ENSG00000167106

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373084 ENSG00000167106 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM102A protein_coding protein_coding 9.101015 12.84093 7.470478 1.056149 0.5434467 -0.7806702 3.637194 6.4387272 2.2730194 0.1446094 0.1872618 -1.4980713 0.38646667 0.509866667 0.30400000 -0.2058667 0.01250305 0.01250305 FALSE TRUE
ENST00000373095 ENSG00000167106 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM102A protein_coding protein_coding 9.101015 12.84093 7.470478 1.056149 0.5434467 -0.7806702 3.664716 4.9138037 3.5499461 0.7095085 0.2326640 -0.4679178 0.40702083 0.381800000 0.48416667 0.1023667 0.54062163 0.01250305 FALSE TRUE
ENST00000479828 ENSG00000167106 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM102A protein_coding processed_transcript 9.101015 12.84093 7.470478 1.056149 0.5434467 -0.7806702 0.911222 0.8815713 0.5881261 0.8815713 0.5881261 -0.5759004 0.09438750 0.060466667 0.06876667 0.0083000 0.98796464 0.01250305 FALSE FALSE
MSTRG.33434.1 ENSG00000167106 HEK293_OSMI2_2hA HEK293_TMG_2hB FAM102A protein_coding   9.101015 12.84093 7.470478 1.056149 0.5434467 -0.7806702 0.295805 0.1157234 0.5832991 0.0527200 0.2611691 2.2385059 0.03928333 0.009033333 0.08303333 0.0740000 0.09832159 0.01250305 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167106 E001 8.424584 0.0022029520 1.328129e-04 6.712645e-04 9 127940207 127940373 167 - 1.182 0.762 -1.570
ENSG00000167106 E002 3.956632 0.0040597396 2.108329e-04 1.010286e-03 9 127940374 127940410 37 - 0.953 0.427 -2.256
ENSG00000167106 E003 27.017581 0.0007419087 1.994406e-01 3.255434e-01 9 127940582 127940880 299 - 1.348 1.439 0.316
ENSG00000167106 E004 9.012286 0.0020680861 3.018123e-01 4.436382e-01 9 127940881 127940882 2 - 0.884 1.003 0.448
ENSG00000167106 E005 173.782496 0.0031631277 1.311546e-05 8.474367e-05 9 127940883 127941324 442 - 2.085 2.253 0.561
ENSG00000167106 E006 54.749610 0.0043026858 1.184685e-03 4.589018e-03 9 127941325 127941335 11 - 1.562 1.763 0.681
ENSG00000167106 E007 577.480978 0.0005667759 1.829655e-04 8.906487e-04 9 127941336 127943237 1902 - 2.685 2.742 0.190
ENSG00000167106 E008 9.449403 0.0023184559 9.398479e-01 9.662284e-01 9 127943238 127944614 1377 - 0.974 0.982 0.030
ENSG00000167106 E009 60.706469 0.0004128574 9.621640e-02 1.847005e-01 9 127944615 127944684 70 - 1.803 1.725 -0.264
ENSG00000167106 E010 76.073151 0.0004255618 5.991556e-01 7.206094e-01 9 127944777 127944898 122 - 1.862 1.840 -0.077
ENSG00000167106 E011 96.396529 0.0057074818 5.445077e-01 6.749733e-01 9 127945367 127945562 196 - 1.967 1.940 -0.093
ENSG00000167106 E012 81.854442 0.0040503339 6.768263e-01 7.816789e-01 9 127945649 127945753 105 - 1.893 1.873 -0.068
ENSG00000167106 E013 81.189181 0.0004203333 1.683725e-01 2.860675e-01 9 127948071 127948198 128 - 1.912 1.856 -0.190
ENSG00000167106 E014 46.374059 0.0007617635 4.538679e-01 5.945794e-01 9 127948199 127948225 27 - 1.665 1.624 -0.139
ENSG00000167106 E015 45.020975 0.0005613730 2.688629e-01 4.073356e-01 9 127948368 127948414 47 - 1.669 1.609 -0.205
ENSG00000167106 E016 64.242502 0.0003794468 3.334638e-03 1.124734e-02 9 127950423 127950539 117 - 1.862 1.731 -0.445
ENSG00000167106 E017 1.994924 0.0072438620 9.036269e-01 9.426782e-01 9 127950540 127950722 183 - 0.443 0.464 0.106
ENSG00000167106 E018 4.478712 0.0958931836 4.972931e-01 6.338392e-01 9 127953269 127953574 306 - 0.802 0.661 -0.575
ENSG00000167106 E019 43.401479 0.0005703478 9.424267e-03 2.734232e-02 9 127953575 127953604 30 - 1.697 1.555 -0.483
ENSG00000167106 E020 63.620297 0.0024761886 8.773344e-02 1.717011e-01 9 127953805 127953925 121 - 1.824 1.739 -0.287
ENSG00000167106 E021 0.000000       9 127963722 127963745 24 -      
ENSG00000167106 E022 0.000000       9 127972582 127972647 66 -      
ENSG00000167106 E023 112.144464 0.0121225692 2.168008e-03 7.744223e-03 9 127979992 127980989 998 - 2.128 1.953 -0.589