ENSG00000167232

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300619 ENSG00000167232 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF91 protein_coding protein_coding 1.497935 0.4611256 2.486445 0.1248631 0.2484677 2.405692 0.46557959 0.15869578 0.6060733 0.02790457 0.12835167 1.8686781 0.31721667 0.38166667 0.25126667 -0.1304000 0.680973881 0.002981379 FALSE TRUE
ENST00000397082 ENSG00000167232 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF91 protein_coding protein_coding 1.497935 0.4611256 2.486445 0.1248631 0.2484677 2.405692 0.25772339 0.00000000 0.5525897 0.00000000 0.16865225 5.8140113 0.11755417 0.00000000 0.21510000 0.2151000 0.008516523 0.002981379 FALSE TRUE
ENST00000593341 ENSG00000167232 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF91 protein_coding processed_transcript 1.497935 0.4611256 2.486445 0.1248631 0.2484677 2.405692 0.18363701 0.00000000 0.5703717 0.00000000 0.37929983 5.8589053 0.10410417 0.00000000 0.22170000 0.2217000 0.511135729 0.002981379   FALSE
ENST00000596989 ENSG00000167232 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF91 protein_coding processed_transcript 1.497935 0.4611256 2.486445 0.1248631 0.2484677 2.405692 0.01188825 0.09510597 0.0000000 0.09510597 0.00000000 -3.3937727 0.01687500 0.13500000 0.00000000 -0.1350000 0.375056510 0.002981379 FALSE FALSE
ENST00000597458 ENSG00000167232 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF91 protein_coding retained_intron 1.497935 0.4611256 2.486445 0.1248631 0.2484677 2.405692 0.20193237 0.17205913 0.1421260 0.03807147 0.05341092 -0.2591399 0.21020417 0.41890000 0.05576667 -0.3631333 0.002981379 0.002981379   FALSE
ENST00000599281 ENSG00000167232 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF91 protein_coding processed_transcript 1.497935 0.4611256 2.486445 0.1248631 0.2484677 2.405692 0.12041800 0.01765099 0.1348411 0.01765099 0.06798744 2.3890683 0.07340417 0.02506667 0.05996667 0.0349000 0.867971905 0.002981379   FALSE
ENST00000599743 ENSG00000167232 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF91 protein_coding protein_coding 1.497935 0.4611256 2.486445 0.1248631 0.2484677 2.405692 0.17717561 0.00000000 0.3052546 0.00000000 0.17225817 4.9784454 0.10460833 0.00000000 0.12900000 0.1290000 0.564303605 0.002981379 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167232 E001 0.0000000       19 23304991 23304998 8 -      
ENSG00000167232 E002 0.1451727 0.043375592 1.000000e+00   19 23304999 23305131 133 - 0.065 0.000 -8.121
ENSG00000167232 E003 0.1451727 0.043375592 1.000000e+00   19 23306809 23307315 507 - 0.065 0.000 -10.381
ENSG00000167232 E004 0.0000000       19 23307316 23307402 87 -      
ENSG00000167232 E005 0.8920389 0.015054886 4.662958e-01 6.058663e-01 19 23307403 23308743 1341 - 0.217 0.362 1.006
ENSG00000167232 E006 0.2955422 0.030352039 3.216660e-01   19 23308744 23308902 159 - 0.065 0.218 2.006
ENSG00000167232 E007 0.1482932 0.042030913 1.104275e-01   19 23308903 23308923 21 - 0.000 0.218 12.587
ENSG00000167232 E008 0.5149111 0.021768165 8.403909e-02 1.658623e-01 19 23308924 23309097 174 - 0.065 0.363 3.010
ENSG00000167232 E009 0.0000000       19 23310548 23310622 75 -      
ENSG00000167232 E010 3.7308253 0.004557949 1.160724e-07 1.165566e-06 19 23337831 23338748 918 - 0.295 1.059 3.423
ENSG00000167232 E011 2.3991077 0.007095311 5.123790e-03 1.626595e-02 19 23338749 23338852 104 - 0.329 0.794 2.200
ENSG00000167232 E012 1.7766884 0.009034542 1.347662e-02 3.702674e-02 19 23338853 23338875 23 - 0.258 0.691 2.271
ENSG00000167232 E013 1.7766884 0.009034542 1.347662e-02 3.702674e-02 19 23338876 23338887 12 - 0.258 0.691 2.271
ENSG00000167232 E014 3.8918977 0.006094034 7.324907e-02 1.487174e-01 19 23338888 23339054 167 - 0.556 0.837 1.177
ENSG00000167232 E015 1.1049644 0.205533312 2.388992e-01 3.728466e-01 19 23339055 23339230 176 - 0.217 0.469 1.585
ENSG00000167232 E016 0.6234514 0.585261968 7.072303e-01 8.052036e-01 19 23339231 23339260 30 - 0.172 0.219 0.435
ENSG00000167232 E017 3.2653374 0.144981332 1.013118e-01 1.924711e-01 19 23339261 23340137 877 - 0.471 0.797 1.428
ENSG00000167232 E018 1.7005031 0.009592884 1.610247e-01 2.764564e-01 19 23342170 23342265 96 - 0.295 0.558 1.426
ENSG00000167232 E019 0.8836053 0.015442508 5.573684e-02 1.192425e-01 19 23342266 23342269 4 - 0.122 0.471 2.596
ENSG00000167232 E020 4.1871604 0.050693545 2.334698e-02 5.847146e-02 19 23357696 23358429 734 - 0.535 0.913 1.566
ENSG00000167232 E021 9.0311992 0.002696158 2.334643e-03 8.258786e-03 19 23358430 23358729 300 - 1.004 0.558 -1.798
ENSG00000167232 E022 13.9499134 0.001779184 1.964674e-01 3.218067e-01 19 23358730 23359402 673 - 1.130 1.006 -0.450
ENSG00000167232 E023 38.3976756 0.004059470 1.847970e-03 6.752153e-03 19 23359403 23362124 2722 - 1.557 1.366 -0.655
ENSG00000167232 E024 11.5705895 0.001552648 8.051801e-05 4.303782e-04 19 23362125 23362725 601 - 1.109 0.558 -2.181
ENSG00000167232 E025 5.5470499 0.068374991 4.191682e-01 5.624187e-01 19 23373742 23373837 96 - 0.779 0.633 -0.604
ENSG00000167232 E026 6.0672715 0.026344789 9.795058e-01 9.912325e-01 19 23374638 23374764 127 - 0.780 0.795 0.061
ENSG00000167232 E027 4.7408750 0.018887311 2.978200e-01 4.391910e-01 19 23395325 23395471 147 - 0.730 0.558 -0.742