ENSG00000167088

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000579618 ENSG00000167088 HEK293_OSMI2_2hA HEK293_TMG_2hB SNRPD1 protein_coding protein_coding 302.2573 366.6671 336.5463 38.28885 6.108898 -0.123662 43.90215 63.70918 47.66871 7.580074 4.928164 -0.4183824 0.1459500 0.17333333 0.1414000 -0.03193333 3.382560e-01 1.83013e-11    
ENST00000582475 ENSG00000167088 HEK293_OSMI2_2hA HEK293_TMG_2hB SNRPD1 protein_coding protein_coding 302.2573 366.6671 336.5463 38.28885 6.108898 -0.123662 30.77790 25.24207 46.07631 4.920247 2.167749 0.8679367 0.0988375 0.06766667 0.1369333 0.06926667 2.671331e-06 1.83013e-11    
MSTRG.15546.1 ENSG00000167088 HEK293_OSMI2_2hA HEK293_TMG_2hB SNRPD1 protein_coding   302.2573 366.6671 336.5463 38.28885 6.108898 -0.123662 218.40919 268.22165 230.81183 24.824367 2.201971 -0.2166998 0.7254917 0.73316667 0.6860667 -0.04710000 6.743399e-02 1.83013e-11 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167088 E001 0.4448795 0.2763071956 2.305965e-01 3.631676e-01 18 21611610 21611678 69 + 0.001 0.261 9.473
ENSG00000167088 E002 5.7528063 0.0028885879 2.916219e-01 4.325014e-01 18 21612158 21612265 108 + 0.737 0.862 0.495
ENSG00000167088 E003 66.7265272 0.0003884441 3.350366e-02 7.878125e-02 18 21612266 21612313 48 + 1.887 1.780 -0.360
ENSG00000167088 E004 293.2485689 0.0004301175 1.616039e-18 8.675368e-17 18 21612314 21612330 17 + 2.580 2.364 -0.718
ENSG00000167088 E005 2413.8441986 0.0006201707 2.123480e-01 3.413029e-01 18 21612331 21612443 113 + 3.378 3.371 -0.025
ENSG00000167088 E006 3069.6881054 0.0004216502 7.336722e-03 2.209343e-02 18 21622725 21622801 77 + 3.475 3.480 0.017
ENSG00000167088 E007 3492.5126065 0.0002133700 5.563960e-05 3.098582e-04 18 21623748 21623870 123 + 3.528 3.540 0.039
ENSG00000167088 E008 1336.6309161 0.0001365661 3.710451e-04 1.662332e-03 18 21623871 21623874 4 + 3.107 3.130 0.075
ENSG00000167088 E009 2444.1621275 0.0001149969 5.713990e-13 1.456929e-11 18 21623875 21623939 65 + 3.356 3.399 0.140
ENSG00000167088 E010 2263.9569914 0.0001053456 8.281352e-07 7.000373e-06 18 21629062 21629189 128 + 3.334 3.359 0.082
ENSG00000167088 E011 1234.7766582 0.0052850054 3.752459e-15 1.315493e-13 18 21629190 21630137 948 + 3.236 2.945 -0.969
ENSG00000167088 E012 131.4592168 0.0051883518 7.511083e-08 7.814554e-07 18 21630138 21630485 348 + 2.258 1.998 -0.870
ENSG00000167088 E013 3.5323672 0.0082739596 1.572983e-06 1.251404e-05 18 21630486 21630618 133 + 0.962 0.196 -3.840
ENSG00000167088 E014 25.7218027 0.0075030309 2.782844e-16 1.133523e-14 18 21630619 21631579 961 + 1.711 1.016 -2.427
ENSG00000167088 E015 80.1536526 0.0130691087 3.365670e-17 1.534206e-15 18 21631580 21633127 1548 + 2.169 1.564 -2.038
ENSG00000167088 E016 21.1713060 0.1181091845 3.541558e-01 4.984244e-01 18 21633128 21633524 397 + 1.399 1.304 -0.330
ENSG00000167088 E017 0.0000000       18 21636027 21636085 59 +