ENSG00000167193

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300574 ENSG00000167193 HEK293_OSMI2_2hA HEK293_TMG_2hB CRK protein_coding protein_coding 26.15781 13.61139 42.50926 2.428072 0.6138562 1.642242 13.28241 5.699098 21.51677 0.9501599 0.3012834 1.914797 0.4947875 0.4209667 0.5062667 0.0853 0.022509654 0.005604223 FALSE TRUE
ENST00000398970 ENSG00000167193 HEK293_OSMI2_2hA HEK293_TMG_2hB CRK protein_coding protein_coding 26.15781 13.61139 42.50926 2.428072 0.6138562 1.642242 12.61869 7.912292 20.25767 1.4994645 0.2716667 1.355190 0.4956583 0.5790333 0.4767333 -0.1023 0.005604223 0.005604223 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167193 E001 0.0000000       17 1420689 1420692 4 -      
ENSG00000167193 E002 1016.8632886 0.0041787291 5.172161e-16 2.028694e-14 17 1420693 1422225 1533 - 2.873 3.129 0.853
ENSG00000167193 E003 751.4313067 0.0001235979 3.060475e-02 7.315599e-02 17 1422226 1423185 960 - 2.802 2.899 0.322
ENSG00000167193 E004 320.3745853 0.0001964824 7.257802e-03 2.189571e-02 17 1423186 1423396 211 - 2.457 2.466 0.030
ENSG00000167193 E005 371.8353798 0.0011435639 3.382702e-07 3.096906e-06 17 1423397 1423650 254 - 2.540 2.473 -0.223
ENSG00000167193 E006 144.2684860 0.0002603257 5.466305e-08 5.842455e-07 17 1436620 1436789 170 - 2.144 2.024 -0.401
ENSG00000167193 E007 318.0404060 0.0010678120 1.150428e-15 4.308066e-14 17 1436790 1436997 208 - 2.493 2.337 -0.518
ENSG00000167193 E008 217.7402129 0.0001698004 1.648662e-17 7.851534e-16 17 1436998 1437155 158 - 2.333 2.160 -0.581
ENSG00000167193 E009 161.5447810 0.0025952224 7.210844e-14 2.091034e-12 17 1455877 1456232 356 - 2.218 1.962 -0.860
ENSG00000167193 E010 0.1817044 0.0495850550 1.648179e-01   17 1462953 1463162 210 - 0.000 0.200 10.099