 1.8853305 0.0078588381 0.391134756 0.53507175 19 44165104 44165106 3 + 0.517 0.352 -0.871
ENSG00000167380 E008 1.8853305 0.0078588381 0.391134756 0.53507175 19 44165107 44165108 2 + 0.517 0.352 -0.871
ENSG00000167380 E009 2.0325795 0.0074426073 0.295817535 0.43696245 19 44165109 44165111 3 + 0.549 0.352 -1.023
ENSG00000167380 E010 3.1148437 0.0399244123 0.148029010 0.25898959 19 44165112 44165115 4 + 0.705 0.426 -1.285
ENSG00000167380 E011 11.1363402 0.0087069475 0.867690467 0.91889336 19 44165116 44165142 27 + 1.086 1.087 0.004
ENSG00000167380 E012 1.2479590 0.0123827335 0.147684245 0.25854398 19 44165143 44165154 12 + 0.246 0.489 1.448
ENSG00000167380 E013 1.3952081 0.0428100873 0.286232309 0.42663257 19 44165155 44165163 9 + 0.304 0.487 1.028
ENSG00000167380 E014 2.8249707 0.0070552573 0.005295279 0.01673576 19 44165164 44165188 25 + 0.356 0.778 1.976
ENSG00000167380 E015 1.9186374 0.0079699179 0.016470061 0.04377390 19 44165189 44165246 58 + 0.246 0.637 2.130
ENSG00000167380 E016 3.6920941 0.0313060307 0.542096210 0.67292661 19 44165588 44165613 26 + 0.634 0.713 0.333
ENSG00000167380 E017 3.6116675 0.0267212028 0.419462447 0.56272193 19 44165614 44165755 142 + 0.607 0.714 0.454
ENSG00000167380 E018 1.6490203 0.1748414846 0.429973675 0.57259803 19 44165756 44165756 1 + 0.356 0.491 0.726
ENSG00000167380 E019 18.2158523 0.0010802977 0.890027889 0.93372968 19 44165757 44165807 51 + 1.285 1.277 -0.030
ENSG00000167380 E020 2.1682004 0.0229261327 0.543486071 0.67409666 19 44166705 44166882 178 + 0.549 0.426 -0.608
ENSG00000167380 E021 0.5879639 0.0200206594 0.627627572 0.74341264 19 44167819 44167860 42 + 0.246 0.151 -0.872
ENSG00000167380 E022 0.7490443 0.1047551061 0.084152783 0.16605379 19 44169565 44169628 64 + 0.357 0.000 -12.921
ENSG00000167380 E023 2.1713208 0.0227623614 0.941456837 0.96719555 19 44170033 44170034 2 + 0.517 0.489 -0.136
ENSG00000167380 E024 11.2938090 0.0017602558 0.484216129 0.62222889 19 44170035 44170039 5 + 1.129 1.041 -0.317
ENSG00000167380 E025 23.4200898 0.0009692376 0.585731866 0.70937788 19 44170040 44170095 56 + 1.382 1.401 0.063
ENSG00000167380 E026 17.4864143 0.0011293821 0.413249539 0.55676056 19 44172088 44172091 4 + 1.250 1.295 0.160
ENSG00000167380 E027 48.5518225 0.0026055072 0.343385877 0.48742978 19 44172092 44172214 123 + 1.684 1.713 0.100
ENSG00000167380 E028 2.4409379 0.0064516380 0.198470377 0.32429958 19 44172215 44172758 544 + 0.444 0.637 0.906
ENSG00000167380 E029 41.9030441 0.0132535113 0.394666448 0.53850634 19 44172860 44172952 93 + 1.614 1.652 0.126
ENSG00000167380 E030 10.2550760 0.0526902343 0.584759825 0.70860381 19 44172953 44174983 2031 + 1.086 0.975 -0.406
ENSG00000167380 E031 30.9853374 0.0039920144 0.041412627 0.09364740 19 44174984 44175497 514 + 1.454 1.569 0.396
ENSG00000167380 E032 123.9601253 0.0130925136 0.086198034 0.16931536 19 44175498 44178381 2884 + 2.136 2.023 -0.379