ENSG00000167113

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300452 ENSG00000167113 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ4 protein_coding protein_coding 73.55193 125.9929 48.91123 4.580883 0.6646763 -1.364924 23.710592 47.797423 13.862096 0.5960072 1.4429470 -1.78504881 0.30026250 0.38006667 0.28426667 -9.580000e-02 1.637097e-01 6.447847e-09 FALSE  
ENST00000372875 ENSG00000167113 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ4 protein_coding protein_coding 73.55193 125.9929 48.91123 4.580883 0.6646763 -1.364924 3.772332 2.364644 3.668600 0.4034740 0.3244132 0.63144562 0.06412917 0.01860000 0.07490000 5.630000e-02 6.447847e-09 6.447847e-09 FALSE  
ENST00000461102 ENSG00000167113 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ4 protein_coding processed_transcript 73.55193 125.9929 48.91123 4.580883 0.6646763 -1.364924 7.578641 8.945107 4.414683 0.6096056 0.1908694 -1.01713655 0.11172083 0.07106667 0.09036667 1.930000e-02 2.156740e-01 6.447847e-09    
ENST00000609948 ENSG00000167113 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ4 protein_coding protein_coding 73.55193 125.9929 48.91123 4.580883 0.6646763 -1.364924 20.034008 37.062898 10.783806 1.3447373 0.2870630 -1.78016131 0.26582083 0.29420000 0.22060000 -7.360000e-02 8.692579e-05 6.447847e-09    
MSTRG.33458.1 ENSG00000167113 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ4 protein_coding   73.55193 125.9929 48.91123 4.580883 0.6646763 -1.364924 4.769400 7.409218 7.151576 1.0280536 1.4201492 -0.05098997 0.06753333 0.05916667 0.14550000 8.633333e-02 3.019081e-02 6.447847e-09 FALSE  
MSTRG.33458.2 ENSG00000167113 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ4 protein_coding   73.55193 125.9929 48.91123 4.580883 0.6646763 -1.364924 3.849804 6.149507 2.385175 0.3460460 0.6261259 -1.36268351 0.05400000 0.04883333 0.04880000 -3.333333e-05 9.590898e-01 6.447847e-09 FALSE  
MSTRG.33458.3 ENSG00000167113 HEK293_OSMI2_2hA HEK293_TMG_2hB COQ4 protein_coding   73.55193 125.9929 48.91123 4.580883 0.6646763 -1.364924 3.722475 4.930842 3.357704 1.1804717 0.5669138 -0.55299170 0.05228333 0.03860000 0.06836667 2.976667e-02 2.423543e-01 6.447847e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167113 E001 2.060589 0.3217963595 5.368567e-01 6.685370e-01 9 128322448 128322489 42 + 0.563 0.403 -0.798
ENSG00000167113 E002 12.392533 0.0444521946 4.501660e-01 5.913122e-01 9 128322490 128322514 25 + 0.955 1.080 0.459
ENSG00000167113 E003 52.626571 0.0007318128 2.939258e-02 7.075614e-02 9 128322544 128322581 38 + 1.547 1.681 0.456
ENSG00000167113 E004 72.196570 0.0118807111 2.737980e-01 4.128939e-01 9 128322582 128322604 23 + 1.724 1.809 0.288
ENSG00000167113 E005 118.353734 0.0019825056 4.515279e-01 5.924767e-01 9 128322605 128322622 18 + 2.020 1.994 -0.088
ENSG00000167113 E006 392.579382 0.0001335103 5.570203e-01 6.855353e-01 9 128322623 128322771 149 + 2.507 2.524 0.056
ENSG00000167113 E007 297.357759 0.0001687651 7.689609e-01 8.507051e-01 9 128322772 128322838 67 + 2.391 2.403 0.039
ENSG00000167113 E008 214.389836 0.0072994424 8.053116e-01 8.761694e-01 9 128322839 128322851 13 + 2.245 2.263 0.061
ENSG00000167113 E009 355.632174 0.0054130570 1.355707e-01 2.419079e-01 9 128322852 128322928 77 + 2.425 2.493 0.228
ENSG00000167113 E010 479.239008 0.0035519426 3.223882e-01 4.656782e-01 9 128323016 128323147 132 + 2.576 2.617 0.135
ENSG00000167113 E011 192.982029 0.0001891415 3.600868e-06 2.648396e-05 9 128323148 128323282 135 + 2.095 2.245 0.499
ENSG00000167113 E012 267.935656 0.0007315953 5.105929e-11 9.474074e-10 9 128323283 128323586 304 + 2.198 2.397 0.665
ENSG00000167113 E013 322.099377 0.0002090641 1.638417e-02 4.357680e-02 9 128325143 128325239 97 + 2.472 2.422 -0.164
ENSG00000167113 E014 11.997229 0.0718321480 4.079746e-01 5.515601e-01 9 128325240 128325243 4 + 1.123 1.015 -0.395
ENSG00000167113 E015 10.234236 0.0682536443 9.447516e-02 1.820918e-01 9 128325244 128325281 38 + 1.157 0.908 -0.913
ENSG00000167113 E016 195.162204 0.0002228059 6.918201e-02 1.420124e-01 9 128325779 128325782 4 + 2.256 2.208 -0.158
ENSG00000167113 E017 401.932161 0.0001714838 2.604925e-04 1.218725e-03 9 128325783 128325881 99 + 2.583 2.515 -0.226
ENSG00000167113 E018 56.208238 0.0112083012 1.819407e-13 4.990318e-12 9 128325882 128326400 519 + 2.005 1.504 -1.696
ENSG00000167113 E019 306.273243 0.0043183725 9.585568e-04 3.816640e-03 9 128330412 128332152 1741 + 2.499 2.383 -0.384
ENSG00000167113 E020 521.740753 0.0005541010 1.233675e-02 3.434121e-02 9 128332153 128332282 130 + 2.679 2.635 -0.145
ENSG00000167113 E021 172.809440 0.0044260094 8.317733e-01 8.945764e-01 9 128332283 128332849 567 + 2.169 2.168 -0.004
ENSG00000167113 E022 449.833151 0.0004720738 5.333095e-02 1.150780e-01 9 128332850 128332943 94 + 2.608 2.573 -0.115
ENSG00000167113 E023 1034.826720 0.0025903809 1.105464e-02 3.129464e-02 9 128333474 128334072 599 + 2.889 2.959 0.231