ENSG00000167123

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372838 ENSG00000167123 HEK293_OSMI2_2hA HEK293_TMG_2hB CERCAM protein_coding protein_coding 39.53734 61.86113 26.4377 3.01555 1.819774 -1.226124 28.036761 49.871897 16.199100 2.5465163 0.87128968 -1.62171230 0.67704167 0.80600000 0.61460000 -0.1914 4.198017e-10 4.198017e-10 FALSE TRUE
ENST00000372842 ENSG00000167123 HEK293_OSMI2_2hA HEK293_TMG_2hB CERCAM protein_coding protein_coding 39.53734 61.86113 26.4377 3.01555 1.819774 -1.226124 2.643533 2.315576 2.467782 0.3762583 0.08415466 0.09146154 0.07705833 0.03703333 0.09383333 0.0568 4.598800e-06 4.198017e-10 FALSE TRUE
ENST00000483737 ENSG00000167123 HEK293_OSMI2_2hA HEK293_TMG_2hB CERCAM protein_coding retained_intron 39.53734 61.86113 26.4377 3.01555 1.819774 -1.226124 2.544479 1.596944 2.825897 0.3113246 0.72541763 0.81948571 0.07812917 0.02546667 0.10536667 0.0799 1.634157e-03 4.198017e-10   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167123 E001 0.0000000       9 128411751 128411765 15 +      
ENSG00000167123 E002 0.0000000       9 128411766 128412072 307 +      
ENSG00000167123 E003 0.4031496 0.0246830001 6.801652e-01 7.841251e-01 9 128419114 128419134 21 + 0.000 0.141 8.958
ENSG00000167123 E004 0.5546650 0.0217681645 7.627248e-01 8.462763e-01 9 128419135 128419147 13 + 0.191 0.141 -0.521
ENSG00000167123 E005 1.5876208 0.0106738739 8.042624e-01 8.754854e-01 9 128419148 128419159 12 + 0.323 0.370 0.284
ENSG00000167123 E006 5.3571333 0.0033726965 1.182728e-02 3.311769e-02 9 128419160 128419278 119 + 0.967 0.630 -1.343
ENSG00000167123 E007 2.8537386 0.1129776945 3.922469e-01 5.361859e-01 9 128419512 128419606 95 + 0.635 0.472 -0.757
ENSG00000167123 E008 2.7064896 0.2159483165 6.570998e-01 7.665321e-01 9 128419607 128419625 19 + 0.576 0.476 -0.478
ENSG00000167123 E009 0.4386386 0.1574779301 1.702907e-01 2.885527e-01 9 128419626 128419802 177 + 0.323 0.076 -2.534
ENSG00000167123 E010 1.1728179 0.0110497171 3.358483e-01 4.796745e-01 9 128420112 128420186 75 + 0.424 0.247 -1.108
ENSG00000167123 E011 6.9169060 0.1133934129 1.042161e-02 2.979993e-02 9 128420187 128420480 294 + 1.119 0.666 -1.742
ENSG00000167123 E012 9.4847515 0.1091699157 5.288815e-02 1.142892e-01 9 128420481 128420856 376 + 1.169 0.839 -1.219
ENSG00000167123 E013 157.9008706 0.0021103154 1.533739e-04 7.620405e-04 9 128420857 128421074 218 + 2.223 2.081 -0.473
ENSG00000167123 E014 20.7868182 0.0008907983 1.952244e-05 1.214088e-04 9 128421075 128421203 129 + 1.489 1.154 -1.169
ENSG00000167123 E015 41.4373985 0.0005474478 3.637008e-08 4.027945e-07 9 128421204 128421409 206 + 1.766 1.451 -1.074
ENSG00000167123 E016 37.3149788 0.0016410930 2.542687e-09 3.496693e-08 9 128421410 128421511 102 + 1.754 1.388 -1.249
ENSG00000167123 E017 153.0689419 0.0057638046 6.467227e-21 4.614677e-19 9 128421512 128422867 1356 + 2.396 1.966 -1.439
ENSG00000167123 E018 164.3314425 0.0002347469 8.256749e-05 4.401656e-04 9 128422868 128422914 47 + 2.229 2.107 -0.407
ENSG00000167123 E019 216.1225056 0.0001955523 5.394302e-03 1.699944e-02 9 128422915 128422978 64 + 2.312 2.236 -0.255
ENSG00000167123 E020 20.3461446 0.0143790092 7.918372e-10 1.196930e-08 9 128422979 128423145 167 + 1.616 1.042 -2.010
ENSG00000167123 E021 318.8634595 0.0002421771 2.054308e-03 7.394382e-03 9 128423146 128423263 118 + 2.477 2.406 -0.236
ENSG00000167123 E022 11.6642954 0.0227665863 4.005122e-04 1.776369e-03 9 128424036 128424137 102 + 1.319 0.905 -1.499
ENSG00000167123 E023 266.8514965 0.0002197105 2.984746e-02 7.166361e-02 9 128424138 128424205 68 + 2.388 2.333 -0.182
ENSG00000167123 E024 241.8071326 0.0001999756 3.073315e-01 4.495460e-01 9 128424206 128424272 67 + 2.324 2.296 -0.091
ENSG00000167123 E025 1.5801216 0.0108052947 1.082544e-01 2.029577e-01 9 128424273 128424273 1 + 0.575 0.292 -1.525
ENSG00000167123 E026 461.0076141 0.0001263867 1.577280e-01 2.720941e-01 9 128424410 128424601 192 + 2.602 2.575 -0.090
ENSG00000167123 E027 200.7218448 0.0002119427 3.791859e-01 5.234651e-01 9 128424602 128424614 13 + 2.240 2.214 -0.086
ENSG00000167123 E028 4.5101734 0.0160207057 4.886238e-02 1.071338e-01 9 128427652 128427779 128 + 0.882 0.589 -1.201
ENSG00000167123 E029 359.0187014 0.0002326310 1.691496e-01 2.870812e-01 9 128428302 128428421 120 + 2.448 2.478 0.103
ENSG00000167123 E030 1.9896139 0.0074601972 2.396147e-01 3.736586e-01 9 128428422 128428423 2 + 0.575 0.370 -1.039
ENSG00000167123 E031 278.3860814 0.0001537158 2.447153e-04 1.153191e-03 9 128428757 128428833 77 + 2.288 2.382 0.315
ENSG00000167123 E032 298.0988500 0.0001586442 4.547965e-06 3.268334e-05 9 128428930 128429036 107 + 2.301 2.417 0.384
ENSG00000167123 E033 7.2557089 0.0026131952 1.646422e-01 2.812151e-01 9 128430745 128430944 200 + 0.967 0.791 -0.675
ENSG00000167123 E034 301.5467405 0.0002721490 4.775001e-03 1.530388e-02 9 128431171 128431258 88 + 2.341 2.412 0.236
ENSG00000167123 E035 177.1237825 0.0008626078 3.061943e-01 4.483576e-01 9 128431259 128431264 6 + 2.139 2.174 0.117
ENSG00000167123 E036 239.1762049 0.0002644385 2.187220e-01 3.488770e-01 9 128431265 128431303 39 + 2.269 2.303 0.113
ENSG00000167123 E037 350.8216225 0.0001865447 2.810301e-05 1.682637e-04 9 128434102 128434229 128 + 2.385 2.482 0.324
ENSG00000167123 E038 404.7976950 0.0001403381 8.681276e-07 7.305622e-06 9 128434410 128434613 204 + 2.441 2.546 0.352
ENSG00000167123 E039 596.5523599 0.0008070573 2.069340e-06 1.604511e-05 9 128435653 128435905 253 + 2.613 2.716 0.343
ENSG00000167123 E040 735.5298239 0.0034691917 5.386302e-03 1.697727e-02 9 128436849 128437351 503 + 2.718 2.806 0.293