ENSG00000167257

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300650 ENSG00000167257 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF214 protein_coding protein_coding 10.59235 9.781222 10.51862 0.275823 0.0989144 0.104756 7.151543 8.1143246 7.1866676 0.6393138 0.3033571 -0.1749189 0.6875333 0.8287 0.68380000 -0.14490000 2.678206e-01 4.561681e-18 FALSE TRUE
ENST00000531452 ENSG00000167257 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF214 protein_coding protein_coding 10.59235 9.781222 10.51862 0.275823 0.0989144 0.104756 1.124294 0.8910247 0.3790392 0.5270852 0.3790392 -1.2116510 0.1035375 0.0911 0.03546667 -0.05563333 5.623811e-01 4.561681e-18 FALSE TRUE
ENST00000534428 ENSG00000167257 HEK293_OSMI2_2hA HEK293_TMG_2hB RNF214 protein_coding protein_coding 10.59235 9.781222 10.51862 0.275823 0.0989144 0.104756 1.114236 0.0000000 1.6400288 0.0000000 0.2038882 7.3663474 0.0930000 0.0000 0.15563333 0.15563333 4.561681e-18 4.561681e-18 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167257 E001 1.0674006 0.0120273624 4.686999e-01 6.080933e-01 11 117232625 117232670 46 + 0.396 0.267 -0.808
ENSG00000167257 E002 0.7341808 0.0415776922 4.627841e-01 6.026427e-01 11 117232671 117232683 13 + 0.326 0.195 -0.983
ENSG00000167257 E003 3.9072112 0.0047354391 1.003662e-01 1.910328e-01 11 117232684 117232702 19 + 0.819 0.584 -0.977
ENSG00000167257 E004 14.0854928 0.0013451458 1.671155e-02 4.430199e-02 11 117232703 117232726 24 + 1.293 1.082 -0.751
ENSG00000167257 E005 1.8926157 0.0299795973 6.508949e-01 7.618693e-01 11 117232736 117232775 40 + 0.510 0.431 -0.398
ENSG00000167257 E006 0.6674587 0.0269409009 2.094160e-01 3.378401e-01 11 117234263 117234266 4 + 0.326 0.109 -1.974
ENSG00000167257 E007 56.3556300 0.0004707499 1.591727e-04 7.881337e-04 11 117234267 117234379 113 + 1.847 1.670 -0.600
ENSG00000167257 E008 61.7974784 0.0022396882 9.574278e-04 3.813106e-03 11 117238601 117238646 46 + 1.878 1.713 -0.558
ENSG00000167257 E009 88.8770662 0.0022141747 3.110780e-03 1.059254e-02 11 117238647 117238801 155 + 2.016 1.888 -0.433
ENSG00000167257 E010 147.1959140 0.0048498929 3.361275e-02 7.899166e-02 11 117238802 117239111 310 + 2.215 2.121 -0.315
ENSG00000167257 E011 4.6744445 0.0036387686 5.626569e-07 4.929414e-06 11 117239112 117239800 689 + 1.044 0.330 -3.147
ENSG00000167257 E012 87.5333278 0.0053941648 1.127693e-02 3.182310e-02 11 117239801 117239860 60 + 2.013 1.881 -0.445
ENSG00000167257 E013 137.1134367 0.0016498829 2.108837e-02 5.378207e-02 11 117244445 117244585 141 + 2.178 2.095 -0.278
ENSG00000167257 E014 144.4738071 0.0004132427 6.928759e-01 7.939758e-01 11 117246809 117246948 140 + 2.162 2.148 -0.046
ENSG00000167257 E015 117.2715780 0.0049668983 4.688014e-02 1.036155e-01 11 117279908 117280004 97 + 2.007 2.098 0.305
ENSG00000167257 E016 97.7955552 0.0003333744 7.731564e-02 1.551826e-01 11 117280171 117280259 89 + 1.947 2.009 0.207
ENSG00000167257 E017 80.3278111 0.0003303154 3.375538e-02 7.926352e-02 11 117281314 117281404 91 + 1.847 1.930 0.279
ENSG00000167257 E018 0.2924217 0.0290785164 1.396369e-01   11 117281428 117281472 45 + 0.242 0.000 -11.138
ENSG00000167257 E019 81.7218767 0.0003757894 2.269226e-02 5.711412e-02 11 117281600 117281698 99 + 1.854 1.943 0.298
ENSG00000167257 E020 0.5451131 0.7096103662 3.781050e-01 5.223954e-01 11 117281788 117281893 106 + 0.000 0.270 10.684
ENSG00000167257 E021 46.0708144 0.0095196335 3.640545e-01 5.084637e-01 11 117281894 117281911 18 + 1.627 1.689 0.210
ENSG00000167257 E022 55.6219040 0.0006850666 5.261382e-01 6.594113e-01 11 117281912 117281965 54 + 1.729 1.757 0.097
ENSG00000167257 E023 102.2641800 0.0021913028 8.903497e-02 1.736545e-01 11 117281966 117282164 199 + 1.964 2.032 0.229
ENSG00000167257 E024 54.9210769 0.0083505852 1.379241e-01 2.451890e-01 11 117282165 117282215 51 + 1.678 1.771 0.316
ENSG00000167257 E025 58.3283463 0.0056639881 7.283350e-01 8.208164e-01 11 117282216 117282270 55 + 1.753 1.771 0.062
ENSG00000167257 E026 99.0901421 0.0012542379 9.516213e-01 9.737015e-01 11 117282404 117282536 133 + 1.991 1.991 0.002
ENSG00000167257 E027 89.1305892 0.0003588079 7.186035e-02 1.464377e-01 11 117282746 117282850 105 + 1.901 1.967 0.223
ENSG00000167257 E028 103.0707056 0.0047436450 1.459212e-01 2.561250e-01 11 117283115 117283210 96 + 1.964 2.028 0.216
ENSG00000167257 E029 225.2693692 0.0002974577 8.070591e-04 3.283684e-03 11 117285086 117286454 1369 + 2.295 2.372 0.259