ENSG00000167272

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357500 ENSG00000167272 HEK293_OSMI2_2hA HEK293_TMG_2hB POP5 protein_coding protein_coding 74.71028 108.2988 54.94501 17.11502 0.3010599 -0.9788282 6.313517 9.521435 5.129259 1.4768567 0.5206196 -0.89113317 0.08523333 0.08840000 0.09343333 0.005033333 0.920271903 0.001580923 FALSE TRUE
ENST00000539716 ENSG00000167272 HEK293_OSMI2_2hA HEK293_TMG_2hB POP5 protein_coding retained_intron 74.71028 108.2988 54.94501 17.11502 0.3010599 -0.9788282 6.440341 4.740810 5.253807 0.2264519 0.2771648 0.14793296 0.09476667 0.04586667 0.09566667 0.049800000 0.001580923 0.001580923 FALSE FALSE
ENST00000541834 ENSG00000167272 HEK293_OSMI2_2hA HEK293_TMG_2hB POP5 protein_coding retained_intron 74.71028 108.2988 54.94501 17.11502 0.3010599 -0.9788282 5.350639 4.227937 3.740488 1.2448169 0.1054209 -0.17628394 0.07767083 0.03820000 0.06806667 0.029866667 0.048422215 0.001580923 FALSE TRUE
ENST00000542568 ENSG00000167272 HEK293_OSMI2_2hA HEK293_TMG_2hB POP5 protein_coding retained_intron 74.71028 108.2988 54.94501 17.11502 0.3010599 -0.9788282 4.134751 5.444710 2.568416 1.2133788 0.2481496 -1.08101783 0.05812083 0.05133333 0.04676667 -0.004566667 0.953235228 0.001580923   FALSE
ENST00000542776 ENSG00000167272 HEK293_OSMI2_2hA HEK293_TMG_2hB POP5 protein_coding processed_transcript 74.71028 108.2988 54.94501 17.11502 0.3010599 -0.9788282 29.350357 42.240992 21.213476 11.4052213 0.6354473 -0.99332424 0.38545417 0.37490000 0.38600000 0.011100000 0.951703719 0.001580923 FALSE FALSE
MSTRG.8165.5 ENSG00000167272 HEK293_OSMI2_2hA HEK293_TMG_2hB POP5 protein_coding   74.71028 108.2988 54.94501 17.11502 0.3010599 -0.9788282 11.134235 22.935569 5.809909 1.6016815 0.8872350 -1.97914720 0.13909583 0.21886667 0.10583333 -0.113033333 0.013750485 0.001580923 FALSE FALSE
MSTRG.8165.7 ENSG00000167272 HEK293_OSMI2_2hA HEK293_TMG_2hB POP5 protein_coding   74.71028 108.2988 54.94501 17.11502 0.3010599 -0.9788282 6.317614 8.181770 7.837377 1.5375037 1.4578255 -0.06196475 0.08770417 0.07500000 0.14236667 0.067366667 0.061746253 0.001580923 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167272 E001 6.635193 0.0025933616 2.899520e-01 4.307138e-01 12 120578764 120579047 284 - 0.938 0.805 -0.514
ENSG00000167272 E002 215.414724 0.0002781278 2.348749e-02 5.875014e-02 12 120579048 120579153 106 - 2.242 2.302 0.202
ENSG00000167272 E003 414.443032 0.0011686887 3.458683e-03 1.160657e-02 12 120579154 120579241 88 - 2.516 2.582 0.219
ENSG00000167272 E004 575.606308 0.0018029945 3.296578e-04 1.499428e-03 12 120579242 120579351 110 - 2.644 2.725 0.269
ENSG00000167272 E005 340.246300 0.0016726404 1.375052e-02 3.765586e-02 12 120579352 120579368 17 - 2.432 2.495 0.211
ENSG00000167272 E006 417.029159 0.0004141117 8.734241e-04 3.521186e-03 12 120579369 120579412 44 - 2.522 2.588 0.219
ENSG00000167272 E007 25.902075 0.0160538257 7.157549e-01 8.116083e-01 12 120579413 120579513 101 - 1.408 1.364 -0.152
ENSG00000167272 E008 432.348972 0.0006638679 9.508783e-01 9.732619e-01 12 120579514 120579597 84 - 2.590 2.585 -0.019
ENSG00000167272 E009 40.067771 0.0150950916 1.713506e-01 2.899467e-01 12 120579598 120579651 54 - 1.648 1.521 -0.436
ENSG00000167272 E010 45.903420 0.0187818713 2.261960e-01 3.578444e-01 12 120579652 120579773 122 - 1.700 1.579 -0.413
ENSG00000167272 E011 452.948780 0.0014130043 3.179834e-05 1.880416e-04 12 120579774 120579923 150 - 2.679 2.574 -0.351
ENSG00000167272 E012 32.487710 0.0060684695 1.826971e-04 8.895477e-04 12 120579924 120580139 216 - 1.658 1.379 -0.958
ENSG00000167272 E013 53.487436 0.0086454064 1.800824e-08 2.116652e-07 12 120580596 120580995 400 - 1.929 1.546 -1.297
ENSG00000167272 E014 37.861052 0.0151233425 1.324511e-01 2.374899e-01 12 120580996 120581114 119 - 1.638 1.491 -0.502
ENSG00000167272 E015 460.950747 0.0056317171 1.853774e-01 3.079658e-01 12 120581115 120581257 143 - 2.657 2.585 -0.239
ENSG00000167272 E016 13.306928 0.0400344420 2.377224e-01 3.715059e-01 12 120581258 120581336 79 - 1.226 1.042 -0.662
ENSG00000167272 E017 224.858402 0.0060253858 1.900426e-01 3.138309e-01 12 120581343 120581412 70 - 2.353 2.273 -0.269