ENSG00000166938

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319194 ENSG00000166938 HEK293_OSMI2_2hA HEK293_TMG_2hB DIS3L protein_coding protein_coding 15.49281 8.934953 22.03821 0.7178215 0.08656209 1.301516 1.0163781 0.43146027 2.721364 0.22820404 0.6858762 2.629266 0.06000000 0.05293333 0.12323333 0.070300000 2.941832e-01 5.059675e-19 FALSE TRUE
ENST00000319212 ENSG00000166938 HEK293_OSMI2_2hA HEK293_TMG_2hB DIS3L protein_coding protein_coding 15.49281 8.934953 22.03821 0.7178215 0.08656209 1.301516 2.8401979 2.20442290 2.436884 0.76600608 0.6846532 0.144015 0.19977083 0.23793333 0.11073333 -0.127200000 4.125579e-01 5.059675e-19 FALSE TRUE
ENST00000530537 ENSG00000166938 HEK293_OSMI2_2hA HEK293_TMG_2hB DIS3L protein_coding nonsense_mediated_decay 15.49281 8.934953 22.03821 0.7178215 0.08656209 1.301516 0.8294103 1.56495055 0.000000 0.36786184 0.0000000 -7.299163 0.07000833 0.17136667 0.00000000 -0.171366667 5.059675e-19 5.059675e-19 FALSE TRUE
ENST00000532293 ENSG00000166938 HEK293_OSMI2_2hA HEK293_TMG_2hB DIS3L protein_coding processed_transcript 15.49281 8.934953 22.03821 0.7178215 0.08656209 1.301516 0.9259165 0.59015077 1.425073 0.32405089 0.2060655 1.257727 0.06270417 0.06150000 0.06466667 0.003166667 9.040584e-01 5.059675e-19 FALSE FALSE
ENST00000564909 ENSG00000166938 HEK293_OSMI2_2hA HEK293_TMG_2hB DIS3L protein_coding retained_intron 15.49281 8.934953 22.03821 0.7178215 0.08656209 1.301516 4.6057476 1.58689575 7.517179 0.01128324 0.6516503 2.236839 0.27489583 0.18013333 0.34086667 0.160733333 1.752800e-03 5.059675e-19 FALSE TRUE
ENST00000564945 ENSG00000166938 HEK293_OSMI2_2hA HEK293_TMG_2hB DIS3L protein_coding retained_intron 15.49281 8.934953 22.03821 0.7178215 0.08656209 1.301516 1.2328099 0.05223399 2.607939 0.05223399 0.3169562 5.394585 0.07202083 0.00580000 0.11830000 0.112500000 3.281588e-04 5.059675e-19 FALSE FALSE
ENST00000568874 ENSG00000166938 HEK293_OSMI2_2hA HEK293_TMG_2hB DIS3L protein_coding processed_transcript 15.49281 8.934953 22.03821 0.7178215 0.08656209 1.301516 0.8350823 0.10453488 1.143175 0.06994380 0.2012345 3.331752 0.05283750 0.01316667 0.05193333 0.038766667 1.055673e-01 5.059675e-19   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166938 E001 0.1472490 0.0437925972 7.762870e-01   15 66293217 66293236 20 + 0.096 0.000 -10.735
ENSG00000166938 E002 0.2944980 0.3744817140 4.797360e-01   15 66293237 66293259 23 + 0.175 0.000 -11.729
ENSG00000166938 E003 1.2617653 0.1186798716 5.128347e-01 6.477259e-01 15 66293260 66293290 31 + 0.396 0.269 -0.796
ENSG00000166938 E004 2.6063760 0.0256074236 2.180129e-02 5.525927e-02 15 66293291 66293306 16 + 0.674 0.268 -2.119
ENSG00000166938 E005 6.7257752 0.0024125405 8.788814e-05 4.651268e-04 15 66293307 66293336 30 + 1.028 0.497 -2.175
ENSG00000166938 E006 6.8211896 0.0086738075 6.576646e-04 2.743424e-03 15 66293337 66293367 31 + 1.018 0.553 -1.873
ENSG00000166938 E007 2.3939120 0.0061960620 7.130089e-01 8.095707e-01 15 66293501 66293567 67 + 0.541 0.497 -0.211
ENSG00000166938 E008 2.5390847 0.0057914543 5.801847e-01 7.049781e-01 15 66293568 66293571 4 + 0.571 0.497 -0.349
ENSG00000166938 E009 6.7536948 0.0023938235 2.940058e-01 4.350801e-01 15 66293572 66293587 16 + 0.926 0.817 -0.418
ENSG00000166938 E010 10.4720539 0.0016126199 4.399391e-01 5.816657e-01 15 66293588 66293595 8 + 1.075 1.017 -0.211
ENSG00000166938 E011 18.1458127 0.0175129791 3.745907e-01 5.190163e-01 15 66293596 66293638 43 + 1.303 1.237 -0.231
ENSG00000166938 E012 25.2213611 0.0131744261 2.631468e-01 4.010134e-01 15 66293639 66293735 97 + 1.439 1.361 -0.272
ENSG00000166938 E013 1.3932335 0.0098093923 7.744049e-01 8.545921e-01 15 66293832 66293842 11 + 0.395 0.358 -0.212
ENSG00000166938 E014 2.8293414 0.0216362542 9.461892e-01 9.702237e-01 15 66293843 66293916 74 + 0.571 0.601 0.135
ENSG00000166938 E015 5.4886066 0.0051186610 6.564960e-01 7.660400e-01 15 66293917 66293993 77 + 0.826 0.787 -0.151
ENSG00000166938 E016 5.6692537 0.0032021596 5.681682e-01 6.948586e-01 15 66293994 66294058 65 + 0.842 0.788 -0.212
ENSG00000166938 E017 8.1532830 0.0020880938 6.181192e-01 7.358399e-01 15 66294059 66294174 116 + 0.974 0.939 -0.130
ENSG00000166938 E018 7.5754317 0.0088291861 3.065271e-01 4.487160e-01 15 66294175 66294448 274 + 0.857 1.000 0.540
ENSG00000166938 E019 61.6032716 0.0031231773 1.660037e-03 6.153901e-03 15 66294988 66295096 109 + 1.841 1.694 -0.496
ENSG00000166938 E020 47.4448915 0.0008603065 6.941516e-02 1.423892e-01 15 66295097 66295141 45 + 1.706 1.633 -0.248
ENSG00000166938 E021 0.2214452 0.0442280155 3.007802e-01   15 66306762 66306819 58 + 0.000 0.155 12.037
ENSG00000166938 E022 0.2214452 0.0442280155 3.007802e-01   15 66306820 66306823 4 + 0.000 0.155 12.037
ENSG00000166938 E023 51.3797968 0.0117715676 1.725248e-01 2.914807e-01 15 66306824 66306896 73 + 1.745 1.673 -0.244
ENSG00000166938 E024 67.4462754 0.0004506853 2.642185e-02 6.478992e-02 15 66306897 66306952 56 + 1.861 1.787 -0.248
ENSG00000166938 E025 111.8812676 0.0002513222 5.839682e-02 1.238828e-01 15 66308709 66308844 136 + 2.064 2.024 -0.133
ENSG00000166938 E026 120.7735560 0.0002520794 1.864731e-01 3.093304e-01 15 66311724 66311900 177 + 2.089 2.071 -0.062
ENSG00000166938 E027 0.3686942 0.0315465530 7.173935e-01 8.127791e-01 15 66311901 66311901 1 + 0.096 0.155 0.792
ENSG00000166938 E028 94.7853875 0.0003812699 6.983033e-02 1.430952e-01 15 66314039 66314117 79 + 1.995 1.952 -0.144
ENSG00000166938 E029 141.9387256 0.0042642952 2.188178e-01 3.489925e-01 15 66315036 66315215 180 + 2.163 2.132 -0.102
ENSG00000166938 E030 137.3607909 0.0009061280 3.035625e-03 1.037076e-02 15 66318449 66318618 170 + 2.167 2.093 -0.246
ENSG00000166938 E031 77.4967979 0.0025235110 2.483153e-03 8.713849e-03 15 66320571 66320649 79 + 1.933 1.811 -0.410
ENSG00000166938 E032 84.0597559 0.0004580786 1.820277e-02 4.757152e-02 15 66320650 66320732 83 + 1.950 1.880 -0.236
ENSG00000166938 E033 153.2738297 0.0003647673 3.946401e-02 9.003622e-02 15 66322687 66322934 248 + 2.196 2.159 -0.123
ENSG00000166938 E034 100.3913902 0.0023279515 4.573277e-01 5.976613e-01 15 66323493 66323585 93 + 2.005 1.998 -0.022
ENSG00000166938 E035 242.8859702 0.0023703447 2.364363e-01 3.700363e-01 15 66325831 66326364 534 + 2.356 2.414 0.195
ENSG00000166938 E036 6.3043668 0.0034449494 4.992806e-02 1.090443e-01 15 66326365 66326561 197 + 0.737 0.999 1.010
ENSG00000166938 E037 54.6851960 0.0004581901 1.286916e-01 2.323322e-01 15 66328970 66328996 27 + 1.697 1.793 0.326
ENSG00000166938 E038 88.4481912 0.0006457603 6.072527e-02 1.278545e-01 15 66328997 66329124 128 + 1.903 1.999 0.323
ENSG00000166938 E039 65.7586129 0.0007139586 1.121912e-01 2.087458e-01 15 66329221 66329279 59 + 1.776 1.870 0.318
ENSG00000166938 E040 89.4697295 0.0008527438 1.348735e-01 2.409280e-01 15 66329280 66329399 120 + 1.914 1.995 0.275
ENSG00000166938 E041 6.6129710 0.0024009774 2.061018e-06 1.598582e-05 15 66329400 66329548 149 + 1.047 0.359 -2.984
ENSG00000166938 E042 9.9825562 0.0017639970 7.566324e-05 4.074176e-04 15 66329613 66330024 412 + 1.165 0.722 -1.671
ENSG00000166938 E043 93.6013268 0.0003439627 1.026762e-01 1.945831e-01 15 66331875 66332020 146 + 1.932 2.016 0.282
ENSG00000166938 E044 1.8885647 0.0081013508 7.408762e-01 8.301844e-01 15 66332021 66332735 715 + 0.474 0.433 -0.212
ENSG00000166938 E045 127.0849105 0.0029881657 1.278049e-02 3.539751e-02 15 66332736 66332910 175 + 2.049 2.173 0.415
ENSG00000166938 E046 0.7708142 0.0153787590 3.942061e-01 5.380829e-01 15 66332911 66333003 93 + 0.299 0.155 -1.211
ENSG00000166938 E047 302.9347461 0.0085500513 1.983501e-06 1.544338e-05 15 66333004 66335186 2183 + 2.362 2.603 0.803