ENSG00000167112

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372890 ENSG00000167112 HEK293_OSMI2_2hA HEK293_TMG_2hB TRUB2 protein_coding protein_coding 99.52569 143.865 78.51868 18.77004 1.485166 -0.8735242 5.750398 7.480264 5.111080 0.4002777 0.2340462 -0.5485685 0.06029583 0.05370000 0.06530000 0.011600000 0.5699218558 1.775961e-06 FALSE  
ENST00000460320 ENSG00000167112 HEK293_OSMI2_2hA HEK293_TMG_2hB TRUB2 protein_coding processed_transcript 99.52569 143.865 78.51868 18.77004 1.485166 -0.8735242 6.074961 11.666978 2.389599 0.6997891 0.3820532 -2.2828017 0.05875417 0.08286667 0.03053333 -0.052333333 0.0002619292 1.775961e-06 FALSE  
MSTRG.33456.1 ENSG00000167112 HEK293_OSMI2_2hA HEK293_TMG_2hB TRUB2 protein_coding   99.52569 143.865 78.51868 18.77004 1.485166 -0.8735242 15.923074 24.933924 10.606889 4.0253752 0.2207136 -1.2323273 0.15590833 0.17163333 0.13523333 -0.036400000 0.0364916512 1.775961e-06 TRUE  
MSTRG.33456.4 ENSG00000167112 HEK293_OSMI2_2hA HEK293_TMG_2hB TRUB2 protein_coding   99.52569 143.865 78.51868 18.77004 1.485166 -0.8735242 20.539023 28.236815 16.939258 3.5911905 1.5537675 -0.7368660 0.20612083 0.19823333 0.21536667 0.017133333 0.8189204124 1.775961e-06 FALSE  
MSTRG.33456.6 ENSG00000167112 HEK293_OSMI2_2hA HEK293_TMG_2hB TRUB2 protein_coding   99.52569 143.865 78.51868 18.77004 1.485166 -0.8735242 6.104124 9.056930 4.643610 2.2450818 0.5159622 -0.9622640 0.06187917 0.06300000 0.05913333 -0.003866667 0.9787588691 1.775961e-06 FALSE  
MSTRG.33456.9 ENSG00000167112 HEK293_OSMI2_2hA HEK293_TMG_2hB TRUB2 protein_coding   99.52569 143.865 78.51868 18.77004 1.485166 -0.8735242 43.269971 61.186775 36.314488 9.8341910 1.6136890 -0.7525131 0.43618750 0.42133333 0.46253333 0.041200000 0.5302275367 1.775961e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167112 E001 0.000000       9 128282405 128282932 528 -      
ENSG00000167112 E002 409.102452 0.0073311794 3.655088e-03 1.216973e-02 9 128305159 128308288 3130 - 2.661 2.513 -0.493
ENSG00000167112 E003 1292.639885 0.0003179228 5.279906e-02 1.141344e-01 9 128308289 128309692 1404 - 3.050 3.063 0.046
ENSG00000167112 E004 580.294166 0.0001532332 5.900224e-07 5.147737e-06 9 128309693 128309783 91 - 2.656 2.733 0.255
ENSG00000167112 E005 544.731134 0.0001618874 3.612316e-08 4.002939e-07 9 128309784 128309875 92 - 2.620 2.710 0.298
ENSG00000167112 E006 757.901339 0.0003789086 5.854017e-02 1.241299e-01 9 128310887 128311023 137 - 2.813 2.834 0.069
ENSG00000167112 E007 15.620199 0.0011353551 1.258012e-08 1.522854e-07 9 128311024 128311325 302 - 1.471 0.985 -1.725
ENSG00000167112 E008 5.392535 0.0031275523 1.584736e-02 4.239426e-02 9 128311326 128311362 37 - 0.979 0.661 -1.251
ENSG00000167112 E009 600.435560 0.0001214991 8.180654e-01 8.849883e-01 9 128311529 128311601 73 - 2.732 2.728 -0.012
ENSG00000167112 E010 1.984315 0.0072453766 8.007639e-01 8.730064e-01 9 128311602 128311687 86 - 0.478 0.429 -0.250
ENSG00000167112 E011 631.283498 0.0001303145 3.843375e-01 5.284972e-01 9 128313808 128313889 82 - 2.766 2.745 -0.070
ENSG00000167112 E012 545.078068 0.0015484499 1.237337e-01 2.252699e-01 9 128315567 128315628 62 - 2.719 2.672 -0.157
ENSG00000167112 E013 5.279831 0.0030950508 1.210547e-03 4.676353e-03 9 128315822 128315896 75 - 1.023 0.597 -1.690
ENSG00000167112 E014 557.853908 0.0001422887 1.418995e-01 2.506381e-01 9 128317152 128317226 75 - 2.721 2.689 -0.105
ENSG00000167112 E015 1.709981 0.0198196150 2.538922e-02 6.267884e-02 9 128317227 128317259 33 - 0.655 0.265 -2.060
ENSG00000167112 E016 645.261804 0.0009833314 2.477245e-01 3.832607e-01 9 128321599 128321730 132 - 2.783 2.748 -0.118
ENSG00000167112 E017 454.853494 0.0018731029 1.031926e-01 1.953372e-01 9 128322300 128322449 150 - 2.646 2.589 -0.188