ENSG00000166881

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300128 ENSG00000166881 HEK293_OSMI2_2hA HEK293_TMG_2hB NEMP1 protein_coding protein_coding 22.46041 8.0188 30.10837 1.871325 0.6405588 1.907388 17.5684986 4.504473 23.256715 0.3522292 1.80208797 2.3656379 0.75924583 0.6302000 0.77163333 0.14143333 0.68787232 0.0004339695 FALSE TRUE
ENST00000379391 ENSG00000166881 HEK293_OSMI2_2hA HEK293_TMG_2hB NEMP1 protein_coding protein_coding 22.46041 8.0188 30.10837 1.871325 0.6405588 1.907388 1.3872648 2.029223 1.638711 1.2007922 0.31816260 -0.3066812 0.09666667 0.2158667 0.05453333 -0.16133333 0.03967824 0.0004339695 FALSE TRUE
MSTRG.7483.3 ENSG00000166881 HEK293_OSMI2_2hA HEK293_TMG_2hB NEMP1 protein_coding   22.46041 8.0188 30.10837 1.871325 0.6405588 1.907388 1.6111503 1.285011 1.561806 0.9413244 0.03245867 0.2794585 0.07665417 0.1282000 0.05193333 -0.07626667 0.59151365 0.0004339695 FALSE TRUE
MSTRG.7483.4 ENSG00000166881 HEK293_OSMI2_2hA HEK293_TMG_2hB NEMP1 protein_coding   22.46041 8.0188 30.10837 1.871325 0.6405588 1.907388 0.7652459 0.000000 1.690652 0.0000000 1.17588228 7.4099443 0.02238750 0.0000000 0.05693333 0.05693333 0.38974955 0.0004339695 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166881 E001 46.529491 0.0090808008 6.580450e-18 3.293650e-16 12 57055643 57055795 153 - 1.344 2.014 2.277
ENSG00000166881 E002 80.041798 0.0036630330 8.655701e-21 6.093632e-19 12 57055796 57055883 88 - 1.646 2.189 1.826
ENSG00000166881 E003 948.122213 0.0095808160 1.877401e-07 1.808542e-06 12 57055884 57057644 1761 - 2.823 3.094 0.902
ENSG00000166881 E004 839.107088 0.0001765449 2.151966e-01 3.446620e-01 12 57057645 57059589 1945 - 2.833 2.905 0.241
ENSG00000166881 E005 193.120836 0.0014081719 1.285008e-08 1.552656e-07 12 57059590 57059878 289 - 2.237 2.114 -0.409
ENSG00000166881 E006 166.874368 0.0035137131 6.904758e-06 4.762043e-05 12 57059879 57060059 181 - 2.173 2.052 -0.406
ENSG00000166881 E007 156.581684 0.0046999220 2.425398e-03 8.538064e-03 12 57060772 57060945 174 - 2.136 2.069 -0.225
ENSG00000166881 E008 3.462456 0.0086247884 1.471672e-02 3.985132e-02 12 57061597 57061665 69 - 0.440 0.883 1.918
ENSG00000166881 E009 187.426747 0.0002314247 4.051353e-07 3.648933e-06 12 57063119 57063344 226 - 2.215 2.145 -0.236
ENSG00000166881 E010 102.892072 0.0008437994 2.175494e-06 1.678235e-05 12 57064071 57064185 115 - 1.969 1.844 -0.420
ENSG00000166881 E011 90.036227 0.0003309788 2.327100e-05 1.421082e-04 12 57064646 57064739 94 - 1.908 1.802 -0.358
ENSG00000166881 E012 77.856148 0.0003119292 2.935210e-06 2.200937e-05 12 57069234 57069306 73 - 1.852 1.705 -0.495
ENSG00000166881 E013 111.400836 0.0002543008 3.967731e-10 6.330959e-09 12 57070674 57070819 146 - 2.011 1.832 -0.601
ENSG00000166881 E014 90.221201 0.0003056108 1.557710e-12 3.696649e-11 12 57070820 57070893 74 - 1.932 1.670 -0.885
ENSG00000166881 E015 101.969993 0.0002757911 5.866008e-13 1.493479e-11 12 57072788 57072880 93 - 1.982 1.738 -0.823
ENSG00000166881 E016 63.327862 0.0037018003 1.273779e-05 8.259628e-05 12 57072881 57072912 32 - 1.773 1.580 -0.656
ENSG00000166881 E017 78.176415 0.0006213975 5.522800e-06 3.893127e-05 12 57078619 57078791 173 - 1.854 1.711 -0.483
ENSG00000166881 E018 0.000000       12 57087951 57088063 113 -