ENSG00000167118

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372853 ENSG00000167118 HEK293_OSMI2_2hA HEK293_TMG_2hB URM1 protein_coding protein_coding 54.19532 100.7443 28.1397 2.96647 0.8270218 -1.839651 39.907641 77.882769 19.438388 2.4102971 0.5868335 -2.001839 0.7110208 0.77296667 0.69080000 -0.082166667 3.100356e-06 3.100356e-06 FALSE  
ENST00000470840 ENSG00000167118 HEK293_OSMI2_2hA HEK293_TMG_2hB URM1 protein_coding nonsense_mediated_decay 54.19532 100.7443 28.1397 2.96647 0.8270218 -1.839651 4.696286 8.525779 2.422094 0.1890893 0.2220478 -1.811324 0.0885750 0.08483333 0.08616667 0.001333333 1.000000e+00 3.100356e-06 FALSE  
MSTRG.33451.1 ENSG00000167118 HEK293_OSMI2_2hA HEK293_TMG_2hB URM1 protein_coding   54.19532 100.7443 28.1397 2.96647 0.8270218 -1.839651 6.092178 10.523352 4.063602 0.5913810 0.1335883 -1.370588 0.1236500 0.10430000 0.14443333 0.040133333 4.637960e-03 3.100356e-06    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167118 E001 36.29726 0.0007422544 1.791263e-02 4.694732e-02 9 128371242 128371360 119 + 1.562 1.438 -0.425
ENSG00000167118 E002 125.23326 0.0002942861 9.058026e-06 6.080635e-05 9 128371361 128371370 10 + 2.097 1.969 -0.427
ENSG00000167118 E003 139.51483 0.0002836067 6.655111e-05 3.634385e-04 9 128371371 128371373 3 + 2.125 2.020 -0.350
ENSG00000167118 E004 154.58304 0.0003024361 1.194238e-04 6.112414e-04 9 128371374 128371374 1 + 2.161 2.067 -0.314
ENSG00000167118 E005 637.75669 0.0017722251 2.234260e-03 7.949401e-03 9 128371375 128371415 41 + 2.732 2.695 -0.124
ENSG00000167118 E006 2.43054 0.0809052949 8.874260e-01 9.320479e-01 9 128372442 128372571 130 + 0.448 0.447 -0.003
ENSG00000167118 E007 66.86042 0.0003772986 5.194977e-01 6.535880e-01 9 128377995 128378035 41 + 1.727 1.730 0.009
ENSG00000167118 E008 948.48746 0.0007553464 2.813281e-03 9.713322e-03 9 128378036 128378106 71 + 2.886 2.871 -0.048
ENSG00000167118 E009 1109.74844 0.0001621686 8.240762e-04 3.345450e-03 9 128387816 128387895 80 + 2.947 2.940 -0.022
ENSG00000167118 E010 663.07310 0.0001184832 9.805451e-01 9.918152e-01 9 128387896 128387897 2 + 2.687 2.725 0.124
ENSG00000167118 E011 100.46496 0.0013616945 8.621718e-12 1.814641e-10 9 128387898 128389260 1363 + 2.090 1.839 -0.844
ENSG00000167118 E012 982.30414 0.0004372001 4.798988e-01 6.182323e-01 9 128389261 128389309 49 + 2.848 2.898 0.168
ENSG00000167118 E013 61.16902 0.0020670849 8.515464e-04 3.443258e-03 9 128389310 128389665 356 + 1.807 1.660 -0.497
ENSG00000167118 E014 3903.43947 0.0021939094 1.179655e-06 9.650996e-06 9 128389666 128392016 2351 + 3.398 3.510 0.373