ENSG00000167191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300571 ENSG00000167191 HEK293_OSMI2_2hA HEK293_TMG_2hB GPRC5B protein_coding protein_coding 7.746544 7.994945 8.371378 0.3963451 0.2233906 0.06629596 2.1142024 2.031095 2.5565508 0.03333214 0.01639235 0.3304876 0.2717458 0.2549333 0.30593333 0.0510000 0.3708527886 0.0003512882 FALSE TRUE
ENST00000562348 ENSG00000167191 HEK293_OSMI2_2hA HEK293_TMG_2hB GPRC5B protein_coding retained_intron 7.746544 7.994945 8.371378 0.3963451 0.2233906 0.06629596 0.9372794 1.534464 0.3607154 0.49735414 0.36071539 -2.0587221 0.1239708 0.1881667 0.04203333 -0.1461333 0.1470015453 0.0003512882 FALSE FALSE
ENST00000569479 ENSG00000167191 HEK293_OSMI2_2hA HEK293_TMG_2hB GPRC5B protein_coding protein_coding 7.746544 7.994945 8.371378 0.3963451 0.2233906 0.06629596 1.9581743 2.284400 0.7917432 0.21121520 0.47136392 -1.5169051 0.2615125 0.2892000 0.09446667 -0.1947333 0.3779002748 0.0003512882 FALSE TRUE
MSTRG.12214.3 ENSG00000167191 HEK293_OSMI2_2hA HEK293_TMG_2hB GPRC5B protein_coding   7.746544 7.994945 8.371378 0.3963451 0.2233906 0.06629596 2.6433564 2.042924 4.3977425 0.31891968 0.19277509 1.1023596 0.3316500 0.2551333 0.52640000 0.2712667 0.0003512882 0.0003512882 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167191 E001 6.7296662 0.0071768406 5.507578e-01 6.803389e-01 16 19856691 19857298 608 - 0.843 0.925 0.312
ENSG00000167191 E002 29.9683557 0.0013527197 5.502345e-01 6.798783e-01 16 19857299 19857743 445 - 1.471 1.518 0.162
ENSG00000167191 E003 31.8750519 0.0221352237 5.592835e-01 6.874097e-01 16 19857744 19857953 210 - 1.535 1.497 -0.132
ENSG00000167191 E004 26.2324920 0.0507507144 5.622162e-01 6.898774e-01 16 19857954 19858000 47 - 1.453 1.410 -0.147
ENSG00000167191 E005 52.1223748 0.0104031417 9.666474e-01 9.830816e-01 16 19858001 19858267 267 - 1.718 1.727 0.032
ENSG00000167191 E006 42.8512668 0.0005761365 9.794223e-01 9.911764e-01 16 19858268 19858497 230 - 1.638 1.648 0.035
ENSG00000167191 E007 17.1523256 0.0044010376 3.412588e-01 4.851816e-01 16 19858498 19858545 48 - 1.298 1.226 -0.252
ENSG00000167191 E008 20.2700973 0.0027493315 1.254638e-01 2.278118e-01 16 19858546 19858704 159 - 1.379 1.268 -0.387
ENSG00000167191 E009 30.9591003 0.0006727694 3.538180e-02 8.238662e-02 16 19858705 19858970 266 - 1.562 1.441 -0.415
ENSG00000167191 E010 407.9907432 0.0012552850 1.444645e-05 9.247318e-05 16 19858971 19860407 1437 - 2.562 2.651 0.296
ENSG00000167191 E011 72.9896131 0.0004218789 3.213765e-01 4.646095e-01 16 19860408 19860544 137 - 1.885 1.854 -0.104
ENSG00000167191 E012 67.5758867 0.0004653285 5.140056e-01 6.487679e-01 16 19861837 19861973 137 - 1.811 1.848 0.123
ENSG00000167191 E013 1.2417286 0.0690386912 5.598141e-02 1.196672e-01 16 19861974 19862340 367 - 0.119 0.481 2.693
ENSG00000167191 E014 123.3316512 0.0003056244 5.110117e-01 6.461323e-01 16 19871816 19872312 497 - 2.075 2.104 0.098
ENSG00000167191 E015 35.4294750 0.0006160132 3.927035e-01 5.366164e-01 16 19872313 19872400 88 - 1.577 1.536 -0.139
ENSG00000167191 E016 53.2507561 0.0005375981 7.814409e-02 1.564856e-01 16 19872401 19872575 175 - 1.767 1.692 -0.254
ENSG00000167191 E017 24.1692132 0.0008117567 2.121856e-01 3.411055e-01 16 19872576 19872586 11 - 1.438 1.360 -0.268
ENSG00000167191 E018 65.5563758 0.0003971554 4.506251e-02 1.003097e-01 16 19872587 19872768 182 - 1.859 1.783 -0.257
ENSG00000167191 E019 39.0032240 0.0005484048 8.202498e-03 2.429738e-02 16 19872769 19872846 78 - 1.665 1.528 -0.468
ENSG00000167191 E020 0.0000000       16 19874732 19874798 67 -      
ENSG00000167191 E021 0.1817044 0.0391112212 4.638856e-01   16 19880970 19880993 24 - 0.000 0.126 8.803
ENSG00000167191 E022 1.3284874 0.0458718205 3.668350e-01 5.111714e-01 16 19882132 19882301 170 - 0.460 0.302 -0.909
ENSG00000167191 E023 0.0000000       16 19882302 19882360 59 -      
ENSG00000167191 E024 26.8696967 0.0007521629 5.474360e-03 1.722002e-02 16 19884727 19884904 178 - 1.523 1.347 -0.607
ENSG00000167191 E025 0.0000000       16 19885203 19885925 723 -      
ENSG00000167191 E026 0.0000000       16 19885926 19886167 242 -