ENSG00000166908

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354947 ENSG00000166908 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4K2C protein_coding protein_coding 28.99304 41.82965 24.79193 2.984518 0.7220524 -0.7544183 25.424995 37.216447 20.13090 2.4312488 0.6594894 -0.8861999 0.87362500 0.89043333 0.8121333 -0.0783 4.558590e-03 1.697594e-09 FALSE  
MSTRG.7499.4 ENSG00000166908 HEK293_OSMI2_2hA HEK293_TMG_2hB PIP4K2C protein_coding   28.99304 41.82965 24.79193 2.984518 0.7220524 -0.7544183 1.268185 1.182419 2.91141 0.1485653 0.3702189 1.2927735 0.04798333 0.02816667 0.1169667 0.0888 1.697594e-09 1.697594e-09 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166908 E001 1.429663 0.0166152915 8.829473e-01 9.290908e-01 12 57591174 57591191 18 + 0.350 0.404 0.313
ENSG00000166908 E002 4.369704 0.0083934226 5.926418e-01 7.151451e-01 12 57591192 57591202 11 + 0.633 0.750 0.486
ENSG00000166908 E003 4.369704 0.0083934226 5.926418e-01 7.151451e-01 12 57591203 57591205 3 + 0.633 0.750 0.486
ENSG00000166908 E004 8.157768 0.0441648229 1.377490e-01 2.449432e-01 12 57591206 57591216 11 + 1.053 0.871 -0.680
ENSG00000166908 E005 16.134623 0.0018703110 2.382982e-02 5.946296e-02 12 57591217 57591221 5 + 1.300 1.149 -0.534
ENSG00000166908 E006 35.398170 0.0006153789 7.089560e-01 8.064801e-01 12 57591222 57591242 21 + 1.521 1.543 0.075
ENSG00000166908 E007 36.206458 0.0005851076 9.042781e-01 9.430659e-01 12 57591243 57591245 3 + 1.521 1.558 0.129
ENSG00000166908 E008 51.367571 0.0004853472 6.515034e-01 7.623649e-01 12 57591246 57591265 20 + 1.681 1.704 0.076
ENSG00000166908 E009 125.998421 0.0002792955 5.916436e-04 2.502793e-03 12 57591266 57591400 135 + 2.122 2.057 -0.220
ENSG00000166908 E010 99.983084 0.0006148550 9.744406e-03 2.813455e-02 12 57591401 57591434 34 + 2.012 1.961 -0.172
ENSG00000166908 E011 87.263107 0.0003326743 1.358826e-03 5.172616e-03 12 57591435 57591463 29 + 1.972 1.894 -0.264
ENSG00000166908 E012 139.386000 0.0033597076 4.631662e-03 1.490698e-02 12 57594025 57594099 75 + 2.169 2.098 -0.236
ENSG00000166908 E013 102.393432 0.0025296549 6.490664e-03 1.989897e-02 12 57594100 57594122 23 + 2.038 1.969 -0.230
ENSG00000166908 E014 111.921173 0.0014287456 5.766984e-03 1.800099e-02 12 57595126 57595156 31 + 2.069 2.011 -0.197
ENSG00000166908 E015 165.129536 0.0015147289 5.963507e-06 4.173816e-05 12 57595157 57595222 66 + 2.263 2.161 -0.342
ENSG00000166908 E016 251.997499 0.0017452114 5.560598e-08 5.930522e-07 12 57595888 57596031 144 + 2.453 2.342 -0.373
ENSG00000166908 E017 4.130873 0.0040863112 2.599965e-02 6.394583e-02 12 57597958 57598062 105 + 0.857 0.582 -1.132
ENSG00000166908 E018 151.704889 0.0002652364 5.840000e-07 5.101172e-06 12 57599065 57599089 25 + 2.228 2.127 -0.337
ENSG00000166908 E019 247.110772 0.0008342679 1.864929e-07 1.797168e-06 12 57599090 57599211 122 + 2.429 2.340 -0.297
ENSG00000166908 E020 125.608835 0.0002776536 9.659600e-04 3.841764e-03 12 57599400 57599438 39 + 2.118 2.057 -0.206
ENSG00000166908 E021 238.646155 0.0002224087 7.528442e-02 1.519832e-01 12 57600324 57600437 114 + 2.354 2.357 0.011
ENSG00000166908 E022 335.776863 0.0025029625 9.680311e-01 9.840081e-01 12 57600811 57601078 268 + 2.472 2.519 0.158
ENSG00000166908 E023 210.274476 0.0002389006 3.011980e-01 4.429829e-01 12 57601245 57601348 104 + 2.251 2.324 0.244
ENSG00000166908 E024 231.823220 0.0022525273 7.017465e-01 8.007793e-01 12 57601526 57601636 111 + 2.303 2.361 0.192
ENSG00000166908 E025 416.805568 0.0006519423 8.965597e-01 9.378619e-01 12 57601637 57601925 289 + 2.565 2.614 0.161
ENSG00000166908 E026 1572.940483 0.0024020268 1.012793e-16 4.354756e-15 12 57601926 57603418 1493 + 3.031 3.232 0.670