ENSG00000166886

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300131 ENSG00000166886 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB2 protein_coding protein_coding 7.404876 11.95531 5.941698 0.594479 0.1078812 -1.007484 4.4818822 7.0430853 3.5195733 0.9156233 0.07674419 -0.9987607 0.61894167 0.58440000 0.5930667 0.008666667 9.851542e-01 1.101791e-07 FALSE  
ENST00000342556 ENSG00000166886 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB2 protein_coding protein_coding 7.404876 11.95531 5.941698 0.594479 0.1078812 -1.007484 2.3458144 3.9994285 1.7231054 0.3463809 0.11417900 -1.2100372 0.30580417 0.33573333 0.2895333 -0.046200000 6.609997e-01 1.101791e-07 FALSE  
ENST00000554839 ENSG00000166886 HEK293_OSMI2_2hA HEK293_TMG_2hB NAB2 protein_coding retained_intron 7.404876 11.95531 5.941698 0.594479 0.1078812 -1.007484 0.3777449 0.2491422 0.6632819 0.0358926 0.05503498 1.3774669 0.05764583 0.02063333 0.1114667 0.090833333 1.101791e-07 1.101791e-07    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166886 E001 1.216838 0.1369248065 0.5062269658 0.641886921 12 57089043 57089093 51 + 0.399 0.269 -0.815
ENSG00000166886 E002 1.849854 0.0081333665 0.2708537365 0.409506778 12 57089094 57089113 20 + 0.545 0.356 -0.983
ENSG00000166886 E003 7.036920 0.0739772634 0.4873777874 0.625044914 12 57089114 57089146 33 + 0.931 0.816 -0.443
ENSG00000166886 E004 35.652048 0.0006282458 0.9215400481 0.954469646 12 57089147 57089354 208 + 1.499 1.509 0.032
ENSG00000166886 E005 33.883582 0.0006024098 0.1678093218 0.285343475 12 57091125 57091230 106 + 1.545 1.461 -0.289
ENSG00000166886 E006 21.979930 0.0008869040 0.4101720592 0.553773094 12 57091231 57091233 3 + 1.353 1.292 -0.214
ENSG00000166886 E007 139.636674 0.0017543479 0.4545008159 0.595140358 12 57091234 57091756 523 + 2.064 2.094 0.103
ENSG00000166886 E008 109.039026 0.0009751289 0.0879716184 0.172033457 12 57091757 57091998 242 + 1.925 1.995 0.234
ENSG00000166886 E009 3.949242 0.0040815132 0.0009776915 0.003883441 12 57092149 57092447 299 + 0.930 0.463 -1.982
ENSG00000166886 E010 100.277742 0.0003289860 0.1912588441 0.315315596 12 57092448 57092581 134 + 1.976 1.931 -0.152
ENSG00000166886 E011 73.782033 0.0004778977 0.1610765247 0.276525916 12 57092917 57092968 52 + 1.855 1.797 -0.195
ENSG00000166886 E012 102.207343 0.0003539396 0.3603847451 0.504700086 12 57093063 57093195 133 + 1.976 1.946 -0.103
ENSG00000166886 E013 60.549980 0.0003965850 0.8815194160 0.928088700 12 57093407 57093598 192 + 1.733 1.729 -0.014
ENSG00000166886 E014 231.548667 0.0015009623 0.0455369368 0.101183876 12 57094612 57095476 865 + 2.265 2.323 0.196