ENSG00000167130

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327812 ENSG00000167130 HEK293_OSMI2_2hA HEK293_TMG_2hB DOLPP1 protein_coding nonsense_mediated_decay 47.74824 67.28919 32.45888 3.225977 0.8124929 -1.051532 1.303439 4.585304 0.000000 0.4376772 0.0000000 -8.844017 0.02135417 0.0690000 0.0000 -0.06900000 1.926587e-21 7.812373e-25 FALSE  
ENST00000372546 ENSG00000167130 HEK293_OSMI2_2hA HEK293_TMG_2hB DOLPP1 protein_coding protein_coding 47.74824 67.28919 32.45888 3.225977 0.8124929 -1.051532 42.856633 61.605011 28.183658 3.6037128 1.2319852 -1.127911 0.89264167 0.9146667 0.8675 -0.04716667 2.319870e-01 7.812373e-25 FALSE  
ENST00000406974 ENSG00000167130 HEK293_OSMI2_2hA HEK293_TMG_2hB DOLPP1 protein_coding protein_coding 47.74824 67.28919 32.45888 3.225977 0.8124929 -1.051532 2.453208 0.000000 3.035208 0.0000000 0.4522056 8.250397 0.06014167 0.0000000 0.0943 0.09430000 7.812373e-25 7.812373e-25 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167130 E001 3.862195 0.0135726916 3.349273e-01 4.786693e-01 9 129080932 129081110 179 + 0.743 0.630 -0.474
ENSG00000167130 E002 101.745635 0.0002773323 8.023712e-11 1.439186e-09 9 129081111 129081133 23 + 2.096 1.903 -0.647
ENSG00000167130 E003 150.843354 0.0002722702 2.209375e-07 2.100358e-06 9 129081134 129081139 6 + 2.216 2.101 -0.387
ENSG00000167130 E004 266.449312 0.0023589165 2.638663e-02 6.472284e-02 9 129081140 129081207 68 + 2.402 2.376 -0.086
ENSG00000167130 E005 4.060081 0.0967958109 6.047167e-01 7.251571e-01 9 129084599 129084667 69 + 0.706 0.639 -0.282
ENSG00000167130 E006 351.406873 0.0020245615 1.323770e-02 3.646763e-02 9 129084668 129084768 101 + 2.522 2.497 -0.084
ENSG00000167130 E007 306.123587 0.0006241424 2.974463e-04 1.369355e-03 9 129085023 129085107 85 + 2.474 2.431 -0.144
ENSG00000167130 E008 304.730786 0.0002130802 5.033126e-03 1.602243e-02 9 129085207 129085306 100 + 2.456 2.437 -0.066
ENSG00000167130 E009 335.909485 0.0001746661 3.545564e-03 1.185549e-02 9 129085518 129085616 99 + 2.499 2.480 -0.062
ENSG00000167130 E010 370.861843 0.0014018596 6.776700e-01 7.823254e-01 9 129086139 129086267 129 + 2.506 2.538 0.109
ENSG00000167130 E011 404.171306 0.0013929607 1.521323e-02 4.097153e-02 9 129086709 129086798 90 + 2.579 2.562 -0.056
ENSG00000167130 E012 2151.769281 0.0016951713 1.702766e-12 4.016310e-11 9 129088971 129090438 1468 + 3.192 3.332 0.464