ENSG00000166888

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300134 ENSG00000166888 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT6 protein_coding protein_coding 9.183423 15.39286 5.794911 0.4965876 0.279703 -1.407852 4.6850117 9.9659939 2.2454414 0.21978044 0.47048102 -2.1450507 0.46999167 0.64856667 0.38210000 -0.26646667 0.007523238 0.007523238 FALSE TRUE
ENST00000554764 ENSG00000166888 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT6 protein_coding nonsense_mediated_decay 9.183423 15.39286 5.794911 0.4965876 0.279703 -1.407852 1.6611150 2.3643723 1.2457833 0.41195841 0.53414111 -0.9189586 0.19437917 0.15216667 0.22446667 0.07230000 0.935253618 0.007523238 FALSE TRUE
ENST00000555222 ENSG00000166888 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT6 protein_coding retained_intron 9.183423 15.39286 5.794911 0.4965876 0.279703 -1.407852 0.9523171 1.3044687 0.6937597 0.23749337 0.16362540 -0.9013250 0.10402917 0.08586667 0.11776667 0.03190000 0.663422851 0.007523238 TRUE TRUE
ENST00000555641 ENSG00000166888 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT6 protein_coding retained_intron 9.183423 15.39286 5.794911 0.4965876 0.279703 -1.407852 0.4634639 0.3496011 0.3168749 0.08173337 0.05282825 -0.1376589 0.05601667 0.02263333 0.05490000 0.03226667 0.084330171 0.007523238 TRUE TRUE
ENST00000557781 ENSG00000166888 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT6 protein_coding retained_intron 9.183423 15.39286 5.794911 0.4965876 0.279703 -1.407852 0.4178182 0.3132951 0.3439718 0.04923184 0.07490630 0.1307825 0.05396250 0.02056667 0.05843333 0.03786667 0.026580611 0.007523238 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166888 E001 1.0297335 0.0121989077 1.568186e-01 2.708607e-01 12 57095408 57095432 25 - 0.000 0.316 10.201
ENSG00000166888 E002 5.0809028 0.0045552737 6.785212e-02 1.398051e-01 12 57095433 57095477 45 - 0.444 0.764 1.430
ENSG00000166888 E003 114.2691779 0.0010791426 4.031183e-09 5.343518e-08 12 57095478 57095851 374 - 1.727 2.009 0.949
ENSG00000166888 E004 78.6717790 0.0014731982 2.784097e-05 1.668424e-04 12 57095852 57095903 52 - 1.604 1.841 0.800
ENSG00000166888 E005 173.3005671 0.0026492830 6.452204e-06 4.479116e-05 12 57095904 57096199 296 - 1.983 2.177 0.653
ENSG00000166888 E006 66.0420594 0.0131453578 4.819336e-01 6.201123e-01 12 57096200 57096242 43 - 1.681 1.743 0.212
ENSG00000166888 E007 41.5668193 0.0057615075 6.890380e-01 7.910181e-01 12 57096243 57096247 5 - 1.512 1.545 0.112
ENSG00000166888 E008 98.7801572 0.0003038590 2.793799e-02 6.789081e-02 12 57096248 57096340 93 - 1.818 1.917 0.334
ENSG00000166888 E009 57.5903757 0.0037651204 1.435522e-02 3.903590e-02 12 57096341 57096344 4 - 1.527 1.692 0.562
ENSG00000166888 E010 61.4629505 0.0011668735 1.419753e-02 3.867260e-02 12 57096345 57096364 20 - 1.571 1.718 0.500
ENSG00000166888 E011 185.5354776 0.0002566528 4.082647e-04 1.806102e-03 12 57096365 57096722 358 - 2.074 2.191 0.392
ENSG00000166888 E012 54.8588459 0.0004297891 2.140385e-01 3.433064e-01 12 57096723 57096761 39 - 1.591 1.665 0.251
ENSG00000166888 E013 94.4675946 0.0004043263 1.717444e-01 2.904782e-01 12 57096850 57096978 129 - 1.833 1.896 0.210
ENSG00000166888 E014 64.6024747 0.0005851239 4.268547e-02 9.597012e-02 12 57097068 57097104 37 - 1.629 1.743 0.385
ENSG00000166888 E015 55.1116013 0.0004965888 3.055598e-01 4.476775e-01 12 57097105 57097133 29 - 1.604 1.665 0.207
ENSG00000166888 E016 0.1451727 0.0433742520 1.361062e-01   12 57097134 57097290 157 - 0.203 0.000 -13.206
ENSG00000166888 E017 63.5128059 0.0016917298 5.196971e-01 6.537650e-01 12 57098505 57098550 46 - 1.681 1.719 0.129
ENSG00000166888 E018 64.9207034 0.0017231579 8.101491e-01 8.795116e-01 12 57098551 57098590 40 - 1.731 1.720 -0.039
ENSG00000166888 E019 44.4285504 0.0010881150 1.430499e-01 2.521786e-01 12 57098591 57098597 7 - 1.629 1.540 -0.304
ENSG00000166888 E020 0.5901540 0.0229225288 2.994700e-02 7.185391e-02 12 57098745 57098791 47 - 0.444 0.071 -3.324
ENSG00000166888 E021 88.3400979 0.0019808105 2.114385e-01 3.401874e-01 12 57098792 57098902 111 - 1.900 1.842 -0.194
ENSG00000166888 E022 4.5423515 0.0177251913 6.971411e-02 1.428925e-01 12 57098903 57099014 112 - 0.877 0.604 -1.116
ENSG00000166888 E023 74.5416061 0.0053537296 4.740763e-01 6.129364e-01 12 57099015 57099078 64 - 1.745 1.791 0.155
ENSG00000166888 E024 10.6734290 0.0027505116 2.249293e-02 5.670737e-02 12 57099079 57099293 215 - 1.166 0.919 -0.904
ENSG00000166888 E025 108.8975775 0.0009872879 7.695767e-01 8.511878e-01 12 57099294 57099418 125 - 1.931 1.945 0.047
ENSG00000166888 E026 58.8088349 0.0004706261 5.656038e-01 6.926614e-01 12 57099419 57099440 22 - 1.707 1.677 -0.102
ENSG00000166888 E027 107.3882405 0.0003715132 4.295560e-02 9.646411e-02 12 57099767 57099903 137 - 2.001 1.922 -0.267
ENSG00000166888 E028 74.2219325 0.0065574339 1.140024e-01 2.113561e-01 12 57099996 57100090 95 - 1.852 1.756 -0.324
ENSG00000166888 E029 1.8016816 0.0116281683 4.924366e-03 1.571926e-02 12 57100846 57100899 54 - 0.713 0.234 -2.543
ENSG00000166888 E030 96.1701897 0.0003091734 1.142076e-01 2.116743e-01 12 57102290 57102496 207 - 1.940 1.875 -0.220
ENSG00000166888 E031 70.4534185 0.0004572906 3.660694e-03 1.218433e-02 12 57102829 57102921 93 - 1.859 1.721 -0.468
ENSG00000166888 E032 1.2051969 0.0667592243 7.538784e-01 8.396558e-01 12 57102922 57102990 69 - 0.340 0.277 -0.410
ENSG00000166888 E033 11.8276015 0.0146085088 5.167864e-04 2.222456e-03 12 57103273 57104463 1191 - 1.302 0.917 -1.390
ENSG00000166888 E034 40.0573142 0.0064336159 2.852535e-02 6.906653e-02 12 57104464 57104467 4 - 1.636 1.477 -0.541
ENSG00000166888 E035 72.7201869 0.0003989450 1.169605e-02 3.281033e-02 12 57104468 57104586 119 - 1.859 1.741 -0.401
ENSG00000166888 E036 63.0982819 0.0004417620 6.698353e-02 1.383570e-01 12 57104726 57104813 88 - 1.781 1.688 -0.315
ENSG00000166888 E037 79.5667608 0.0003269833 2.973821e-01 4.387143e-01 12 57105151 57105339 189 - 1.845 1.797 -0.161
ENSG00000166888 E038 61.0876575 0.0004487018 6.485466e-01 7.600270e-01 12 57105468 57105599 132 - 1.712 1.688 -0.080
ENSG00000166888 E039 9.6390765 0.0073521214 7.464818e-03 2.242396e-02 12 57105600 57106190 591 - 1.166 0.860 -1.132
ENSG00000166888 E040 53.6338484 0.0042810002 5.278524e-01 6.608210e-01 12 57106191 57106339 149 - 1.670 1.630 -0.135
ENSG00000166888 E041 33.5215970 0.0006460466 3.782387e-01 5.225153e-01 12 57106528 57106580 53 - 1.487 1.426 -0.211
ENSG00000166888 E042 22.6189032 0.0019190964 1.814611e-01 3.030810e-01 12 57106693 57106707 15 - 1.361 1.250 -0.391
ENSG00000166888 E043 25.9758204 0.0008459434 6.134862e-01 7.321556e-01 12 57106708 57106736 29 - 1.361 1.322 -0.139
ENSG00000166888 E044 24.3945449 0.0008618631 2.084527e-01 3.366156e-01 12 57106737 57106749 13 - 1.383 1.283 -0.350
ENSG00000166888 E045 48.3385520 0.0010530309 3.469945e-02 8.107081e-02 12 57106750 57106831 82 - 1.691 1.568 -0.418
ENSG00000166888 E046 34.4834837 0.0006170454 2.273212e-02 5.719774e-02 12 57107231 57107255 25 - 1.571 1.420 -0.518
ENSG00000166888 E047 46.2733208 0.0005106553 1.940957e-02 5.022173e-02 12 57107256 57107314 59 - 1.681 1.545 -0.463
ENSG00000166888 E048 27.5395869 0.0007176481 4.496104e-02 1.001250e-01 12 57107605 57107636 32 - 1.470 1.322 -0.514
ENSG00000166888 E049 24.0176060 0.0103523342 2.891265e-01 4.298060e-01 12 57107637 57107658 22 - 1.372 1.275 -0.341
ENSG00000166888 E050 20.5461965 0.0021781938 1.615192e-01 2.770851e-01 12 57107659 57107665 7 - 1.326 1.204 -0.430
ENSG00000166888 E051 35.5466661 0.0096227636 5.732888e-02 1.220340e-01 12 57107666 57107743 78 - 1.578 1.427 -0.519
ENSG00000166888 E052 55.1501186 0.0134080427 1.749000e-01 2.945479e-01 12 57108163 57108299 137 - 1.727 1.626 -0.340
ENSG00000166888 E053 1.5844872 0.0099524505 4.879912e-01 6.256156e-01 12 57109941 57110042 102 - 0.444 0.316 -0.736
ENSG00000166888 E054 2.1766288 0.0068331944 5.260335e-01 6.593195e-01 12 57110043 57110076 34 - 0.529 0.416 -0.568
ENSG00000166888 E055 3.1666956 0.0050698965 9.337977e-01 9.622694e-01 12 57110077 57110110 34 - 0.529 0.544 0.071
ENSG00000166888 E056 0.2214452 0.0388656442 1.000000e+00   12 57110111 57110340 230 - 0.000 0.071 10.136
ENSG00000166888 E057 0.1472490 0.0428406267 1.362419e-01   12 57110382 57110543 162 - 0.203 0.000 -13.212
ENSG00000166888 E058 0.6664265 0.0172671820 2.446471e-01 3.796375e-01 12 57111110 57111128 19 - 0.340 0.132 -1.737
ENSG00000166888 E059 42.3871606 0.0063989138 6.242862e-01 7.406496e-01 12 57111129 57111433 305 - 1.564 1.529 -0.119
ENSG00000166888 E060 0.0000000       12 57128973 57129100 128 -      
ENSG00000166888 E061 0.0000000       12 57132021 57132139 119 -