ENSG00000167077

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000401548 ENSG00000167077 HEK293_OSMI2_2hA HEK293_TMG_2hB MEI1 protein_coding protein_coding 0.1413497 0.214668 0.115838 0.04768273 0.02188566 -0.8362277 0.002259388 0.000000000 0.009939275 0.000000000 0.009939275 0.9956129 0.01603913 0.00000000 0.06786667 0.06786667 0.73273469 0.03578967 FALSE TRUE
ENST00000403492 ENSG00000167077 HEK293_OSMI2_2hA HEK293_TMG_2hB MEI1 protein_coding protein_coding 0.1413497 0.214668 0.115838 0.04768273 0.02188566 -0.8362277 0.006840039 0.000000000 0.032918707 0.000000000 0.032918707 2.1016066 0.04619565 0.00000000 0.25790000 0.25790000 0.70212066 0.03578967 FALSE TRUE
ENST00000423900 ENSG00000167077 HEK293_OSMI2_2hA HEK293_TMG_2hB MEI1 protein_coding protein_coding 0.1413497 0.214668 0.115838 0.04768273 0.02188566 -0.8362277 0.029468022 0.000000000 0.000000000 0.000000000 0.000000000 0.0000000 0.10146957 0.00000000 0.00000000 0.00000000   0.03578967   FALSE
ENST00000460702 ENSG00000167077 HEK293_OSMI2_2hA HEK293_TMG_2hB MEI1 protein_coding retained_intron 0.1413497 0.214668 0.115838 0.04768273 0.02188566 -0.8362277 0.014711738 0.000000000 0.000000000 0.000000000 0.000000000 0.0000000 0.12487826 0.00000000 0.00000000 0.00000000   0.03578967   FALSE
ENST00000476893 ENSG00000167077 HEK293_OSMI2_2hA HEK293_TMG_2hB MEI1 protein_coding processed_transcript 0.1413497 0.214668 0.115838 0.04768273 0.02188566 -0.8362277 0.020442503 0.129335104 0.000000000 0.037648523 0.000000000 -3.8004869 0.11370870 0.64006667 0.00000000 -0.64006667 0.03578967 0.03578967 FALSE TRUE
ENST00000484966 ENSG00000167077 HEK293_OSMI2_2hA HEK293_TMG_2hB MEI1 protein_coding processed_transcript 0.1413497 0.214668 0.115838 0.04768273 0.02188566 -0.8362277 0.013913256 0.021481529 0.038875418 0.021481529 0.038875418 0.6346034 0.06245217 0.07746667 0.26546667 0.18800000 0.84933600 0.03578967   FALSE
ENST00000487535 ENSG00000167077 HEK293_OSMI2_2hA HEK293_TMG_2hB MEI1 protein_coding processed_transcript 0.1413497 0.214668 0.115838 0.04768273 0.02188566 -0.8362277 0.021152435 0.048721926 0.000000000 0.048721926 0.000000000 -2.5538993 0.14146087 0.19833333 0.00000000 -0.19833333 0.85708450 0.03578967 FALSE TRUE
ENST00000540833 ENSG00000167077 HEK293_OSMI2_2hA HEK293_TMG_2hB MEI1 protein_coding protein_coding 0.1413497 0.214668 0.115838 0.04768273 0.02188566 -0.8362277 0.006873615 0.006267905 0.012163977 0.006267905 0.012163977 0.4461883 0.09050000 0.02550000 0.16563333 0.14013333 0.89698571 0.03578967 FALSE TRUE
ENST00000651135 ENSG00000167077 HEK293_OSMI2_2hA HEK293_TMG_2hB MEI1 protein_coding retained_intron 0.1413497 0.214668 0.115838 0.04768273 0.02188566 -0.8362277 0.010898883 0.008861559 0.021940578 0.004963170 0.011214600 0.7599415 0.24683478 0.05860000 0.24313333 0.18453333 0.68000877 0.03578967 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167077 E001 0.0000000       22 41699503 41699513 11 +      
ENSG00000167077 E002 0.0000000       22 41699514 41699712 199 +      
ENSG00000167077 E003 0.1451727 0.05049689 0.29975938   22 41703331 41703454 124 + 0.142 0.000 -12.492
ENSG00000167077 E004 0.1451727 0.05049689 0.29975938   22 41705504 41705554 51 + 0.142 0.000 -14.865
ENSG00000167077 E005 0.0000000       22 41714002 41714075 74 +      
ENSG00000167077 E006 0.0000000       22 41716041 41716146 106 +      
ENSG00000167077 E007 0.1515154 0.04958111 0.29963817   22 41718071 41718274 204 + 0.142 0.000 -14.866
ENSG00000167077 E008 0.3030308 0.43410567 0.16866372   22 41723943 41724073 131 + 0.250 0.000 -15.463
ENSG00000167077 E009 0.1515154 0.04958111 0.29963817   22 41729665 41729779 115 + 0.142 0.000 -14.866
ENSG00000167077 E010 0.0000000       22 41730521 41730637 117 +      
ENSG00000167077 E011 0.0000000       22 41731056 41732244 1189 +      
ENSG00000167077 E012 0.0000000       22 41732245 41732344 100 +      
ENSG00000167077 E013 0.0000000       22 41732469 41732603 135 +      
ENSG00000167077 E014 0.2214452 0.04148872 0.75162708   22 41743080 41743194 115 + 0.000 0.105 12.951
ENSG00000167077 E015 0.3729606 0.03083220 0.71334007 0.80985765 22 41744973 41745064 92 + 0.142 0.105 -0.494
ENSG00000167077 E016 0.5117906 0.03256423 0.31231777 0.45485598 22 41745885 41746026 142 + 0.249 0.105 -1.493
ENSG00000167077 E017 0.1451727 0.05049689 0.29975938   22 41748107 41748218 112 + 0.142 0.000 -14.865
ENSG00000167077 E018 0.0000000       22 41752460 41752503 44 +      
ENSG00000167077 E019 0.0000000       22 41752504 41752516 13 +      
ENSG00000167077 E020 0.0000000       22 41752517 41752590 74 +      
ENSG00000167077 E021 0.0000000       22 41752591 41752651 61 +      
ENSG00000167077 E022 0.0000000       22 41753583 41753948 366 +      
ENSG00000167077 E023 0.0000000       22 41753949 41754046 98 +      
ENSG00000167077 E024 0.0000000       22 41758365 41758478 114 +      
ENSG00000167077 E025 0.0000000       22 41758479 41758533 55 +      
ENSG00000167077 E026 0.0000000       22 41758534 41758547 14 +      
ENSG00000167077 E027 0.0000000       22 41759349 41759446 98 +      
ENSG00000167077 E028 0.0000000       22 41763174 41763231 58 +      
ENSG00000167077 E029 0.0000000       22 41763232 41763249 18 +      
ENSG00000167077 E030 0.1451727 0.05049689 0.29975938   22 41763250 41763321 72 + 0.142 0.000 -14.865
ENSG00000167077 E031 0.0000000       22 41767576 41767608 33 +      
ENSG00000167077 E032 0.1451727 0.05049689 0.29975938   22 41770686 41770706 21 + 0.142 0.000 -14.865
ENSG00000167077 E033 0.1451727 0.05049689 0.29975938   22 41770707 41770809 103 + 0.142 0.000 -14.865
ENSG00000167077 E034 0.1451727 0.05049689 0.29975938   22 41770810 41770961 152 + 0.142 0.000 -14.865
ENSG00000167077 E035 0.0000000       22 41774180 41774498 319 +      
ENSG00000167077 E036 0.0000000       22 41776047 41776048 2 +      
ENSG00000167077 E037 0.0000000       22 41776049 41776101 53 +      
ENSG00000167077 E038 0.0000000       22 41776102 41776110 9 +      
ENSG00000167077 E039 0.0000000       22 41776111 41776267 157 +      
ENSG00000167077 E040 0.0000000       22 41778708 41778812 105 +      
ENSG00000167077 E041 0.0000000       22 41778813 41778877 65 +      
ENSG00000167077 E042 0.0000000       22 41781284 41781350 67 +      
ENSG00000167077 E043 0.0000000       22 41781351 41781363 13 +      
ENSG00000167077 E044 0.0000000       22 41781364 41781394 31 +      
ENSG00000167077 E045 0.0000000       22 41781395 41781398 4 +      
ENSG00000167077 E046 0.0000000       22 41781399 41781445 47 +      
ENSG00000167077 E047 0.6633060 0.02344012 0.12713037 0.23014386 22 41781446 41781684 239 + 0.334 0.105 -2.079
ENSG00000167077 E048 0.1515154 0.04958111 0.29963817   22 41781685 41781734 50 + 0.142 0.000 -14.866
ENSG00000167077 E049 0.1515154 0.04958111 0.29963817   22 41781735 41781737 3 + 0.142 0.000 -14.866
ENSG00000167077 E050 0.7761102 0.02015502 0.58753223 0.71079491 22 41781738 41781824 87 + 0.142 0.261 1.092
ENSG00000167077 E051 0.4428904 0.03673992 0.36415250 0.50852578 22 41781825 41781845 21 + 0.000 0.191 13.782
ENSG00000167077 E052 0.0000000       22 41784339 41784360 22 +      
ENSG00000167077 E053 0.3299976 0.03057960 0.36341009   22 41784361 41784420 60 + 0.000 0.190 13.775
ENSG00000167077 E054 0.7331471 0.01731332 0.09729930 0.18636196 22 41784608 41784783 176 + 0.000 0.321 14.652
ENSG00000167077 E055 1.2114379 0.01275559 0.01622669 0.04322592 22 41793829 41793910 82 + 0.000 0.465 15.301
ENSG00000167077 E056 0.7415557 0.02684121 0.05216927 0.11302060 22 41793911 41794370 460 + 0.406 0.105 -2.499
ENSG00000167077 E057 1.7712892 0.09511034 0.90274202 0.94207594 22 41794371 41794477 107 + 0.406 0.462 0.294
ENSG00000167077 E058 0.3299976 0.03057960 0.36341009   22 41795411 41795421 11 + 0.000 0.190 13.775
ENSG00000167077 E059 0.9211812 0.01594474 0.05269756 0.11395528 22 41795422 41795452 31 + 0.000 0.375 14.932
ENSG00000167077 E060 1.3180011 0.01293271 0.01641314 0.04364159 22 41795453 41795542 90 + 0.000 0.466 15.303
ENSG00000167077 E061 1.2835458 0.01196188 0.15891502 0.27369067 22 41795735 41795773 39 + 0.142 0.423 2.090
ENSG00000167077 E062 1.2093496 0.01485115 0.60057784 0.72178382 22 41795774 41795847 74 + 0.249 0.375 0.826
ENSG00000167077 E063 0.3289534 0.03185047 0.71208949   22 41799254 41799305 52 + 0.142 0.105 -0.496
ENSG00000167077 E064 0.1472490 0.04952041 0.30017627   22 41799306 41799340 35 + 0.142 0.000 -14.865
ENSG00000167077 E065 0.1472490 0.04952041 0.30017627   22 41799341 41799414 74 + 0.142 0.000 -14.865
ENSG00000167077 E066 0.0000000       22 41799415 41799454 40 +      
ENSG00000167077 E067 0.0000000       22 41799455 41799455 1 +      
ENSG00000167077 E068 0.0000000       22 41799456 41799456 1 +