ENSG00000167280

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000577783 ENSG00000167280 HEK293_OSMI2_2hA HEK293_TMG_2hB ENGASE protein_coding retained_intron 25.68983 26.97792 17.09 3.175807 1.29062 -0.6583176 2.009300 0.9073341 1.8805898 0.5116884 0.34317910 1.0433171 0.08497083 0.03020000 0.11396667 0.08376667 9.359513e-02 2.123642e-07 FALSE FALSE
ENST00000579016 ENSG00000167280 HEK293_OSMI2_2hA HEK293_TMG_2hB ENGASE protein_coding protein_coding 25.68983 26.97792 17.09 3.175807 1.29062 -0.6583176 10.318616 13.4926573 6.5172685 0.6525329 0.59115145 -1.0486921 0.40300833 0.50860000 0.38263333 -0.12596667 1.527603e-01 2.123642e-07 FALSE TRUE
ENST00000579809 ENSG00000167280 HEK293_OSMI2_2hA HEK293_TMG_2hB ENGASE protein_coding retained_intron 25.68983 26.97792 17.09 3.175807 1.29062 -0.6583176 2.204654 2.1490190 1.6569127 0.5388452 0.11706948 -0.3731974 0.08580000 0.07733333 0.09826667 0.02093333 6.095926e-01 2.123642e-07 FALSE TRUE
ENST00000585160 ENSG00000167280 HEK293_OSMI2_2hA HEK293_TMG_2hB ENGASE protein_coding processed_transcript 25.68983 26.97792 17.09 3.175807 1.29062 -0.6583176 5.641389 3.6546413 3.9868129 0.7718960 1.39128504 0.1251780 0.21421667 0.13333333 0.22446667 0.09113333 3.964090e-01 2.123642e-07   FALSE
MSTRG.15202.7 ENSG00000167280 HEK293_OSMI2_2hA HEK293_TMG_2hB ENGASE protein_coding   25.68983 26.97792 17.09 3.175807 1.29062 -0.6583176 1.697077 3.4246937 0.1079332 0.8036592 0.05604815 -4.8641393 0.05995417 0.12416667 0.00680000 -0.11736667 2.123642e-07 2.123642e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167280 E001 0.1817044 0.0394384490 1.000000e+00   17 79074824 79074830 7 + 0.001 0.082 7.199
ENSG00000167280 E002 1.7963962 0.3217080635 1.408649e-01 2.492126e-01 17 79074831 79074856 26 + 0.610 0.311 -1.556
ENSG00000167280 E003 2.7499589 0.2567087342 1.152756e-01 2.132615e-01 17 79074857 79074919 63 + 0.749 0.424 -1.475
ENSG00000167280 E004 2.0877857 0.2185279972 1.474302e-01 2.581970e-01 17 79074920 79074922 3 + 0.661 0.350 -1.530
ENSG00000167280 E005 2.4167391 0.2179039180 1.238121e-01 2.253938e-01 17 79074923 79074924 2 + 0.707 0.389 -1.498
ENSG00000167280 E006 2.5619118 0.2407817579 9.827677e-02 1.879093e-01 17 79074925 79074933 9 + 0.748 0.389 -1.667
ENSG00000167280 E007 2.8908652 0.2608663879 9.110895e-02 1.768711e-01 17 79074934 79074934 1 + 0.786 0.424 -1.624
ENSG00000167280 E008 3.8549103 0.0340795355 2.015491e-02 5.180922e-02 17 79074935 79074937 3 + 0.884 0.515 -1.550
ENSG00000167280 E009 45.5995869 0.0254636073 8.622388e-05 4.573412e-04 17 79074938 79075090 153 + 1.839 1.484 -1.208
ENSG00000167280 E010 58.4904594 0.0095566388 2.221553e-03 7.910430e-03 17 79077430 79077497 68 + 1.849 1.647 -0.684
ENSG00000167280 E011 39.7684085 0.0164059044 9.840818e-02 1.880884e-01 17 79077663 79077666 4 + 1.648 1.505 -0.487
ENSG00000167280 E012 140.6844945 0.0002531251 4.283174e-06 3.093300e-05 17 79077667 79077864 198 + 2.189 2.042 -0.495
ENSG00000167280 E013 131.7693721 0.0012005904 3.077357e-01 4.499676e-01 17 79079489 79079637 149 + 2.084 2.047 -0.126
ENSG00000167280 E014 110.0213862 0.0057697181 6.704390e-01 7.768833e-01 17 79080207 79080311 105 + 1.995 1.976 -0.063
ENSG00000167280 E015 78.8909516 0.0026896919 1.512297e-01 2.633492e-01 17 79080312 79080364 53 + 1.888 1.818 -0.237
ENSG00000167280 E016 125.3643127 0.0002577221 5.334121e-02 1.150952e-01 17 79080925 79081019 95 + 2.084 2.016 -0.227
ENSG00000167280 E017 111.6353144 0.0003055037 1.885481e-02 4.901594e-02 17 79081020 79081073 54 + 2.048 1.961 -0.291
ENSG00000167280 E018 162.8816896 0.0011537702 1.855848e-01 3.082337e-01 17 79081898 79082028 131 + 2.178 2.133 -0.148
ENSG00000167280 E019 101.9296925 0.0036801051 6.203611e-01 7.375530e-01 17 79082029 79082063 35 + 1.922 1.949 0.093
ENSG00000167280 E020 21.0118257 0.0134700448 2.348955e-06 1.799242e-05 17 79082064 79082877 814 + 1.561 1.128 -1.511
ENSG00000167280 E021 117.9596373 0.0080515010 3.735505e-01 5.179784e-01 17 79083020 79083085 66 + 1.962 2.022 0.202
ENSG00000167280 E022 105.7694604 0.0044276217 4.745992e-01 6.134156e-01 17 79083086 79083123 38 + 1.929 1.970 0.135
ENSG00000167280 E023 2.6280572 0.0218871637 7.381368e-04 3.036190e-03 17 79083301 79083481 181 + 0.854 0.308 -2.575
ENSG00000167280 E024 151.2851636 0.0063584520 5.529325e-01 6.821529e-01 17 79083482 79083590 109 + 2.088 2.125 0.125
ENSG00000167280 E025 127.2617753 0.0002743253 2.396415e-01 3.736850e-01 17 79083761 79083853 93 + 2.069 2.028 -0.140
ENSG00000167280 E026 108.7113203 0.0002672552 4.726851e-01 6.117389e-01 17 79083854 79083931 78 + 1.952 1.979 0.090
ENSG00000167280 E027 72.7909056 0.0003722515 4.654580e-01 6.051758e-01 17 79083932 79083951 20 + 1.777 1.811 0.113
ENSG00000167280 E028 15.2867390 0.0591879983 6.898481e-05 3.751569e-04 17 79083952 79084234 283 + 1.480 0.930 -1.961
ENSG00000167280 E029 18.7058139 0.0010207460 3.998111e-09 5.303018e-08 17 79084247 79084537 291 + 1.522 1.055 -1.641
ENSG00000167280 E030 74.5872792 0.0003646258 7.599909e-02 1.531111e-01 17 79084538 79084553 16 + 1.747 1.830 0.281
ENSG00000167280 E031 159.9981707 0.0002069628 8.149100e-02 1.618896e-01 17 79084554 79084686 133 + 2.097 2.152 0.185
ENSG00000167280 E032 115.8662250 0.0002774807 2.350613e-01 3.684261e-01 17 79085234 79085289 56 + 1.967 2.011 0.148
ENSG00000167280 E033 108.7371982 0.0003091158 4.111867e-02 9.310825e-02 17 79085290 79085342 53 + 1.913 1.993 0.267
ENSG00000167280 E034 127.3817408 0.0025638618 4.592546e-05 2.611333e-04 17 79085620 79085734 115 + 1.894 2.080 0.624
ENSG00000167280 E035 21.6026231 0.0093907410 1.131411e-05 7.424656e-05 17 79085735 79085850 116 + 1.535 1.156 -1.321
ENSG00000167280 E036 650.0535236 0.0002772686 3.786088e-07 3.429583e-06 17 79085933 79087183 1251 + 2.681 2.765 0.281
ENSG00000167280 E037 96.8163449 0.0029794374 9.610380e-02 1.845252e-01 17 79087184 79087307 124 + 1.865 1.945 0.270
ENSG00000167280 E038 81.2857124 0.0057591157 4.279921e-01 5.707977e-01 17 79087308 79087365 58 + 1.820 1.864 0.148
ENSG00000167280 E039 71.7835135 0.0004330539 7.252338e-01 8.185660e-01 17 79087366 79087445 80 + 1.810 1.792 -0.058
ENSG00000167280 E040 146.7914930 0.0089429271 5.086385e-01 6.440232e-01 17 79087446 79087750 305 + 2.133 2.100 -0.110
ENSG00000167280 E041 193.4503183 0.0123501713 4.151255e-01 5.585413e-01 17 79087751 79087984 234 + 2.184 2.240 0.187
ENSG00000167280 E042 264.4648859 0.0071243046 1.752840e-02 4.610143e-02 17 79087985 79088599 615 + 2.269 2.388 0.395
ENSG00000167280 E043 27.1114359 0.0295420515 2.931054e-01 4.341444e-01 17 79090867 79091135 269 + 1.473 1.356 -0.403
ENSG00000167280 E044 14.3665334 0.0272997520 8.789561e-01 9.262341e-01 17 79091666 79091863 198 + 1.107 1.134 0.097
ENSG00000167280 E045 6.2158551 0.0854341241 7.761164e-01 8.558427e-01 17 79091864 79091866 3 + 0.750 0.811 0.243
ENSG00000167280 E046 6.8048632 0.0465195959 9.810494e-01 9.921679e-01 17 79091867 79092351 485 + 0.822 0.835 0.048