ENSG00000166845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000300091 ENSG00000166845 HEK293_OSMI2_2hA HEK293_TMG_2hB C18orf54 protein_coding protein_coding 2.785255 0.823068 4.04798 0.09403278 0.2540779 2.284256 0.4958078 0.38539152 0.7742676 0.05259319 0.05947464 0.9880641 0.2626292 0.4910000 0.1911667 -0.2998333 0.0126091149 0.0005637077 FALSE TRUE
ENST00000620105 ENSG00000166845 HEK293_OSMI2_2hA HEK293_TMG_2hB C18orf54 protein_coding protein_coding 2.785255 0.823068 4.04798 0.09403278 0.2540779 2.284256 1.1077207 0.35077826 1.4701567 0.10319710 0.10494931 2.0365656 0.4319000 0.4089667 0.3676667 -0.0413000 0.8678901282 0.0005637077 FALSE TRUE
ENST00000648616 ENSG00000166845 HEK293_OSMI2_2hA HEK293_TMG_2hB C18orf54 protein_coding protein_coding 2.785255 0.823068 4.04798 0.09403278 0.2540779 2.284256 0.8847407 0.08689827 1.5968221 0.04118921 0.14280026 4.0515955 0.2557125 0.1000333 0.3940000 0.2939667 0.0005637077 0.0005637077 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000166845 E001 1.068433 0.0133389236 5.744340e-01 7.002409e-01 18 54357906 54357916 11 + 0.250 0.372 0.800
ENSG00000166845 E002 6.616091 0.0024104133 5.507859e-02 1.181359e-01 18 54357917 54357974 58 + 0.860 0.570 -1.199
ENSG00000166845 E003 12.126271 0.0016700629 2.163287e-02 5.491542e-02 18 54357975 54358075 101 + 1.082 0.809 -1.026
ENSG00000166845 E004 12.785549 0.0123412545 4.238357e-02 9.541932e-02 18 54358482 54358584 103 + 1.103 0.853 -0.931
ENSG00000166845 E005 17.701109 0.0098681780 2.103549e-03 7.544843e-03 18 54358585 54358773 189 + 1.247 0.892 -1.293
ENSG00000166845 E006 11.184597 0.0021699262 9.774507e-02 1.870578e-01 18 54358774 54358870 97 + 1.041 0.852 -0.706
ENSG00000166845 E007 26.461227 0.0007394152 6.878366e-03 2.090758e-02 18 54360527 54360855 329 + 1.395 1.184 -0.742
ENSG00000166845 E008 29.474811 0.0096901778 1.957066e-03 7.092634e-03 18 54361643 54361891 249 + 1.447 1.166 -0.985
ENSG00000166845 E009 7.808646 0.0531486457 2.464290e-01 3.817678e-01 18 54361892 54361948 57 + 0.905 0.706 -0.785
ENSG00000166845 E010 18.952880 0.0010711234 1.450815e-01 2.549486e-01 18 54361949 54362431 483 + 1.240 1.122 -0.421
ENSG00000166845 E011 25.323818 0.0022211331 2.015340e-02 5.180605e-02 18 54362771 54362921 151 + 1.370 1.184 -0.653
ENSG00000166845 E012 0.000000       18 54363904 54363981 78 +      
ENSG00000166845 E013 18.497560 0.0010547412 7.060309e-03 2.138205e-02 18 54365719 54365821 103 + 1.255 0.993 -0.944
ENSG00000166845 E014 23.298969 0.0092934919 5.613688e-03 1.758805e-02 18 54372466 54372597 132 + 1.350 1.075 -0.972
ENSG00000166845 E015 12.441924 0.0062181299 2.789374e-01 4.186182e-01 18 54374214 54374249 36 + 1.070 0.962 -0.400
ENSG00000166845 E016 13.791112 0.0012683028 1.969148e-01 3.223695e-01 18 54374250 54374284 35 + 1.114 0.993 -0.443
ENSG00000166845 E017 23.425726 0.0008230921 1.244447e-01 2.263149e-01 18 54378174 54378326 153 + 1.331 1.221 -0.387
ENSG00000166845 E018 124.518474 0.0003022287 9.314038e-01 9.607883e-01 18 54378327 54380883 2557 + 2.011 2.035 0.080
ENSG00000166845 E019 14.203013 0.0013465646 1.897926e-01 3.135000e-01 18 54380884 54380928 45 + 1.065 1.221 0.559
ENSG00000166845 E020 50.074536 0.0115818953 9.340677e-10 1.392808e-08 18 54380929 54381675 747 + 1.488 1.924 1.479
ENSG00000166845 E021 14.375543 0.0138179701 7.997537e-10 1.207643e-08 18 54381676 54381729 54 + 0.878 1.523 2.303
ENSG00000166845 E022 19.800623 0.0060299087 2.383085e-11 4.670201e-10 18 54381730 54382034 305 + 1.040 1.619 2.024
ENSG00000166845 E023 0.000000       18 54385117 54385218 102 +