ENSG00000167173

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394987 ENSG00000167173 HEK293_OSMI2_2hA HEK293_TMG_2hB C15orf39 protein_coding protein_coding 34.98917 55.34141 27.8981 3.513934 0.6255028 -0.9879362 14.274665 22.138279 11.283746 0.8523426 1.0250595 -0.9716705 0.40876667 0.4015000 0.4059667 0.004466667 1.000000e+00 5.859364e-06 FALSE TRUE
ENST00000565074 ENSG00000167173 HEK293_OSMI2_2hA HEK293_TMG_2hB C15orf39 protein_coding protein_coding 34.98917 55.34141 27.8981 3.513934 0.6255028 -0.9879362 2.181336 2.238310 2.031698 0.3024783 0.2637533 -0.1390719 0.06748750 0.0401000 0.0725000 0.032400000 1.833057e-02 5.859364e-06 FALSE TRUE
ENST00000567617 ENSG00000167173 HEK293_OSMI2_2hA HEK293_TMG_2hB C15orf39 protein_coding protein_coding 34.98917 55.34141 27.8981 3.513934 0.6255028 -0.9879362 2.190740 8.583391 0.000000 3.8133626 0.0000000 -9.7470837 0.04665833 0.1635000 0.0000000 -0.163500000 5.859364e-06 5.859364e-06 FALSE TRUE
MSTRG.11231.6 ENSG00000167173 HEK293_OSMI2_2hA HEK293_TMG_2hB C15orf39 protein_coding   34.98917 55.34141 27.8981 3.513934 0.6255028 -0.9879362 15.590134 21.288901 13.586903 5.4206184 1.2193458 -0.6475009 0.45407500 0.3755667 0.4859667 0.110400000 5.691996e-01 5.859364e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167173 E001 0.000000       15 75195643 75195735 93 +      
ENSG00000167173 E002 0.000000       15 75198866 75198886 21 +      
ENSG00000167173 E003 0.000000       15 75198887 75198891 5 +      
ENSG00000167173 E004 1.486458 0.0736629766 1.785698e-01 2.993603e-01 15 75198892 75199161 270 + 0.523 0.281 -1.360
ENSG00000167173 E005 1.216825 0.0109394329 5.183474e-01 6.525913e-01 15 75201858 75201881 24 + 0.380 0.281 -0.623
ENSG00000167173 E006 128.773424 0.0089931348 4.937681e-03 1.575751e-02 15 75201882 75201960 79 + 2.145 2.029 -0.387
ENSG00000167173 E007 195.918242 0.0054365777 2.130704e-03 7.629242e-03 15 75201961 75202059 99 + 2.313 2.218 -0.319
ENSG00000167173 E008 7.207778 0.0109392937 2.300126e-01 3.624711e-01 15 75202205 75202426 222 + 0.951 0.826 -0.476
ENSG00000167173 E009 169.157985 0.0010445161 6.436873e-02 1.339845e-01 15 75205999 75206048 50 + 2.202 2.175 -0.088
ENSG00000167173 E010 627.208710 0.0029142677 1.468820e-08 1.755827e-07 15 75206049 75206443 395 + 2.834 2.715 -0.396
ENSG00000167173 E011 514.888821 0.0022793559 4.502921e-07 4.019720e-06 15 75206444 75206734 291 + 2.734 2.637 -0.325
ENSG00000167173 E012 365.601278 0.0008684116 7.572885e-03 2.270176e-02 15 75206735 75207102 368 + 2.538 2.509 -0.095
ENSG00000167173 E013 2364.621149 0.0004498085 9.532950e-01 9.747815e-01 15 75207103 75208824 1722 + 3.301 3.338 0.123
ENSG00000167173 E014 156.546119 0.0013919501 3.218452e-02 7.621100e-02 15 75208825 75208876 52 + 2.065 2.177 0.375
ENSG00000167173 E015 52.358754 0.0004785501 6.559112e-04 2.737315e-03 15 75208877 75209595 719 + 1.777 1.636 -0.477
ENSG00000167173 E016 1715.701199 0.0058203933 3.398474e-08 3.788799e-07 15 75210749 75212169 1421 + 3.037 3.240 0.675