ENSG00000167037

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000400358 ENSG00000167037 HEK293_OSMI2_2hA HEK293_TMG_2hB SGSM1 protein_coding protein_coding 3.248031 7.794787 1.383066 0.5030481 0.199386 -2.486096 0.5005579 0.7191724 0.55698258 0.1030543 0.04567329 -0.3629556 0.2109333 0.09133333 0.40966667 0.3183333 1.104919e-09 1.104919e-09 FALSE TRUE
ENST00000470591 ENSG00000167037 HEK293_OSMI2_2hA HEK293_TMG_2hB SGSM1 protein_coding processed_transcript 3.248031 7.794787 1.383066 0.5030481 0.199386 -2.486096 0.3357320 1.3215945 0.07990632 0.2044068 0.07990632 -3.8885884 0.0705875 0.16810000 0.04483333 -0.1232667 2.370835e-01 1.104919e-09   FALSE
MSTRG.21821.3 ENSG00000167037 HEK293_OSMI2_2hA HEK293_TMG_2hB SGSM1 protein_coding   3.248031 7.794787 1.383066 0.5030481 0.199386 -2.486096 2.3806710 5.7216814 0.73735407 0.2542124 0.08086408 -2.9390946 0.6978583 0.73610000 0.53796667 -0.1981333 7.141980e-03 1.104919e-09 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000167037 E001 0.0000000       22 24806169 24806210 42 +      
ENSG00000167037 E002 0.0000000       22 24806211 24806220 10 +      
ENSG00000167037 E003 11.7422999 0.001623280 2.109837e-05 1.301326e-04 22 24806221 24806306 86 + 0.630 1.158 2.033
ENSG00000167037 E004 12.4420358 0.001590334 6.130487e-06 4.278422e-05 22 24806307 24806318 12 + 0.630 1.184 2.127
ENSG00000167037 E005 16.1495782 0.001211808 3.370132e-06 2.495355e-05 22 24806319 24806344 26 + 0.788 1.282 1.820
ENSG00000167037 E006 17.6599720 0.001124661 1.688569e-03 6.246350e-03 22 24806441 24806484 44 + 0.995 1.287 1.050
ENSG00000167037 E007 3.6428955 0.004438672 1.671583e-02 4.431146e-02 22 24813678 24813755 78 + 0.287 0.706 2.128
ENSG00000167037 E008 17.5072460 0.001189930 3.155207e-07 2.906470e-06 22 24814009 24814192 184 + 0.788 1.321 1.957
ENSG00000167037 E009 0.0000000       22 24843460 24844740 1281 +      
ENSG00000167037 E010 0.0000000       22 24844741 24844896 156 +      
ENSG00000167037 E011 3.2031176 0.030993465 3.080880e-01 4.503332e-01 22 24844897 24844972 76 + 0.716 0.542 -0.760
ENSG00000167037 E012 4.7887507 0.003561286 1.820648e-01 3.038027e-01 22 24847634 24847796 163 + 0.850 0.665 -0.744
ENSG00000167037 E013 6.4441403 0.010326583 1.238585e-01 2.254630e-01 22 24850280 24850432 153 + 0.973 0.776 -0.757
ENSG00000167037 E014 5.4507178 0.004495490 1.752253e-01 2.949699e-01 22 24854996 24855063 68 + 0.630 0.824 0.792
ENSG00000167037 E015 9.2961899 0.016653188 8.642369e-01 9.164735e-01 22 24855285 24855430 146 + 0.994 0.972 -0.085
ENSG00000167037 E016 8.3513515 0.002553485 1.008109e-01 1.916963e-01 22 24855549 24855680 132 + 1.052 0.866 -0.695
ENSG00000167037 E017 7.2452412 0.002479187 3.566637e-01 5.010371e-01 22 24859716 24859840 125 + 0.951 0.839 -0.430
ENSG00000167037 E018 4.4344762 0.075622798 9.142807e-01 9.497236e-01 22 24867093 24867160 68 + 0.675 0.708 0.136
ENSG00000167037 E019 4.8847415 0.047841203 9.713304e-01 9.860949e-01 22 24868376 24868539 164 + 0.716 0.729 0.052
ENSG00000167037 E020 5.3955911 0.060623311 1.039001e-01 1.964525e-01 22 24868723 24868855 133 + 0.928 0.671 -1.018
ENSG00000167037 E021 0.3299976 0.028046933 4.751336e-01   22 24874415 24874579 165 + 0.000 0.162 8.789
ENSG00000167037 E022 5.3393371 0.025905102 1.930781e-01 3.176337e-01 22 24876577 24876715 139 + 0.877 0.689 -0.749
ENSG00000167037 E023 4.0483118 0.029973835 6.044425e-01 7.249934e-01 22 24879462 24879526 65 + 0.580 0.670 0.392
ENSG00000167037 E024 5.3769976 0.085121708 7.104033e-01 8.075905e-01 22 24884053 24884198 146 + 0.675 0.776 0.411
ENSG00000167037 E025 5.1564974 0.007171705 8.403050e-01 9.002875e-01 22 24886600 24886728 129 + 0.716 0.744 0.113
ENSG00000167037 E026 4.8888720 0.003519028 5.412634e-02 1.164706e-01 22 24893431 24893613 183 + 0.903 0.643 -1.043
ENSG00000167037 E027 2.6735570 0.009024801 7.012540e-01 8.004951e-01 22 24895223 24895291 69 + 0.580 0.514 -0.306
ENSG00000167037 E028 13.4267201 0.001516763 3.229296e-02 7.641810e-02 22 24897972 24898559 588 + 1.239 1.041 -0.712
ENSG00000167037 E029 6.4174340 0.033921615 8.068103e-02 1.606134e-01 22 24901833 24901957 125 + 0.974 0.731 -0.940
ENSG00000167037 E030 3.7622499 0.004521342 2.221871e-01 3.530157e-01 22 24905105 24905187 83 + 0.754 0.571 -0.779
ENSG00000167037 E031 4.6384815 0.003989379 1.024613e-01 1.942641e-01 22 24912643 24912752 110 + 0.850 0.621 -0.934
ENSG00000167037 E032 6.0526054 0.003187781 2.119452e-02 5.400454e-02 22 24917658 24917754 97 + 0.995 0.706 -1.121
ENSG00000167037 E033 8.2209181 0.008094015 3.292258e-03 1.112752e-02 22 24919826 24919993 168 + 1.134 0.794 -1.272
ENSG00000167037 E034 65.4312286 0.003049474 1.044450e-02 2.984972e-02 22 24924186 24927578 3393 + 1.852 1.738 -0.384