ENSG00000167302

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300714 ENSG00000167302 HEK293_OSMI2_2hA HEK293_TMG_2hB TEPSIN protein_coding protein_coding 20.58063 25.38841 15.62761 1.992724 0.8704876 -0.6997184 9.427174 12.550888 6.6271212 0.6915374 0.2335009 -0.920309 0.4545917 0.49636667 0.42620000 -0.07016667 2.453899e-01 6.098292e-08 FALSE TRUE
ENST00000575891 ENSG00000167302 HEK293_OSMI2_2hA HEK293_TMG_2hB TEPSIN protein_coding processed_transcript 20.58063 25.38841 15.62761 1.992724 0.8704876 -0.6997184 1.692402 1.386151 3.3252023 0.6969055 0.3807090 1.256319 0.0870500 0.05066667 0.21143333 0.16076667 3.829670e-01 6.098292e-08 FALSE FALSE
ENST00000576090 ENSG00000167302 HEK293_OSMI2_2hA HEK293_TMG_2hB TEPSIN protein_coding retained_intron 20.58063 25.38841 15.62761 1.992724 0.8704876 -0.6997184 2.746500 1.893775 2.6926999 0.1700042 0.2387744 0.505538 0.1436083 0.07443333 0.17203333 0.09760000 6.098292e-08 6.098292e-08 FALSE TRUE
ENST00000637944 ENSG00000167302 HEK293_OSMI2_2hA HEK293_TMG_2hB TEPSIN protein_coding protein_coding 20.58063 25.38841 15.62761 1.992724 0.8704876 -0.6997184 2.763663 5.971569 0.1498946 0.5200823 0.1498946 -5.225331 0.1167333 0.23576667 0.01066667 -0.22510000 5.881498e-03 6.098292e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167302 E001 2.433360 0.1057608068 1.694908e-01 2.875316e-01 17 81228277 81228278 2 - 0.282 0.595 1.686
ENSG00000167302 E002 514.300289 0.0053053360 2.967770e-04 1.366838e-03 17 81228279 81229256 978 - 2.570 2.709 0.463
ENSG00000167302 E003 112.674159 0.0051971505 2.351875e-01 3.685811e-01 17 81229257 81229476 220 - 1.955 2.033 0.264
ENSG00000167302 E004 119.828961 0.0003576175 2.111104e-01 3.398328e-01 17 81230544 81230678 135 - 1.994 2.054 0.198
ENSG00000167302 E005 93.212613 0.0003573960 3.363940e-02 7.904056e-02 17 81231398 81231476 79 - 1.859 1.959 0.337
ENSG00000167302 E006 19.206958 0.0121392084 7.324203e-01 8.238766e-01 17 81231477 81231493 17 - 1.285 1.268 -0.060
ENSG00000167302 E007 131.988623 0.0003480955 1.152870e-01 2.132764e-01 17 81231578 81231691 114 - 2.033 2.101 0.227
ENSG00000167302 E008 69.430267 0.0004013035 7.100416e-02 1.450049e-01 17 81231847 81231861 15 - 1.736 1.834 0.332
ENSG00000167302 E009 157.670757 0.0002470231 2.148297e-02 5.461025e-02 17 81231862 81232021 160 - 2.096 2.181 0.285
ENSG00000167302 E010 73.817903 0.0004119033 3.130578e-03 1.064983e-02 17 81232315 81232518 204 - 1.717 1.868 0.511
ENSG00000167302 E011 99.062800 0.0003931887 3.126243e-02 7.441447e-02 17 81233432 81233503 72 - 1.880 1.980 0.335
ENSG00000167302 E012 95.389565 0.0020618863 9.406723e-02 1.814870e-01 17 81233638 81233716 79 - 1.872 1.962 0.303
ENSG00000167302 E013 57.131861 0.0035142732 2.902188e-01 4.310044e-01 17 81233981 81233993 13 - 1.665 1.741 0.257
ENSG00000167302 E014 51.933405 0.0004987017 1.591197e-01 2.739325e-01 17 81233994 81234002 9 - 1.615 1.705 0.305
ENSG00000167302 E015 75.862570 0.0020982323 4.517073e-02 1.005069e-01 17 81234003 81234048 46 - 1.757 1.871 0.384
ENSG00000167302 E016 8.007885 0.0083704844 1.306353e-07 1.297770e-06 17 81234049 81234234 186 - 1.253 0.650 -2.283
ENSG00000167302 E017 4.131867 0.0058275950 2.273319e-04 1.080574e-03 17 81236659 81236707 49 - 0.965 0.456 -2.147
ENSG00000167302 E018 103.723053 0.0003687302 2.615743e-01 3.992272e-01 17 81236708 81236801 94 - 1.934 1.991 0.192
ENSG00000167302 E019 5.096138 0.0032831135 1.486792e-03 5.593684e-03 17 81236802 81236979 178 - 0.986 0.578 -1.640
ENSG00000167302 E020 99.838773 0.0021278545 4.416440e-01 5.832852e-01 17 81236980 81237071 92 - 1.923 1.972 0.167
ENSG00000167302 E021 34.260893 0.0032954282 1.381890e-07 1.367076e-06 17 81237072 81237386 315 - 1.706 1.381 -1.112
ENSG00000167302 E022 95.241067 0.0034369019 3.240106e-01 4.673654e-01 17 81237387 81237459 73 - 1.959 1.930 -0.096
ENSG00000167302 E023 18.962274 0.0012947981 2.572975e-08 2.936400e-07 17 81237460 81237550 91 - 1.512 1.092 -1.472
ENSG00000167302 E024 20.402497 0.0009921681 1.646618e-09 2.344760e-08 17 81237551 81237623 73 - 1.553 1.116 -1.526
ENSG00000167302 E025 20.073430 0.0029804934 6.913328e-09 8.779389e-08 17 81237624 81237660 37 - 1.547 1.108 -1.535
ENSG00000167302 E026 57.067421 0.0004318572 1.589581e-12 3.766620e-11 17 81237661 81238132 472 - 1.915 1.599 -1.069
ENSG00000167302 E027 16.034624 0.0011640903 2.635064e-07 2.466794e-06 17 81238133 81238159 27 - 1.439 1.022 -1.478
ENSG00000167302 E028 16.571396 0.0011267574 2.394958e-09 3.310841e-08 17 81238160 81238211 52 - 1.480 1.002 -1.692
ENSG00000167302 E029 24.854239 0.0148664463 8.421833e-06 5.690865e-05 17 81238212 81238513 302 - 1.610 1.223 -1.336
ENSG00000167302 E030 37.630523 0.0080636242 4.223149e-09 5.572244e-08 17 81238514 81238873 360 - 1.781 1.383 -1.360
ENSG00000167302 E031 20.056239 0.0168862549 6.028351e-08 6.388750e-07 17 81238874 81238985 112 - 1.564 1.056 -1.780
ENSG00000167302 E032 68.916825 0.0014869815 4.198603e-01 5.631121e-01 17 81238986 81239091 106 - 1.815 1.792 -0.079