ENSG00000166912

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435680 ENSG00000166912 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR10 protein_coding protein_coding 2.605914 1.32654 4.143594 0.03369874 0.2113897 1.635857 1.9155255 1.209705 2.8492977 0.04230076 0.11729098 1.229129 0.76690833 0.9119667 0.6883667 -0.2236 0.0002677759 0.0002677759 FALSE TRUE
ENST00000567567 ENSG00000166912 HEK293_OSMI2_2hA HEK293_TMG_2hB MTMR10 protein_coding nonsense_mediated_decay 2.605914 1.32654 4.143594 0.03369874 0.2113897 1.635857 0.1592126 0.000000 0.2168837 0.00000000 0.04333518 4.503881 0.04279583 0.0000000 0.0523000 0.0523 0.0278710304 0.0002677759 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166912 E001 0.1482932 0.0414547382 1.973554e-01   15 30929203 30929409 207 - 0.000 0.180 10.950
ENSG00000166912 E002 1.2866677 0.0459180402 1.139457e-02 3.210583e-02 15 30938941 30938947 7 - 0.149 0.610 2.905
ENSG00000166912 E003 41.2944808 0.0086300767 1.175352e-09 1.719037e-08 15 30938948 30939524 577 - 1.419 1.834 1.414
ENSG00000166912 E004 102.9922270 0.0002977009 6.102832e-04 2.570565e-03 15 30939525 30941206 1682 - 1.944 2.068 0.418
ENSG00000166912 E005 11.1288757 0.0017461490 3.054423e-01 4.475503e-01 15 30941207 30941208 2 - 1.010 1.127 0.422
ENSG00000166912 E006 15.7550560 0.0011975086 3.561591e-01 5.005510e-01 15 30941209 30941253 45 - 1.163 1.256 0.329
ENSG00000166912 E007 56.6024285 0.0005142007 2.636059e-01 4.015224e-01 15 30941254 30942072 819 - 1.745 1.703 -0.142
ENSG00000166912 E008 2.5412642 0.0061185651 9.010483e-02 1.752954e-01 15 30942073 30942889 817 - 0.611 0.308 -1.579
ENSG00000166912 E009 21.7601551 0.0089805297 2.803100e-01 4.201689e-01 15 30942890 30943072 183 - 1.353 1.269 -0.296
ENSG00000166912 E010 1.1792638 0.0119356369 2.699798e-01 4.085473e-01 15 30946210 30946403 194 - 0.387 0.181 -1.480
ENSG00000166912 E011 1.7305929 0.0092331206 6.079739e-01 7.278468e-01 15 30946404 30946771 368 - 0.387 0.486 0.521
ENSG00000166912 E012 0.2214452 0.0396115117 1.956232e-01   15 30946772 30946779 8 - 0.000 0.181 13.304
ENSG00000166912 E013 0.4804688 0.0211568447 8.692177e-01 9.199588e-01 15 30947054 30947129 76 - 0.149 0.181 0.329
ENSG00000166912 E014 19.5221784 0.0009995619 1.825545e-01 3.044161e-01 15 30947130 30947300 171 - 1.316 1.217 -0.350
ENSG00000166912 E015 22.7462427 0.0009586634 8.297482e-02 1.642031e-01 15 30948302 30948471 170 - 1.391 1.268 -0.431
ENSG00000166912 E016 2.3763979 0.0079141511 2.280069e-02 5.732763e-02 15 30948472 30950336 1865 - 0.611 0.181 -2.579
ENSG00000166912 E017 13.7074034 0.0017539811 2.347368e-03 8.299153e-03 15 30951968 30952038 71 - 1.226 0.915 -1.132
ENSG00000166912 E018 14.7788529 0.0045329014 3.133699e-03 1.065796e-02 15 30953562 30953631 70 - 1.246 0.942 -1.102
ENSG00000166912 E019 17.5760381 0.0036670566 4.723583e-02 1.042521e-01 15 30954763 30954893 131 - 1.285 1.110 -0.621
ENSG00000166912 E020 17.0477680 0.0080514835 8.018131e-01 8.737178e-01 15 30958863 30958951 89 - 1.231 1.218 -0.046
ENSG00000166912 E021 9.2176398 0.0018154444 7.415998e-01 8.307052e-01 15 30959034 30959045 12 - 0.993 0.966 -0.098
ENSG00000166912 E022 14.8579403 0.0013227617 1.958043e-01 3.209758e-01 15 30959046 30959121 76 - 1.204 1.092 -0.402
ENSG00000166912 E023 20.6213774 0.0103156579 1.123378e-01 2.089632e-01 15 30960881 30961073 193 - 1.345 1.205 -0.493
ENSG00000166912 E024 1.1093195 0.0114561364 3.633061e-01 5.077201e-01 15 30965875 30966040 166 - 0.349 0.181 -1.255
ENSG00000166912 E025 10.6756063 0.0018576159 8.408432e-01 9.006599e-01 15 30967920 30968010 91 - 1.044 1.033 -0.038
ENSG00000166912 E026 0.9684132 0.0142130014 4.885425e-01 6.260852e-01 15 30968011 30968211 201 - 0.307 0.181 -0.992
ENSG00000166912 E027 10.8481113 0.0015527941 8.041921e-01 8.754390e-01 15 30974314 30974392 79 - 1.036 1.073 0.136
ENSG00000166912 E028 11.8334790 0.0015526274 4.289080e-01 5.716409e-01 15 30974393 30974456 64 - 1.104 1.033 -0.257
ENSG00000166912 E029 12.4522062 0.0107534652 1.853862e-03 6.770155e-03 15 30974931 30975003 73 - 1.193 0.824 -1.365
ENSG00000166912 E030 15.4801161 0.0012031437 7.937721e-04 3.237341e-03 15 30976819 30976955 137 - 1.271 0.941 -1.191
ENSG00000166912 E031 16.8683555 0.0248079514 4.576305e-01 5.979472e-01 15 30990777 30990837 61 - 1.198 1.289 0.320
ENSG00000166912 E032 0.2214452 0.0396115117 1.956232e-01   15 30991258 30991446 189 - 0.000 0.181 13.304
ENSG00000166912 E033 15.4887604 0.0291860563 8.911566e-02 1.737814e-01 15 30991447 30991652 206 - 1.118 1.321 0.719